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6846667 |
Virulence genes and proteins, and their use
The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The...
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6844199 |
Direct detection of bacteria-antibody complexes via UV resonance Raman spectroscopy
A system for the detection of bacteria based on bacteria-antibody complexes. Bacteria attached to antibody are detected with resonance Raman spectroscopy. The bacteria are detected directly in a...
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6841159 |
Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria
An assay method and kit is disclosed for detecting the presence of at least one predesignated, target antibody to a mycobacterium in a sample selected from one or more patient bodily fluids. The...
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6841345 |
Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic derivatives of lipid A
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral...
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6841393 |
Selective removal of contaminants from a surface using colored particles and articles having magnets
A system and method for removing contaminants from a surface. The system is designed to use very small particles having means thereon which are capable of selectively binding to a contaminant or...
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6835552 |
Impedance measurements for detecting pathogens attached to antibodies
The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated...
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6830895 |
Method and kit for typing feline blood
The present invention relates to a kit for determining feline blood type, wherein the kit includes a mixture comprised of a first monoclonal antibody and a second monoclonal antibody, wherein both...
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6825001 |
DNA molecules and protein displaying improved triazine compound degrading ability
This invention relates to the identification of homologs of atrazine chlorohydrolase and the use of these homologs to degrade s-triazine-containing compounds. In particular, this invention includes...
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6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
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6821739 |
Methods of diagnosing and treating Crohn's disease using Pseudomonas antigens
The present invention provides a method of identifying an agent useful in treating Crohn's disease. This method is practiced by culturing P. fluorescens under conditions that support growth;...
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6815174 |
Thioredoxin-glutamate decarboxylase 65 fusion protein
The present invention relates to a novel protein, a recombinant fusion hybrid, thioredoxin-human glutamate decarboxylase 65 and to a method of using such fusion protein in assaying anti-human...
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6815172 |
Methods and compositions for opsonophagocytic assays
Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6806253 |
Immunodulatory complex and use thereof in helicobacter diseases
A therapeutical vaccine complex having activity specific for Helicobacter bacteria as well as non-specific immunomodulation activity for regulating the natural defenses of the body. The drug is...
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6770487 |
Bar code readable diagnostic strip test
Diagnostic test devices, including diagnostic strip tests, are provided in which identifying information and the test result are machine-readable. Also provided are methods for obtaining...
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6767713 |
Pasteurella neuraminidase diagnostic methods and immunoassay kit
Provided are Pasteurella multocida coding sequences, recombinant DNA molecules, recombinant host cells and methods for making recombinant neuraminidase. Also provided by the present disclosure...
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6759205 |
Construction of a strain of Bacillus subtilis 168 that displays the sublancin lantibiotic on the surface of the cell
A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and...
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6753183 |
Immunologically active proteins from Borrelia burgdorferi
Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B....
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6740485 |
Anti-bacterial methods and materials
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and provision of...
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6733983 |
Method for identifying a mycobacterium species
The invention relates to a method for identifying a Mycobacterium species comprising the steps of: a) contacting at least one immuno-cross reactive antigen component of a mycobacterial species...
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6730230 |
Use of high density microparticles for removal of pathogens
Methods of using high-density microparticles to bind and remove pathogens from biological fluids are disclosed. Pathogens include prions, viruses, bacteria and protozoa.
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6727076 |
Comparative phenotype analysis
The present invention relates to growing and testing microorganisms in a multitest format which utilizes a gel forming matrix for the rapid screening of clinical and environmental cultures. The...
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6727073 |
Method for detecting enteric disease
A method for determining and diagnosing inflammatory enteric disease using an immunochromatographic test device having a multiplicity of test zones. The method tests for the presence of at least...
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6720160 |
Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals
The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals...
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6716574 |
Osp-C derived peptide fragments
A diagnostic method is disclosed which utilizes short C-terminal fragments of Borrelia burgdorferi sensu lato derived protein OspC. The 4 amino-terminal acids Pro-Lys-Pro (SEQ ID NO: 22) are...
