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4925787 |
Monoclonal anti-idiotypic antibody, method for production thereof, and hybridoma producing said antibody
A monoclonal anti-idiotypic antibody specific to a human IgG 1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the...
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4921791 |
Method for measuring specific component using peroxidase enzyme reaction
A method for measuring a specific component, which comprises having a complex conjugate comprising a specific component to be measured and a labelled body having peroxidase as the label carried on...
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4916075 |
Differential homogeneous immunosensor device
There is provided a novel method of testing for the presence of an analyte in a fluid suspected of containing the same. In this method, in the presence of the analyte, a substance capable of...
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4912034 |
Immunoassay test device and method
An apparatus is provided for use in an immunoassay for the detection of a target analyte in a liquid sample, comprising a porous reactive filter, having an upper surface and a lower surface, to...
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4908305 |
Competitive elisa for determination of neutralizing IBDV antibody
A method for determining the level of infectious bursal disease virus IBDV neutralizing antibody in poultry comprising a labeled monoclonal antibody R63 having the IBDV neutralizing capability of...
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4891313 |
Method for determination of a component of a sample
This invention relates to apparatus useful in determining a component or components of a test sample, as well as methods using these apparatus. Of particular interest are apparatus and methods...
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4889798 |
Heterologous system for the detection of chemically labeled DNA and other biological materials providing a receptor or target moiety thereon
In accordance with the practices of this invention, there is provided a heterologous detection system and components useful in conjunction therewith and kits for carrying out the heterologous...
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4883579 |
Photoresponsive redox detection and discrimination
Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be...
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4880731 |
Process and reagent for the determination of a reaction partner of an immunological reaction
For the determination of a reaction partner of an immunological reaction according to the principle of immunoassay, the reaction partner to be determined is brought into contact with a marked...
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4874710 |
Assay and product in which binder and liposomes are supported on a solid support
In an assay, a conjugate of ligand and sac lysing agent is contacted with analyte and binder to produce bound and unbound portions of conjugate. The unbound portion of the conjugate contacts sacs,...
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4873313 |
Specific hybridoma cell line and monocolonal antibodies produced from such specific hybridoma cell line and method of using such monoclonal antibodies to detect carcinoembryonic antigens
A specific hybridoma cell line produces monoclonal antibodies which are effective in detecting carcinoembryonic antigens (CEA). The specific hydribome line and monoclonal antibodes are designated...
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4870007 |
Immobilized biotinylated receptor in test device, kit and method for determining a ligand
A device useful for the determination of a ligand in an aqueous liquid comprises a water-insoluble substrate. Immobilized in at least one location on that substrate is a biotinylated receptor for...
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4868106 |
Analytical element and method for determining a component in a test sample
Disclosed are an analytical element for determining a specific component A in a test sample, based on the specific reaction between said specific component A and a substance B capable of binding...
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4857457 |
Screening test for large intestinal cancer
The disaccharide β-D-Gal (1->>3)-D-GalNAc, which specifically binds with peanut agglutinin (PNA) or oxidized by galactose oxidase, has been discovered in the colorectal mucus of patients...
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4840893 |
Electrochemical assay for nucleic acids and nucleic acid probes
The present invention discloses an assay for nucleic acid which comprises the steps of; (a) providing a probe material comprising; (i) a sequence of nucleic acids complementary to a given...
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4824784 |
Chromogenic solution for immunoassay
A chromogenic solution for enzyme immunoassay. A stabilizing agent is added to chromogenic solutions containing chromogen of the hydrogen donor type. The stabilizing agent is an alkylhydroxylamine,...
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4806311 |
Multizone analytical element having labeled reagent concentration zone
A multizone test device for the determination of analyte from a liquid test medium upon contact with the liquid test medium and a labeled reagent comprising a chemical group having a detectable...
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4806467 |
Method for the detection of equine infectious anemia and other retrovirus infections using a competitive enzyme-linked immunoabsorbent assay and reagents useful in the same
The present invention relates to a method of detecting either antibody or antigen in the serum of horses infected with equine infectious anemia using a competitive enzyme-linked immunoabsorbent...
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4803155 |
Monoclonal antibodies to Sclerotinia homoeocarpa
This invention provides monoclonal antibodies which specifically bind to Sclerotinia homoeocarpa the causative agent of dollarspot disease in plants. Hybridoma producing the antibodies as well as...
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4798795 |
Biotinylating agents
Compounds having a dithiopyridyl moiety linked to a biotin moiety are useful as thiol specific biotinylating agents. The biotin label can be cleaved in a reducing environment to yield the native...
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4789630 |
Ionic compounds containing the cationic meriquinone of a benzidine
Useful for visualizing biological materials in a solid phase, on a gel, or in a liquid phase is a solid salt of the meriquinone of benzidine or a substituted benzidine. An immobilized or dissolved...
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4788138 |
Method to achieve a linear standard curve in a sandwich immunoassay
A method for obtaining an actual linear standard curve in a sandwich type of immunoassay where a first antibody bound to an insoluble support and a second unbound labelled antibody complex with the...
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4786594 |
Enzyme immunoassay
A method is disclosed for determining an analyte in a sample suspected of containing the analyte. The analyte is a member of a specific binding pair (sbp) consisting of ligand and complementary...
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4786589 |
Immunoassay utilizing formazan-prelabeled reactants
An immunoassay procedure utilizing a formazan-labeled primary antibody to detect the presence of an antigen is disclosed. The formazan-labeled antibody is dissolved in a test fluid suspected to...
