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5939279 |
Inhibition of bacterial binding by high-mannose oligosaccharides
The present invention describes a method for the treatment of gram-negative bacterial infections using high-mannose containing oligosaccharides. Specifically the use of Man 9 (GlcNAc) 2 ...
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5932428 |
Method for preparing a sample in a scan capillary for immunofluorescent interrogation
An assay and sample mixture for the enumeration of fluorescently stained target components of a whole blood sample by an imaging instrument. The sample preparation method ensures that the amount of...
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5928957 |
Determination of analyte concentration based on a micellar recognition system and structured layers therefor
Starting from two non-miscible phases, i.e., a lipophilic and a hydrophilic phase, a surface-active substance and a recognition component, a micellar recognition system is built in a suitable...
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5928865 |
Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected...
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5914240 |
Method and test kits for detection of bacteriophage
A method for detection, identification and/or quantification of bacteriophage of bacterial host specificity for bacterial genus, species or serotype, based upon the occurrence of release of cell...
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5902722 |
Method of detecting organisms in a sample
The presence or absence of an organism in a sample is detected by isolating the organism from the sample by a suitable affinity matrix, releasing the organism from the affinity matrix, rupturing...
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5891704 |
Method to produce high levels of methioninase
The present invention discloses the cloning of a methioninase-encoding nucleic acid molecule from Pseudomonas putida and the construction of high-level expression modules containing the...
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5888757 |
Cell wall assay
Disclosed are methods that can be used to (1) measure the level of polysaccharide in a sample; (2) measure the ability of a compound to degrade a polysaccharide; (3) measure the ability of a...
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5888754 |
Device and method of use for detection of bacterial lipopolysaccharides
This invention relates to a device comprising a hydrophobic solid support coated with a chemical that can capture bacterial lipopolysaccharides (LPS). This invention also relates to the use of such...
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5882872 |
Use of an IL-6 assay for predicting the development of post-trauma complications
Diagnostic methods are described for using the concentration of a cytokine present in serum or other biological fluids in order to predict the predisposition of an individual to post-trauma...
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5876943 |
Helicobacter TagA gene fusion protein
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is...
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5871943 |
Immunoassay comprising a truncated pneumococcal surface protein A (PspA)
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble...
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5871937 |
Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute...
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5869272 |
Methods for detection of gram negative bacteria
Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an...
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5866321 |
Analytical method and device for precise analysis with a simple sensor
An analyte and a reactant 3 that reacts with the analyte either directly or indirectly are allowed to react with each other on the analytical areas A of a substrate 1 and signals originating from...
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5866344 |
Antibody selection methods using cell surface expressed libraries
The invention relates to novel competitive immunoassays that are useful in detecting and quantitatively measuring analytes down to the nanomolar range. The invention also includes methods of...
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5863802 |
Method and test kit detecting antigens and/or antibodies
A suspension of inert particles is prepared in an aqueous solution, to which an antibody or an antigen and a carrier-bound antigen or antibody, respectively, are needed in any desired order. After...
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5858648 |
Assays using reference microparticles
Disclosed is an assay for determining the presence of at least one analyte in a sample, which involves the steps of: (a) mixing the sample and predetermined amounts of first test microparticles...
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5858697 |
Method for rapid diagnostic of urinary tract infections
Method for the rapid diagnostic of an infection of the urinary tract (UTI), by a specific examination of urine. The method of analyzing a urine specimen, for the rapid and simultaneous counting of...
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5856108 |
Biosynthesis of diazomelanin and diazoluminomelanin and methods thereof
There is provided a method for producing diazoluminomelanin (DALM) which comprises culturing in a medium containing nitrate, 3-amino-L-tyrosine (3-AT) and luminol under suitable metabolic...
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H001775 |
Rapid assay for detection of endotoxins
The presently claimed invention is an apparatus and method for the detection of endotoxin via a competitive assay.
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5846731 |
Peralkylated oligopeptide mixtures
Linear peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of...
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5846751 |
Test kits and methods for detecting H. pylori
A sensitive and specific antigen preparation for the detection of Helicobacter pylori in biological samples is disclosed. The preparation uses a range of antigens derived from size exclusion...
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5840508 |
Compositions and methods for removal of detergents
Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for...
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5834197 |
Methods of capturing species from liquids and assay procedures
A species such as a microorganism, e.g. Legionella, Giardia or Cryptosporidium, is captured by first attracting plastic coated magneticbeads or other magnetically attractable particles to a solid...
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5827749 |
Ligand assay method
Methods for determining the presence of a ligand in a sample suspected to contain the ligand are provided, along with apparatus suitable for performing the methods. The methods depend upon a color...
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5817472 |
Detection of motile fungal zoospores in a sample
A method for detecting motile organisms, particularly zoospores of Phytophthora cinnamomi in a sample comprises contacting the sample with a solid support in a medium in which the organisms are...
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5814470 |
Melittin-related polypeptides, mixture sets and libraries thereof
Sets and libraries of sets of polypeptides that are related in sequence to melittin are disclosed that have antimicrobial, hemolytic and hydrolytically catalytic activities, as are processes for...
