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5750357 |
Method of rapid analyte detection
A detectable synthetic copolymer useful to detect the presence of a microorganism in a test sample is provided. The copolymer comprises repeating monomeric units, which incorporate a population of...
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5747272 |
Detection of shiga-like toxins of enterohemoragic Escherichia coli
A rapid, sensitive, non-radioactive diagnostic kit for the direct detection of both Shiga-like toxin, type I, and Shiga-like toxin, type II, produced by enterohemorrhagic Escherichia Coli in food...
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5744314 |
Periplasmic membrane-bound system for detecting protein-protein interactions
The present invention relates to: (1) a fusion protein having a dimerizing domain with or without a ligand-binding region and toxR DNA-binding and hydrophobic transmembrane regions; (2) host...
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5736341 |
Methods and test kits for specific and sensitive diagnosing of periodontal diseases
Methods and test kits are described which provide a reliable, sensitive and selective assessment of periodontal disease activity, peri-implantitis or HIV(+)-infection/AIDS-disease related...
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5736347 |
Nucleic acids of Rochalimaea henselae and methods and compositions for diagnosing Rochalimaea henselae and Rochalimaea quintana infection
A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an antigenic fragment thereof in the...
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5731162 |
Method and analytical device for simultaneous immunoassay
The present invention concerns a method and an analytical device for the simultaneous detection of at least two organisms selected from the group consisting of Chlamydia trachomatis (CT), Neisseria...
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5731163 |
Lyophilized bioluminescent bacterial reagent for the detection of toxicants
A reagent, useful in the detection of environmental insults comprising bacterial cells containing a stress promoter operably linked to a lux gene complex has been prepared by lyophilizing the cells...
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5731161 |
Botulinum toxin antibody detection assay
An assay for the identification of neutralizing botulinum antibodies in sera is provided which includes the steps of separating non-sodium dodecyl sulfate, non-trypsinized complex botulinum toxin...
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5721109 |
Method for diagnosing infection caused by acid-fast bacterium
A reagent for the detection of an antibody against an acid-fast bacterial antigen comprising at least one compound selected from the group comprising mycolic acids, mycolic acid salts, mycolic acid...
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5719033 |
Thin film transistor bio/chemical sensor
A chemical sensor includes a thin film transistor with a gate positioned on one side. An insulating layer is positioned on the opposite side and an indicator film is positioned on the insulating...
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5716829 |
Diagnostic test for Pseudomonas aeruginosa infections
Methods and reagents are provided for a novel immunodiagnostic test for the presence of P. aeruginosa in a biological sample. Monoclonal antibodies are employed which bind to an outer membrane...
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5716793 |
Method for diagnosing a patient for chlamydia
A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.
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5712102 |
Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes
The lipopolysaccharide of bacteria associated with chronic inflammatory diseases is unable to induce expression of leukocyte adhesion molecules, or selectins, on endothelial cells, and is also...
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5707819 |
Diagnosis of Mycobacterium bovis infection
A method for the diagnosis of Mycobacterium bovis infection in a susceptible animal, comprises detection in said animal of antibodies against the MPB-70 protein of M.bovis and/or the detection of a...
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5707816 |
Immunological cross reactivity between Candida and human tissue or food antigens
A method of determining immunological cross reactivity between Candida and human tissue or food antigens. Tissue antigen preparations or food extracts are analyzed by electrophoresis. Cross...
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5702911 |
Diagnostic test composition
The present invention relates to an improved test composition for the diagnosis of gastric ulcers, duodenal ulcers, gastritis, gastric lymphoma and gastric carcinoma by the detection of the...
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5696000 |
Adhesion receptors for pathogenic or opportunistic microorganisms
Disclosed herein are receptors for pathogenic or opportunistic microorganisms, methods of obtaining such reeptors, and methods of using such receptors for diagnostic or pharmaceutical purposes. The...
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5695946 |
Assay method for detecting presence of bacteria
An assay method is provided to easily and quickly detect the presence of organisms capable of being cultured, such as bacteria, characterized by antibody capture of the organism of interest by use...
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5691151 |
Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca
The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The...
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5688659 |
Streptolysin O peptide antigens and methods for the determination of streptolysin antibodies
SLO peptide antigens are described. These peptide antigens are suitable for the determination of SLO antibodies, as immunogens for the production of antibodies against SLO and as vaccines for the...
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5677137 |
Method to identify immunocompromised patients at high risk for cryptococcosis
The present invention provides a method of identifying immunocompromised individuals who are at high risk for development of cryptococcosis, comprising the step of measuring the levels of IgG...
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5674696 |
Apparatus for the determination of a trace amount of an analyte substance or organism
There is disclosed an apparatus for the determination of a trace amount of an analyte substance or organism. A substrate solution is brought into contact with a small diameter tube which has...
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5665559 |
Production of monoclonal antibodies to bacteroides gingivalis by hybridoma BGII, VF9/2D
A monoclonal antibody is disclosed which is reactive to Bacteroides gingivalis and produced by the hybridoma deposited under ATCC HB 9968. The invention also discloses diagnostic reagents and...
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5663057 |
Process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence
Process for rapid, ultrasensitive and automatic counting of fluorescent biological cells such as microorganims, carried by a solid support such as a filter. The process includes: scanning a solid...
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5658747 |
Compositions and methods for control of reactivity between diagnostic reagents and microorganisms
Compositions, devices and methods for the detection of target microorganisms, such as by a visual immunoprecipitation assay, where the detection requires the migration of the target microorganisms...