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4782014 |
Assay and purification of amyloid components, applications, and kits therefor
The invention relates to a new method of immunological analysis for serum amyloid A protein (SAA) and serum amyloid P-component (SAP), kits therefor and a method of purification of SAA and SAP....
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4778751 |
Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
The method of measuring circulating antigens or antibodies by using a ligand labeled specific antigen or ligand labeled specific antibody chemically attached to a soluble matrix or backbone, a...
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4772572 |
Hybridomas and monoclonal antibodies to human IL-2
Certain hybridomas preparing monoclonal antibodies to human interleukin-2 (IL-2) which do not cross react with rator mouse IL-2 are disclosed. The secreted monoclonal antibody can be used in...
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4772548 |
Radioisotopicassay using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4772550 |
Heterogeneous specific binding assay employing an aggregatable binding reagent
A heterogeneous specific binding assay method for determining the amount of a suspected analyte in an aqueous test medium wherein a reaction mixture is formed by combining the test medium with...
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4746604 |
Specific binding assays utilizing a viable cell as a label
A method and composition for detecting analyte moieties by means of a signalling moiety capable of aggrandizement are disclosed. The signalling moiety can be attached to or not attached to the...
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4738920 |
Method for assaying a biocomponent using 4-methoxy-1-naphthol and hydrogen peroxide
The present invention provides a method for assaying a biocomponent on the basis of an amount of bound peroxidase by the steps of supporting a biocomponent or a target substance containing a...
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4729961 |
Process for the detection and assay by erythroadsorption
A process for the detection and assay of a biological substance by erythroadsorption by immobilizing a substance having a binding affinity for the biological substance to be assayed; incubating the...
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4727019 |
Method and apparatus for immunoassays
Disclosed herein is an apparatus and process for conducting ligand receptor assays. The apparatus comprises a first member which is a membrane or a filter to which is bound a receptor for the...
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4722890 |
Quantitative assay for human terminal complement cascade activation
The present invention discloses an enzyme-linked immunosorbent assay (ELISA) to quantitate fluid phase terminal complement activation. Upon activation to form C5b-9, terminal complement components...
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4716123 |
Solid phase biological diagnostic assay via visual observation as enhanced by Mie scattering
Methods and kits are set out having improved selectivity and improved sensitivity for use in field and home immunoassays. A specifically binding biomaterial is attached to a macroextensive surface...
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4713324 |
Inverted latency specific binding assay
A specific binding assay composition and method for determining a ligand in a sample are disclosed. The composition comprises (a) a binding partner for the ligand; (b) a detection system which has...
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4692405 |
Monoclonal antibodies to antigen on activated human B-cells and assay therefor, protein antigenic determinant therefor and method of making same
A monoclonal antibody recognizing an antigenic determinant on activated human B-cells, the antigenic determinant being characteized in that it is a protein distinct from B-LAST-1 and BB-1, the...
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4687732 |
Visualization polymers and their application to diagnostic medicine
A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or...
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4686181 |
Specific binding assay employing anti-G6PDH as label
A specific binding assay method and reagent system based on the use of an inhibitory anti-enzyme, e.g., antibody or fragment thereof, as the label component. Such method and reagent system have...
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4684609 |
Method and substance for the enhanced labelling of cellular material
An enhanced labelling complex for localizing markers on a prepared tissue section is disclosed. The complex includes both avidin components and biotinylated macromolecular components at a ratio...
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4677057 |
Diagnostic assay for the presence of apolipoproteins associated with plasma high density lipoproteins
Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-II, are described as are their methods of use and articles of manufacture...
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4677061 |
T-cell lymphocyte subset monitoring of immunologic disease
Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific surface...
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4670384 |
Diagnostic reagent for swine trichinosis
A hybrid cell formed by the fusion of a mouse spleen cell with a mouse myeloma cell secretes an IgM class antibody. The antibody is useful as a preparative reagent in the isolation of three...
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4656252 |
Amidobiotin compounds useful in a avidin-biotin multiple layering process
Amidobiotin extender compounds useful, for example, in avidin-biotin multiple-layering process, which compounds include caproylamidobiotin-NHS ester, caproylamidobiotin-horse radish peroxidase,...
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4656025 |
Quantitative screening assay of tumor globulin from gastric juice
A quantitative screening protocol for the assay of tumor globulin which is separated from gastric juice of human patients at risk for gastric cancer comprising a purification procedure by column...
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4649105 |
Method of measuring biological ligand
A method of measuring a biological ligand comprises allowing to coexist a biologically active composition comprising an immobilization phase of a particular antibody or a particular ligand and an...
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4629689 |
Binding assay with amplified read-out and gas-phase detection
At the conclusion of a selective binding assay (e.g., immunological or nucleic acid), an enzyme is present in modulated concentration and/or activity to moderate a chemical reaction such as the...
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4629688 |
Homogeneous specific binding assay method
A test composition, device, and method for their use in a homogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, as a labeling substance in the...
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4617261 |
Process for labeling nucleic acids and hybridization probes
Nucleic acids may be labeled by intercalating the alkylating intercalation moiety of a labeling reagent into a partially double-stranded nucleic acid to form a complex and activating the complex to...
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4582793 |
Anti-RNA polymerase I antibody test for the diagnosis of rheumatological diseases
A method is described for the differential diagnosis of rheumatological diseases. Sera from patients with SLE; MCTD, and RA are screened for antibodies directed against RNA polymerase II using a...
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