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5185128 |
Test kit containing labeled receptor and wash solution for determination of an immunological ligand
A test kit useful for the determination of an immunological ligand includes a labeled receptor for that ligand, a specific wash solution and a test device. The wash solution is buffered to a pH of...
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5183735 |
Method and diagnostic test kit for detection of anti-dsDNA antibodies
A diagnostic element for detecting the presence of anti-dsDNA antibodies in a sample. The diagnostic element includes a support (e.g., a microcell), a coating of mBSA on the support, dsDNA antigens...
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5180663 |
Immunochemical assays for human amylase isoenzymes and related monoclonal antibodies, hydridoma cell lines and production thereof
Immunochemical assays for human amylase isoenzymes are disclosed. These assays utilize monoclonal antibodies which are produced from hybridoma cell lines and are specific for human salivary amylase...
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5175113 |
Modified β.sub.2 -microglobulin
Substantially pure modified β 2 -microglobulin (mβ 2 m) of the formula I ##STR1## wherein R 1 is 24-amino acid residue, with the sequence...
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5168044 |
Immunodiagnostic assays for use in the detection and determination of mastitis
Immunodiagnostic assays for the detection and determination of mastitis and sub-chemical mastitis comprise capturing neutrophils or fragments or soluble products thereof in a milk sample on an...
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5162238 |
Test carrier for analysis of a liquid sample
The present invention provides a test carrier for the analysis of a sample liquid with a test layer which contains a ligand fixed to to carrier particles, which ligand reacts with a component of...
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5158880 |
Process for preparing solid perfluorocarbon polymer supports having attached perfluorocarbon-substituted ligand or binder
A process for preparing solid perfluorocarbon polymer supports permitting uniform and secure attachment of perfluorocarbon-substituted ligands or binders to carriers is provided utilizing...
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5156950 |
Quantitation of human pulmonary surfactant and reagent kit to be used therefor
A method of quantitation of human pulmonary surfactant characterized by determining the quantity of human pulmonary surfactant in the test sample according to the immunological method by use of the...
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5155023 |
Enzyme immunoassay procedure for amphipathic analytes
Immunoreagents for the release, non-specific capture and detection of lipopolysaccharides (LPS) that may be diagnostic for microorganisms causative for, among other things, Chlamydia trachomatis or...
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5154887 |
Phenalenimine fluorescent dyes and their use in analytical compositions, elements and methods
Certain phenalenimine fluorescent compounds represented by the structure ##STR1## wherein R' and R" are independently hydrogen, alkyl, cycloalkyl, aryl or a heterocycle, or R' comprises the carbon...
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5149629 |
Coulometric assay system
The invention relates to a novel assay for the determination of entities having biological activity and to a device for carrying out such determinations. The assay is a very sensitive one and...
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5141876 |
Method and composition for the determination of kidney damages
The invention refers to a method as well as a composition for the quantitative determination of kidney damages by the application of polyclonal and monoclonal antibodies against villin and/or...
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5141850 |
Porous strip form assay device method
An immunoassay method comprising applying an aqueous solution containing the analyte antigen to one end of a multi-zoned test strip device such that the solution moves along the strip by capillary...
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5124249 |
Method for evaluating protection to bee venom
Venom immunotherapy is a highly effective treatment for bee sting sensitive individuals. Treated individuals and those naturally exposed to repeated bee stings, such as beekeepers have been shown...
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5122453 |
Method for discriminating surface stained lymphocytes
A flow cytometry method for reproducibly detecting and counting a lymphocyte population of interest in a leukocyte suspension or whole blood sample in which the red cells are subsequently lysed....
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5118609 |
Carrier fleece for use as a reagent carrier from which reagents can be dissolved in immunological analysis
A carrier fleece is prepared for use as reagent carrier from which reagents can be dissolved in as assay such as immunological analysis. The carrier fleece contains from 5 to 60% by weight of...