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5814468 |
Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution
This invention relates generally to using fluorescent markers (labelled antibodies) and flow cytometry to enumerate the average number of receptors (antigen) on formed bodies (cells) in whole...
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5807694 |
Detection of salmonella enteritidis and other pathogenic microorganisms and monoclonal antibody useful therefor
A method of testing for the presence of a pathogenic microorganism, notably Salmonella enteritidis, in a foodstuff, e.g. the contents of an egg, or other materials. In a particularly preferred form...
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5807690 |
Method of screening physiological samples for elevated levels of heat shock proteins
METHOD OF SCREENING PHYSIOLOGICAL SAMPLES for elevated levels of heat shock proteins due to chronic exposure to sublethal levels of stressors, and kits for carrying out the method, are disclosed....
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5804370 |
Early diagnosis of sepsis utilizing antigen-antibody interactions amplified by whole blood chemiluminescence
The invention relates to a method for determining the extent of sepsis and/or an infection in a human or animal patient by detecting the amount of an antigen indicative of such infection. The...
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5804393 |
Antibodies directed to the binding proteins of Bacillus thuringiensis and their use
The present invention relates to an antibody which reacts specifically with the binding proteins for Bacillus thuringiensis δ-endotoxins and their derivatives. The invention further relates to an...
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5798214 |
Capture asays
A method is provided for determining the presence and/or amount of a microorganism and/or its intracellular material present in a sample performed by: (a) exposing the sample to a specific binding...
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5798276 |
Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
The invention describes reactive dyes having an alkyl spacer attached via a sulfonamide bond to a sulforhodamine 101 fluorophore, and a variety of useful conjugates prepared therefrom. The...
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5792604 |
Method of identifying MHC-class I restricted antigens endogenously processed by cellular secretory pathway
A method of identifying antigens which are capable of being endogenously processed by a cellular secretory pathway comprising: introducing an antigen into a donor cell lacking in MHC class I...
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5789173 |
Methods for rapid antimicrobial susceptibility testing
The present invention discloses a method for rapid antimicrobial susceptibility testing to screen antibiotics in a few hours instead of days by conventional methods. This method can also be used to...
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5786220 |
Assays and devices for distinguishing between normal and abnormal pregnancy
Methods and devices for distinguishing between normal and abnormal pregnancies are provided. The methods rely on determining the concentration of progesterone or progesterone metabolite in a...
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5786151 |
Microencapsulated labelling technique
Labelling techniques for specific binding agents are provided wherein the label used comprises a microcapsule containing a nucleotide, preferably in solid form and preferably in crystalline form....
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5786162 |
Fused genes and their use for determining the presence of metals or of xenobiotic compounds
The invention relates to a fused gene containing: the promoter sequence of (a) gene(s) encoding the resistance to one or several metal(s) or encoding the catabolism of one or several xenobiotic...
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5783399 |
Chemiluminescent assay methods and devices for detecting target analytes
A method which utilize chemiluminescence for analyte detection and the detection of bacteria on surfaces. The method uses a device comprising a sampling portion made of a first adsorbent material,...
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5780246 |
Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of stressors
Method of detecting chronic exposure of an organism to a stressor, and for evaluating biological damage due to chronic exposure to sublethal levels of stressors and kits for carrying out the method...
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5776712 |
Methods and materials for the detection of Staphylococcus aureus
The present application discloses a novel method for the detection of Staphylococcus aureus and methicillin-resistant strains of Staphylococcus aureus. Further disclosed is an approximately 230 kDa...
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5776721 |
In vitro model for study of the pharmacodynamics of intracellular killing of bacteria and viruses
Adherent cell lines are grown on cover slips. The cover slips are placed in a culture media containing fluctuating concentrations of drugs for the purpose of testing simulated drug dosage regimens...
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5773234 |
Method and device for chlamydia detection
A lateral flow assay device for detecting the presence of Chlamydia antigen in patient's samples comprises a flow matrix including a labelling zone and a capture zone. Labelling complex comprising...
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5773233 |
Monoclonal antibody specific to nitrifying bacteria and method for detection thereof
The present invention relates to a monoclonal antibody showing a high specificity to Nitrosomonas europaea or Nitrobacter agilis, and a monoclonal antibody-sensitized latex for detecting...
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5770361 |
Protein conferring an inducible resistance to glycopeptides, particularly in gram-positive bacteria
The invention relates to a protein VanB involved, in Gram-positive bacteria, in resistance to glycopeptides, particularly to vancomycine, said resistance being of the type inducible by the...
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5766607 |
Method of culturing M. bovis in low available iron media and isolation of outer membrane proteins
An improved vaccine against infectious bovine keratoconjunctivitis is provided which is derived from an appropriate Moraxella bovis strain cultured in a relatively low available iron medium which...
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5759786 |
Synergistic microbicidal combinations containing 4,5-dichloro-2-octyl-3-isothiazolone and certain commercial biocides
Synergistic microbicidal compositions comprising a first component consisting of 4,5-dichloro-2-octyl-3-isothiazolone and a second component selected from one or more of the compositions...
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5750344 |
Method for selection of biologically active peptide sequences
An improved method for determining binding compounds from a mixture of similar compounds, particularly a phage peptide library, is provided. The method comprises contacting a mixture of candidate...
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