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7803567 |
Methods and compositions for detecting trichomonas in a sample contacted with fixative
The present invention provides methods and compositions for detecting a Trichomonas antigen in a fixed sample and for diagnosing Trichomonas infection by detecting a Trichomonas antigen in a fixed...
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7455985 |
Detection and quantification of intracellular pathogens
The present invention provides methods and compositions for detecting bacteria of the Chlamydiaceae family in a biological sample. Methods include, for example, contacting a biological sample with...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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7018807 |
Method and medium for detecting vancomycin-resistant enterococcus
A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium...
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7005270 |
Compositions and methods for detecting Treponema pallidum
Methods for the specific and highly sensitive detection of Treponema pallidum infection comprising the use of specific antigenic proteins and peptides unique to Treponema pallidum are provided. In...
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6955908 |
Organism associated with nongonococcal urethritis
The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument...
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6858439 |
Compositions and methods for separation of moieties on chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable,...
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6815173 |
Method for detecting syphilis using synthetic antigents
An antigen composition and method for the detection of antibodies to Treponema pallidum and the diagnosis of syphilis are described. The antigen composition contains synthetic cardiolipin and...
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6706490 |
Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen
A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the...
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6699678 |
Chlamydia trachomatis specific peptides and their use in diagnostic assays
Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis (C. trachomatis) immunodominant major outer membrane protein...
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6676949 |
Two-step immunization procedure against Chlamydia infection
A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration...
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6565856 |
Compounds and methods for treatment and diagnosis of chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia...
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6562586 |
In vitro model for HIV and other viral diseases
An in vitro model system for viral infection is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherin the supported tissue block...
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6479248 |
Process and agent for detecting antibodies against Treponema pallidum
A method and agent for antibodies against Treponema pallidum are provided. The method involves gene-amplifying and cloning a selection of recombinant antigens. The selection of recombinant antigens...
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6344335 |
Liposome immunoassay
A liposome or microsphere containing guaiac or other reagent is used in an immunoassay to detect an antigen or antibody. The guaiac or other reagent reacts with hemoglobin or other blood...
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6300140 |
Rapid test employing an adhesive slide
A slide having a portion thereof provided with transparent adhesive which adheres to a test sample. The slide and adhesive may be transparent. Specific types of infection and particularly fungal...
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6277965 |
CysS
The invention provides cysS polypeptides and DNA (RNA) encoding cysS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing cysS...
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6258532 |
Methods for in vitro susceptibility testing of chlamydia
Methods for determining the susceptibility of intracellular pathogens, particularly Chlamydia, to single or combination of test agents are described. The methods can be used for in vitro or in vivo...
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6207647 |
RatA
The invention provides ratA polypeptides and DNA (RNA) encoding ratA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratA...
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6165478 |
DNA encoding Chlamydia pneumoniae antigenic polypeptide
Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding said...
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6159703 |
Assays
Enhanced extraction and assay of solubilized lipopolysaccharide antigens from bacteria such as Chlamydia by the use of a buffer containing an anionic polysaccharide, especially heparin, and surface...
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6146839 |
Chlamydia pneumoniae antigens, method for production of the antigens, method and reagents for measurement of anti-Chlamydia pneumoniae antibodies using the antigens
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6096519 |
Chlamydia trachomatis serotype D proteins
A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or...
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6030799 |
Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthetic major outer membrane protein polypeptides as substitute antigens
Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia...
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5972350 |
Feline vaccines containing Chlamydia psittaci and method for making the same
The present invention relates to feline vaccines comprising inactivated a non reactive Chlamydia psittaci for prevention and treatment of chlamydia diseases in cats.
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5902722 |
Method of detecting organisms in a sample
The presence or absence of an organism in a sample is detected by isolating the organism from the sample by a suitable affinity matrix, releasing the organism from the affinity matrix, rupturing...
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5879881 |
Solid phase system for use in ligand-receptor assays
A solid phase system for use in ligand-receptor assays, particularly immunoassays using monoclonal antibodies, is disclosed. The solid phase system comprises a porous matrix in which microspheres,...
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5869272 |
Methods for detection of gram negative bacteria
Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an...
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5869234 |
Method of identifying compounds which modulate herpesvirus infection
The present invention relates to a method of identifying a compound which modulates (enhances, inhibits, reduces) herpesvirus infection of a vertebrate cell comprising the steps of combining a...