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6713250 |
Identification of human allergens and T-lymphocyte antigens in vitro
The invention provides a method for screening a test compound for the ability of the test compound to induce a response from human naive T-cells. The method comprises admixing human naive T cells,...
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6706490 |
Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen
A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the...
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6699679 |
Methods for rapid identification of bacillus cereus
The present invention provides a method for rapid identification of Bacillus Cereus comprising utilizing an antibody specific to a certain surface antigen of B. cereus , and the kit for...
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6699678 |
Chlamydia trachomatis specific peptides and their use in diagnostic assays
Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis ( C. trachomatis ) immunodominant major outer membrane protein...
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6699674 |
Expression and refolding of truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi . The invention is useful for detecting prior...
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6696262 |
Method for screening the risk of gastric cancer
Method for screening the risk for gastric cancer using, in combination, the determination of serum pepsinogen I, gastrin-17 and the supporting determination of Helicobacter pylori antibodies from...
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6696264 |
Method and apparatus for detection of multiple biological materials with a heterogeneous antibody mixture
The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for...
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6696243 |
Method for the analysis of soluble analytes
A method of analyzing the concentration of soluble analyte in a sample involves performing a competition assay using a predetermined amount of formed bodies to which are attached at least one...
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6692973 |
Surface binding of an immunoglobulin to a flexible polymer using a water soluble varnish matrix
The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for...
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6689572 |
E. coli agglutination assay
A method for detecting Escherichia coli in a sample by providing a sample suspected of containing Escherichia coli ; contacting the sample with beads coated with a mixture of antibodies or...
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6686173 |
Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a multiwell testing device
The present invention relates to growing and testing microorganisms in a multitest format which utilizes a gel forming matrix for the rapid screening of clinical and environmental cultures. The...
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6667159 |
Optical fiber biosensor array comprising cell populations confined to microcavities
A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and...
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6667158 |
Antibodies against type a botulinum neurotoxin
Antibodies for binding epitopes of BoNT/A and hybridomas which produce such antibodies are described. The antibodies of the present invention can be used in a method for detecting BoNT/A in a...
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6660274 |
Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi...
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6653135 |
Dynamic protein signature assay
An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a...
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6649360 |
Test strip for detecting gastric problems based on the presence of urease
A testing apparatus for detecting urease in a gastric material taken from a human or lower animal subject is disclosed, the apparatus comprising a dry indicating composition responsive to urease, a...
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6649368 |
Composition and method for treating tissue samples
Compositions and methods are described for enhancing the immunohistochemical staining of tissue samples. Compositions include a single solution, which includes at least one surfactant, adapted to...
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6638730 |
Composition for qualitative screening of phosphate solubilizing microorganisms and a qualitative method for screening microorganisms
The present invention relates to a composition useful for qualitative screening of phosphate solubilizing microorganism, and also relates to a synergistic composition for qualitative screening of...
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6638482 |
Reconfigurable detection and analysis apparatus and method
Methods and apparatus for use of a stacked, reconfigurable system is provided. The stacked, reconfigurable system includes an inlet for receipt of a sample, a first chamber defined by a bottom...
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6635259 |
Escherichia coli secreted protein B
Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli , and produce a strong serum antibody response...
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6632614 |
Method for detecting anti-Streptococcus pyogenes DNase B antibody in a test sample
The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli , allowing efficient and rapid production of the...
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6630582 |
Treatment and prevention of helicobacter infection
An antigenic preparation for use in the treatment or prevention of Helicobacter infection in a mammalian host, comprises the catalase enzyme of Helicobacter bacteria, particularly the catalase...
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6630315 |
Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound
This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as “MHC class II” for short) which occurs on the surfaces of...
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6627728 |
Compounds from moraxella catarrhalis
The invention provides BASB010 polypeptides and polynucleotides encoding BASB010 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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