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7629137 |
Methods and apparatus for detecting bacteria using an acoustic device
Methods for detecting bacteria are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the bacteria, is combined with the sample to form a...
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7582415 |
Rapid detection of replicating cells
The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial...
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7514089 |
Genetically modified tumor-targeted bacteria with reduced virulence
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention...
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7449340 |
Method for the early diagnosis of cancer
The present invention relates to a method for the early diagnosis of cancer in a subject, which is based on determination of the relative fraction of microorganisms derived from the feces of the...
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7442517 |
Method for the detection of Salmonella enterica serovar Enteritidis
Described herein is the identification of a novel Salmonella enterica serovar Enteritidis locus that serves as a marker for DNA-based identification of this bacterium. In addition, three primer...
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7270969 |
Methods of constructing and screening diverse expression libraries
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic...
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7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7208286 |
Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia
Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably...
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6958219 |
Method for detecting a gram-negative bacterial autoinducer molecule
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a...
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6905691 |
Vaccines containing attenuated bacteria
The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations...
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6881549 |
Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (—C(═O)—COOH) or a ketal or hemiketal group...
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6866847 |
Method of delivering a protein to poultry
A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that...
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6858439 |
Compositions and methods for separation of moieties on chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable,...
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6818409 |
Isolation and purification of Clostridium botulinum toxins
A method for separating and purifying HA-positive progenitor toxin(s) (LL and/or L toxins) and HA-negative progenitor toxin (M toxin) from a Clostridium botulinum strain is provided. The method...
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6815172 |
Methods and compositions for opsonophagocytic assays
Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides...
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6713073 |
Method of vaccination of newly hatched poultry
A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed.
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6689569 |
Saliva test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies
A method for determining a cause for digestive and immune disorders is disclosed. The method determines the levels of antibodies against normal intestinal microflora and food antigens. It then...
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6630355 |
Magnetic focusing immunosensor for the detection of pathogens
A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and...
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6566508 |
Fluorogenic compounds and uses therefor
Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when...
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6509166 |
Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction
The presence or absence of a target microbial analyte in a substance, such as a biological or environmental substance, is assayed by inoculating a sterile growth media with a sample of the...
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6495334 |
Recombinant Sef14 fimbrial protein from Salmonella
A truncated SE fimbria antigen useful as an antigen for immunoassay diagnosis of Salmonella enteritidis (SE) infection or evidence of infection.
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6391653 |
Acoustic standing-wave enhancement of a fiber-optic salmonella biosensor
A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium . A biosensor test chamber serves as an ultrasonic...
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6379918 |
Composition, formulae, devices and methods for control of specificity and inclusivity of microorganisms containing closely related antigen epitopes
Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or...
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6348318 |
Methods for concentrating ligands using magnetic particles
This invention provides methods, compositions and kits for concentrating target ligands, including microorganisms, from samples, including biological samples. The methods involve the use of...
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6203996 |
Rapid detection of bacteria liquid cultures
A means for the rapid detection of bacteria from a liquid culture or slurry is described. A membrane mounted on a solid support is immersed in a liquid culture for a time sufficient to allow...
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6159689 |
Methods of capture and assay procedures
Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species,...
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6004766 |
Method for detecting low levels of microorganisms
A method is provided for the detection of low levels of a microorganism in a sample in the presence of competing microflora, comprising the steps of: (a) exposing the sample to a solid support to...
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5989841 |
Polypeptides and nucleic acids derived from Salmonella typhi and detection of Salmonella using thereof
Nucleic sequences from the genome of Salmonella Typhi include all or part of the genetic information required for the in vitro infection of cultured HeLa cells by Salmonella bacteria. Polypeptides...
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5965458 |
Test strip, its production and use
A test strip for a rapid immunoassay containing specific immunochemical reagent zones (7, 8, 9) is described. The test strip (10) has a backing sheet (1) and attached thereto a receiving end pad...
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5935799 |
Biological assay for microbial contamination
A semi-quantitative method for determining the concentration of viable coliforms or E. coli in a liquid is provided. The sample to be tested is mixed with an indicator reagent which includes a...
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5902722 |
Method of detecting organisms in a sample
The presence or absence of an organism in a sample is detected by isolating the organism from the sample by a suitable affinity matrix, releasing the organism from the affinity matrix, rupturing...