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5861263 |
Preparation of preserved entamoeba histolytica antigens without enzymatic inhibitors and their use in immunological methods
The method of the invention relates to the preservation of a complex antigenic system of Entamoeba histolytica molecules, without using enzymatic inhibitors and using these preserved Entamoeba...
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5858648 |
Assays using reference microparticles
Disclosed is an assay for determining the presence of at least one analyte in a sample, which involves the steps of: (a) mixing the sample and predetermined amounts of first test microparticles...
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5840508 |
Compositions and methods for removal of detergents
Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for...
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5773234 |
Method and device for chlamydia detection
A lateral flow assay device for detecting the presence of Chlamydia antigen in patient's samples comprises a flow matrix including a labelling zone and a capture zone. Labelling complex comprising...
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5731162 |
Method and analytical device for simultaneous immunoassay
The present invention concerns a method and an analytical device for the simultaneous detection of at least two organisms selected from the group consisting of Chlamydia trachomatis (CT), Neisseria...
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5716793 |
Method for diagnosing a patient for chlamydia
A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.
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5578456 |
Anti-treponema pallidum antibody immunoassay
A new method for assaying anti-Treponema pallidum antibody with improved sensitivity is provided. Anti-Tp antibody in serum is assayed by enzyme immunoanalysis utilizing the antigen-antibody...
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5532122 |
Quantitation of gamma and x-ray emitting isotopes
For isotopes decaying by capture of an inner shell electron by the nucleus, coincident emission of X-ray and gamma photons may occur. The X-ray results from the drop of an outer shell electron to...
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5516638 |
Immunoassays for the detection of antibodies to Chlamydia trachomatisi in the urine.
The present invention provides methods for detecting the presence of antibodies to a microorganism (e.g., Chlamydia trachomatis) associated with a sexually transmitted disease in a biological...
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5484706 |
Immunoassay for analytes in samples using alkylating agents
An improved immunoassay method and kit have been developed that include a sample pretreatment method and kit employing an alkylating agent that modifies antibodies in the sample to render the...
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5482830 |
Devices and methods for detection of an analyte based upon light interference
Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon,...
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5418136 |
Devices for detection of an analyte based upon light interference
Optical assay device having an active receptive surface supported on a pedestal and held within a first container; the first container comprising first absorbent material located at the base of the...
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5415994 |
Lateral flow medical diagnostic assay device with sample extraction means
The present invention provides devices, methods, and kits for treatment and detection of analytes requiring pretreatment in samples. One-step treatment and detection is possible utilizing the...
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5415995 |
Diagnostic peptides of human papilloma virus
A series of seventeen synthetic peptides which are capable of raising antibodies specific for certain desired human papilloma virus (HPV) are useful in diagnosis and therapy of conditions...
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5393658 |
Immunoassay method for the rapid identification of detergent treated antigens
An assay is provided in which a target ligand is detected in a biological specimen. The method involves treating the target ligand with detergent and then binding the treated ligand to a particle...
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5391478 |
Assay device and immunoassay
This invention relates to an improved assay device and assay for detecting or quantitating the presence or absence of a substance in a sample. The device has multiple layers comprising a permeable...
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5354654 |
Lyophilized ligand-receptor complexes for assays and sensors
A dry reagent prepared by lyophilizing a labelled ligand-immobilized receptor complex or a labelled receptor-immobilized ligand complex is, on rehydration, useful for detecting analytes in samples...
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5318892 |
Method for assaying antibody against Chlamydia trachomatis and diagnostic preparation for chlamydia trachomatis infection
There is provided an assay method for a Chlamydia trachomatis antibody with almost no cross reaction with a C. pneumoniae antibody or a C. psittaci antibody associated using an antigen containing...
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5246851 |
Monoclonal antibody specific for a 14kd protein obtained from N gonorroeae
A monoclonal antibody, specific for N. gonorrhoeae, specifically binds to a protein which is obtained from N. gonorrhoeae, which has a molecular weight of about 14 kD as determined by SDS-PAGE and...
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5234817 |
Wash solution containing a cationic surfactant and its use in chlamydial and gonococcal determinations
A wash solution having a pH of from about 7 to about 12 comprises at least about 0.1 weight percent of one or more cationic surfactants. This wash solution is useful in assays for chlamydial or...
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