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5118610 |
Techniques for detecting insect contamination of foodstuffs
The present invention involves approaches to the detection of insect contamination of foodstuffs such as grain, for example. These approaches involve the detection of biological substances...
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5108900 |
Monoclonal antibodies to synthetic pyrethroids and method for detecting the same
Methods are described for making specific monoclonal antibodies which may be used in a sensitive immunoassay for detection of synthetic pyrethroids in foods and environmental samples. Appropriate...
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5108889 |
Assay for determining analyte using mercury release followed by detection via interaction with aluminum
An assay employing a tracer comprising a ligand having a mercury label wherein mercury label is released from at least one of a bound or free tracer phase and interacts with a metal. Analyte is...
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5108896 |
Simultaneous immunoassay of two analytes using dual enzyme labelled antibodies
The present invention relates to dual analyte enzyme immunoassays for assaying two antigens in a single liquid sample wherein the two immunoreactions are carried out simultaneously and wherein...
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5100645 |
Method of diagnosis of amyloidosis
In accordance with the present invention, there is now provided a method for the diagnosis of amyloidosis, which comprises subjecting a protein sample such as serum, cerebrospinal fluid or brain...
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5093232 |
Nucleic acid probes
Modified nucleotides are provided which have the structure ##STR1## wherein R 1 is a reactive group derivatizable with a detectable label, R 2 is an optional linking moiety including an amide,...
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5087562 |
Humoral hypercalcemic factor antagonists with modification at position 13 . . .
The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide hormone analogues is exemplified by human...
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5087561 |
Humoral hypercalcemic factor antagonists modified at position 13 by biotin
The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide hormone analogues is exemplified by human...
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5085982 |
Method of detecting specific substances by selective growth of living cells
The invented method utilizes a signal amplification system comprising living cells which are specifically provided with the ability to survive, reproduce and be detected in the event that a target...
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5070013 |
Immunochemical assay for human granulocyte-macrophage colony stimulating factor
Monoclonal antibodies and compositions thereof are provided for detecting, measuring, and immunopurifying human GM-CSF.
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5068198 |
Liquid single reagent for assays involving confining gels
Assay methods and compositions are provided for determining an analyte in a sample suspected of containing the analyte. The composition comprises in a novel single liquid reagent at least one...
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5066580 |
Xanthene dyes that emit to the red of fluorescein
Novel xanthene dyes are disclosed which excite in the range of 450-650 nm and which will emit to the red of fluoroscein. These dyes may be coupled to tagging agents, such as monoclonal antibodies,...
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5051356 |
Specific binding composition comprising a low pI protein or carbohydrate and a diagnostic test kit and method of use
A specific binding composition comprises a specific binding species and one or more water-soluble proteins or carbohydrates, substantially none of which has a pI greater than about 5. This...
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5045535 |
Method, apparatus and a composition for a polysaccharide-containing matrix having covalently bound haptens
The present invention provides a process for the production of a polysaccharide matrix to which haptens are covalently bound, wherein polysaccharide-containing material is rendered alkaline, dried...
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5024935 |
Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor
A dye-providing composition comprises a water-soluble or -dispersible polymer, such as a vinylpyrrolidone polymer, and an imidazole leuco dye capable of providing a dye in the presence of hydrogen...
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5019498 |
Method of assaying high molecular hyaluronic acid and kit of reagents for such assay
A high molecular hyaluronic acid which is an important factor in the diagnosis of inflammations such as rheumatism or diseases such as cancer is assayed as a complex of sandwich structure in which...
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5017474 |
Wash solution, test kit and method for the determination of an immunological ligand
An aqueous wash solution is buffered to a pH of from about 5 to about 9 and contains at least about 0.01 weight percent of a compound comprising a dodecyl sulfate anion and an alkali metal or...