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5871944 |
Salmonellae preferential media
A new Salmonella preferential media uses lactose and cellobiose to suppress formation of black colonies by non-Salmonella, to permit easy inspection of the media to determine the presence or...
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5840509 |
Protease and related nucleic acid compounds
The present invention provides for a novel ICE related protease and nucleic acids coding same. The present invention also provides a method to isolate an ICE related protease and related DNA...
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5817472 |
Detection of motile fungal zoospores in a sample
A method for detecting motile organisms, particularly zoospores of Phytophthora cinnamomi in a sample comprises contacting the sample with a solid support in a medium in which the organisms are...
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5807694 |
Detection of salmonella enteritidis and other pathogenic microorganisms and monoclonal antibody useful therefor
A method of testing for the presence of a pathogenic microorganism, notably Salmonella enteritidis, in a foodstuff, e.g. the contents of an egg, or other materials. In a particularly preferred form...
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5695946 |
Assay method for detecting presence of bacteria
An assay method is provided to easily and quickly detect the presence of organisms capable of being cultured, such as bacteria, characterized by antibody capture of the organism of interest by use...
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5663057 |
Process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence
Process for rapid, ultrasensitive and automatic counting of fluorescent biological cells such as microorganims, carried by a solid support such as a filter. The process includes: scanning a solid...
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5658747 |
Compositions and methods for control of reactivity between diagnostic reagents and microorganisms
Compositions, devices and methods for the detection of target microorganisms, such as by a visual immunoprecipitation assay, where the detection requires the migration of the target microorganisms...
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5556745 |
Method for the detection and quantitative determination of antigen in a test sample containing immune complexes of antigen bound to antibodies and to rheumatoid factors
The invention is a simple and rapid method for immune complex dissociation and destruction of rheumatoid factors. It permits the quantitative measurement of the total, i.e., free and immune...
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5552294 |
Rapid detection of virulence-associated factors
A method for detecting at least one virulence-associated factor (VAF), e.g., a bacterial toxin, in a sample is described. The sample suspected of containing the VAF-producing bacteria is contacted...
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5510241 |
Method of testing for the presence of Salmonella serotypes expressing Salmonella enteritidis fimbrial antigen (SEFA) and reagents therefore
A method of testing for the presence of Salmonella serotypes S. enteritidis and S. dublin is provided. Novel monoclonal antibodies are used to detect the presence of an epitope specific for these...
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5484706 |
Immunoassay for analytes in samples using alkylating agents
An improved immunoassay method and kit have been developed that include a sample pretreatment method and kit employing an alkylating agent that modifies antibodies in the sample to render the...
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5434056 |
Method of bacteriological analysis, and medium for the detection of bacteria of the Salmonella genus
The invention relates to a method of bacteriological analysis for the selective detection of Salmonella and a medium for its implementation. The method is based on the specific capacity of...
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5356778 |
Method for detection of gram-negative bacterial liposaccharides in biological fluids
The invention relates to a method of detecting gram-negative bacterial endotoxin using antibody capture combined with amoebocyte lysate chromogenic detection. The method is highly sensitive and...
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5354654 |
Lyophilized ligand-receptor complexes for assays and sensors
A dry reagent prepared by lyophilizing a labelled ligand-immobilized receptor complex or a labelled receptor-immobilized ligand complex is, on rehydration, useful for detecting analytes in samples...
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5208161 |
Filter units
An assay filter unit where the filter of the unit is sealed into the body of the unit to prevent any passage of material to be assayed round the edge of the filter but is removable by breaking out...
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4920063 |
Process for detection of selected motile organisms
Methods and associated devices for detecting the presence of a particular motile organism within a sample are disclosed. The sample may be derived from dry milk, raw meat, poultry or a clinical...
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4683196 |
Method and materials for the identification of lipopolysaccharide producing microorganisms
The subject invention provides a means for the immunological detection of an entire class of microorganisms in clinical samples. The detection is accomplished by reaction of the clinical sample...
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4677055 |
Immunological detection of bacterial pathogens with antibody-containing magnetic gel
A process for the immunobacteriological detection of pathogenic germs possessing specific antigenic determinants, and a kit for carrying out the process, with the aid of a magnetic gel to which are...
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