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5648227 |
Method of detecting microorganisms
Method for detecting the presence or absence of a viable microorganism in a sample which has been subjected to a sterilization process, whereby the sample is contacted with an antibody which...
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5646001 |
Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
A method for separation of a mixture of biological entities into at least three distinct, subpopulations. Different antibodies are provided, with each antibody bound to a solid support in a unique...
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5641638 |
Monoclonal antibodies against Mycoplasma pneumoniae, hybridomas producing these, methods for the preparation thereof, and the use thereof
The invention relates to monoclonal antibodies and fragments thereof which are specific for Mycoplasma pneumoniae P2 protein and have a cross-reactivity of 1% or less with five other species of the...
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5628996 |
Method for inhibiting the viability of Pseudomonas aeruginosa with cross-reactive and cross-protective monoclonal antibodies
Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical...
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5629214 |
Methods for forming an optical device for detecting the presence or amount of an analyte
A method for forming an optical device for detecting the presence or amount of an analyte of interest comprising a substrate which supports an optically active layer, an attachment layer provided...
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5627045 |
Multi-test format with gel-forming matrix for characterization of microorganisms
The present invention is directed to methods and compositions for the characterization of various microorganisms. In particular, the present invention is suited for the characterization of commonly...
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5622831 |
Methods and devices for manipulation of magnetically collected material
Methods and devices are disclosed which are useful for collecting magnetic materials in either internally or externally generated magnetic gradient fields, followed by resuspension into solution...
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5620845 |
Immunoassay diagnostic kit
An immunoassay process is provided for the detection of a target antigen in a fluid sample where an admixture of the target antigen and a labeled capture reagent against the target antigen is...
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5620848 |
Methods for detecting mutant p53
A panel of probes detects and distinguishes between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells Each set of mutations gives...
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5620862 |
Methods for diagnosing early Lyme disease
The invention relates to DNA encoding Borrelia burgdorferi sensu stricto outer surface protein C. Purified and recombinant forms of a 23 kDa protein from a Connecticut isolate of B. burgdorferi are...
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5618533 |
Flagellin-based polypeptides for the diagnosis of lyme disease
Diagnostic means and methods for Lyme disease comprising B. burgdorferi flagellin polypeptides and antibodies. Compositions and methods comprising neuroborreliosis-associated antigens useful for...
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5610023 |
Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
A method is provided for the purification of Clostridium difficile Toxin A comprising reacting impure Toxin A with immobilized mono-specific polyclonal antibodies. The polyclonal antibodies are...
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5605806 |
Reagent for assaying endotoxin
The present invention provides a reagent for assaying an endotoxin which comprises limulus amoebocyte lysate and an antibody to (1 ➝ 3)-β-D-glucan sensitive factor or a reagent which comprises a...
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5604108 |
Test for determining the dose response of a conjugated vaccine
The dosage response of humans to conjugate vaccines comprising a bacterial polysaccharide and a strongly-immunogenic carrier protein is determined in animals by coadministering to the animal...
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5591596 |
Process for preparing a purified treponemal antigen and use thereof
A process for preparing a purified syphilis antigen which comprises adsorbing an extract originated from Treponemda pallidum on a hydroxyapatite gel, followed by elution, while an aqueous medium is...
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5582997 |
Lysine/leucine polypeptides, mixture sets and libraries thereof
Polypeptides, sets and libraries of sets of polypeptides that are related in sequence to the polypeptide of SEQ ID NO:1 are disclosed that have antimicrobial, hemolytic and hydrolytically catalytic...
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5578455 |
Method for determining endotoxin and apparatus therefor
There is disclosed a method for determining an endotoxin by reacting the endotoxin adsorbed on an adsorbent having specific endotoxin adsorbability with an endotoxin detecting reagent, including...
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5567598 |
Microbial monitoring device
This invention presents methods for detection and evaluation of metabolic activity of microorganisms based upon their ability to consume dissolved oxygen. The methods utilize a fluorescence...
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5567594 |
Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms
A library of isolated and purified antigens specific for a microorganism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing and...
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5563040 |
Method and apparatus for immunological diagnosis of fungal decay in wood
A method and apparatus for detecting incipient fungal decay in wood is described. Anti-xylanase monoclonal antibody is immobilized in a defined capture zone to a polyester assay substrate....
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5556745 |
Method for the detection and quantitative determination of antigen in a test sample containing immune complexes of antigen bound to antibodies and to rheumatoid factors
The invention is a simple and rapid method for immune complex dissociation and destruction of rheumatoid factors. It permits the quantitative measurement of the total, i.e., free and immune...
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5556757 |
Peptides representing epitopic sites for bacterial and viral meningitis causing agents and their CNS carrier and uses thereof
Peptides comprising a Meningitis Related Homologous Antigenic Sequence (MRHAS) are provided. The MRHAS is found in meningitis-causing organisms and chemokines involved in cell chemotaxis. The...
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5552294 |
Rapid detection of virulence-associated factors
A method for detecting at least one virulence-associated factor (VAF), e.g., a bacterial toxin, in a sample is described. The sample suspected of containing the VAF-producing bacteria is contacted...
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5552272 |
Detection of an analyte by fluorescence using a thin film optical device
Device for detecting the presence or amount of an analyte of interest, comprising a reflective solid, optical support and a label capable of generating fluorescent signal upon excitation with a...
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5541072 |
Method for magnetic separation featuring magnetic particles in a multi-phase system
Methods and devices are provided for separation of magnetic particles and/or magnetic-associated substances from non-magnetic associated substances and media. The methods are specifically...
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