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5015588 |
Method for the detection of factor XIII in plasma
An assay method for the detection of Factor XIII in plasma is disclosed in which a primary amine derivative of biotin such as preferably 5-(biotinamido) pentylamine is incubated with a glutamine...
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5011770 |
DNA detection method
Picogram amounts of DNA can be detected in a sample by the use of high-affinity, single-stranded DNA binding proteins. The assay is applicable not only to pure DNA samples but also to samples...
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5006473 |
Electrophoresis method using vesicles
The electrophoresis method of the present invention employs a media which contains uniformly dispersed liposomes of phospholipid, or combinations of phospholipid and neutral lipid, which contain...
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5004699 |
Method to detect fungi and yeasts
A method for detecting organisms such as fungi and yeast in a sample attached to a solid phase, by detecting the presence of chitin in using lectin or anti-chitin antibodies.
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5003050 |
Diazoluminomelanin and a method for preparing same
A water-soluble luminescent compound having repeating units of the formula: ##STR1## The product, which is a polymer having repeating units comprising diazo-linked luminol and hydroxyindole, is...
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5001049 |
Method for determination of HIV specific antibodies
The invention relates to a method for determining HIV (human immunodeficiency virus) specific antibodies. A sample is incubated with a solid phase, to which streptavidin is bound in a way to make...
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4988627 |
Test device with dried reagent drops on inclined wall
An immunoassay test device is disclosed with dried reagent drops applied to a sloping side wall of a reaction wall. A method of applying them as liquid drops is also described, wherein the slope of...
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4988629 |
Lactoferrin-containing incubation medium for solid-phase immunometric methods and its use
Incubation media intended for solid-phase immunometric assays and containing lactoferrin are described. Compared with the media used hitherto, these incubation media have the advantage that they...
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4966839 |
Process for the determination of an immunologically bindable analyte
The present invention provides a process for the determination of a bindable analyte according to the principle of heterogeneous immunoassay by incubation of a sample solution which contains the...
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4966838 |
Process for the immunological quantitative determination of T3 and/or T4 thyroid hormones, using thyroglobulin
The invention relates to a process for the immunological quantitative determination of the T 3 and/or T 4 thyroid hormones. In a process for the immunological quantitative determination of T 4...
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4960692 |
Assay employing binding pair members on particles and on a filter or membrane
An assay method and kit in which particles bearing a first reagent binding pair member (e.g., anti-digoxin antibody) react with a sample such that analyte binding pair member (e.g., digoxin) binds...
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4959303 |
Assay for antigens by binding immune complexes to solid supports free of protein and non-ionic binders
Methods are disclosed for detecting an antigen in a biological sample. The methods involve providing in combination a solid support, which is substantially free of specific binding proteins, and a...
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4948726 |
Enzyme immunoassay based on membrane separation of antigen-antibody complexes
An enzyme immunoassay based on membrane separation of antigen-antibody complexes wherein human or animal body fluid specimens containing an antigen are mixed with an enzyme-conjugated antibody...
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4948723 |
Method of diagnosis and severity-assessment of pancreatic disease
Pancreatic disease can be diagnosed by assaying a patient's body fluid, e.g. serum or urine, for the activation peptides of pancreatic zymogens specifically cleaved by proteolysis during...
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4945045 |
Electrochemical methods of assay
A ligand in a sample can be assayed using electrochemical apparatus containing a working electrode and components comprising: (a) the sample, (b) a specific binding partner to the ligand, or...
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4943636 |
Certain pyridyl-di-sulfide-alkylenecarbonxylate-ortho-nitro-phenylsulfonic acid esters useful for coupling biological materials
Coupling of biological materials is disclosed via 4-hydroxy-3-nitrobenzene sulfonic acid sodium salt (HNSA) esters. The novel activated esters are structured so as to react at one end with an amine...
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4935339 |
Delayed solid phase immunologic assay
A method for the determination of a substance present in a sample, which comprises: (a) contacting a sample containing a substance with: (i) a first immunological binding partner to the...
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