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7374950 |
Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7361480 |
Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies...
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7361462 |
Method for efficiently determining a DNA strand break
The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors...
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7358062 |
Method for diagnosing atrophic gastritis
The press device for a paper web, such as a calender, contains a flexible moving element ( 1 a ) forming an endless structure, said element forming the shell ( 1 ) of a roll, the press device...
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7354735 |
Nucleic acid encoding fluorescent protein constructs and methods for detecting apoptosis
Isolated nucleic acids encoding a fluorescent protein construct that detect apoptosis are disclosed. The isolated nucleic acids contain a donor-acceptor pair of green fluorescent proteins and a...
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7351524 |
Diagnostics and therapeutics for macular degeneration-related disorders
The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7344703 |
Mycobacterial sulfation pathway proteins and methods of use thereof
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7332290 |
Dectection of AMACR cancer markers in urine
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression...
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7314727 |
Methods to facilitate diagnosis of normal pressure hydrocephalus
The present invention relates to methods for differentiating demential diseases comprising measuring the concentration of human lipocalin-type prostaglandin D synthase in a sample of a body fluid...
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7314709 |
Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence...
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7312090 |
Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical...
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7309578 |
Therapeutic treatment of chronic obstructive pulmonary disease
The present invention provides a method of treating or preventing a chronic obstructive pulmonary disease in a subject, comprising administering to said subject an amount of an agent affective to...
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7303885 |
Screening method for candidate drugs
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
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7300761 |
Methods and device for detecting prostate specific antigen (PSA)
An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed...
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7297312 |
Simultaneous multianalyte electrochemical assay based on spatial resolution
A simultaneous multianalyte electrochemical assay includes a cell which has a surface and the surface includes analyte binding sites i.e., antibodies or antigens on a solid phase at distinct...
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7291474 |
Hydrolytic substrates for an analyte-dependent enzyme activation system
Disclosed are compounds of the general formulas:
wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is...
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7279290 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7241582 |
Diagnostic test kits
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus...
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7238483 |
Method for detecting catalytic activity
This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the...
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7235672 |
Probe, assay and kits for detecting 11β-hydroxysteroid dehydrogenase and modulators thereof
A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises:
wherein DM is a detectable marker; and L is a straight or branched chain moiety...
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7232661 |
Diagnostic agents for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing the same
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method,...
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7226751 |
Detecting the presence of pyruvate kinase isoenzyme in feces
In order to selectively, qualitatively or/and quantitatively detect the pyruvate kinase isoenzyme of the tumor M2-PK type (tumor M2-PK) which serves as a tumor marker in human and animal feces to...
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7225080 |
Diagnosis method of inflammatory, fibrotic or cancerous disease using biochemical markers
The present invention is drawn to a new diagnosis method for detecting the extend of a inflammatory, fibrotic or cancerous disease in a patient, in particular liver fibrosis, in particular in a...
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7223552 |
Myeloperoxidase, a risk indicator for cardiovascular disease
Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of...
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7217534 |
Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic...
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7217527 |
Assay for phosphodiesterase function
The present invention provides filter-based assays for measuring binding of compounds to phosphodiesterases (PDEs). The assay permits stoichiometric binding of compounds to PDEs, thereby providing...
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7217523 |
Nucleoside phosphoramidates and nucleoside phosphoramidases
The invention provides isolated nucleic acid sequences encoding polypeptides having nucleoside phosphoramidase activity, and methods of screening for nucleoside phosphoramidate compounds that are...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7183071 |
Anthrax lethal factor is a MAPK kinase protease
The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease...
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7169572 |
Assays for determining anticoagulant cofactor activity
Methods are disclosed for determining, in a sample derived from a human, the functional activity of a component of the human blood coagulation system, which activity can be correlated to conversion...
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7169564 |
FKBP51/52 and CyP40-mediated mammalian hair growth
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.
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7157237 |
Antibodies for enzymes of the ω-oxidation pathway and methods relating thereto
The present invention provides antigenic peptides useful for the production of antibodies which selectively bind to an enzyme involved in the ω-oxidation of fatty acids and alkanes to...
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7157223 |
Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility
The activity of intracellular chemical reactions of molecules is measured by the use of fluorescently labeled substrate molecules that undergo a change in electrophoretic mobility upon chemical...
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7153660 |
Non-invasive enzyme screen for tissue remodelling-associated conditions
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are...
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7148028 |
Methods and means relating to atherosclerosis
The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for...
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7144705 |
Diagnostic assay for stroke
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or...
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7141385 |
Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors
An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in...
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7129096 |
Sensor for use in testing biological, biochemical, chemical or environmental samples
Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same.
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7125728 |
Determination of pregnancy status in cattle and sheep
A method and kit for determining whether an animal is not pregnant, or is pregnant following a breeding. The level of expression of a pregnancy induced protein is determined in an animal for which...
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7122331 |
Isoprenoid biosynthesis
The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More...
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7122321 |
High throughput method for functionally classifying proteins identified using a genomics approach
The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of...
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7115382 |
Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex
Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for...
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7115229 |
Apparatus and method for monitoring molecular species within a medium
Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing....
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7112414 |
Masp-2, a complement-fixing enzyme, and uses for it
The present invention relates to substantially pure mannan-binding lectin associated serine protease-2 (MASP-2) polypeptides and fragments thereof as well as nucleic acids encoding such...
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7112413 |
Heteroaryl substituted benzothiazole dioxetanes
Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the...
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7108992 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
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7105310 |
Detection of biomolecules by sensitizer-linked substrates
Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic...
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