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4868109 |
Immunological antibody complex, its preparation and its use
The invention relates to an immunological complex of two antibodies of a first animal species, e.g. mouse antibodies, which have been conjugated to form a cyclic tetramer with two monoclonal...
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4863852 |
Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors
A method is provided for detecting the presence of C. difficile toxin A. Stool or other appropriate specimen is contacted with a reagent containing an available non-reducing...
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4855227 |
Rapid detection of mycoplasmas
A clinical diagnostic method capable of rapidly detecting the presence of Mycoplasma pneumoniae in infected humans is taught. The method allows a proper course of therapy to be chosen within one...
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4851329 |
Immunoassay employing optical pulse particle size analysis
This invention provides a means for determining the concentration of any of a wide range of antibody or antigen molecules with a high degree of specificity, accuracy and sensitivity. Antigen or...
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4851333 |
Method and composition for the detection and diagnosis of Legionella pneumophila
Method and compositions including monoclonal antibodies to a serogroup-common antigen are provided for the detection and diagnosis of Legionella pneumophila. The monoclonal antibodies recognize a...
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4833093 |
Method of silanization of surfaces
The present invention relates to a method of silanizing surfaces for use in detecting organic molecules and biomolecules by means of surface-sensitive detection methods. The molecules to be...
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4831126 |
Antigenic polysaccharide specific to Brucella abortus and Yersinia enterocolitica serotype 0:9
The antigenic O-chain polysaccharides from Brucella abortus and Yersinia enterocolitica serotype 0:9 have similar structure, i.e. 1-2 linked 4,6-dideoxy-4-formamido-α-D-mannopyranosyl units. The...
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4822732 |
Method of concentrating and detecting biomolecules and cells
A method of detecting biological substances having affinity properties by passing the substance to be detected in a flow over a solid surface to which surface a second substance, to which the...
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4820634 |
Immunoassay method and immunoreactive cell reagent
Immunoassay which can be performed within a short period of time and a reagent composition for such immunoassay. The reagent composition contains complement and cells which contain quantitatively...
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4818677 |
Membrane assay using focused sample application
Methods and kits are described for performing immunoassays. The kit includes a reaction cell having a microporous membrane and an absorbent capable of drawing liquid sample through the membrane. An...
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4812409 |
Hydrolyzable fluorescent substrates and analytical determinations using same
Hydrolyzable substrates comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum absorptions above about 530 nm and maximum...
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4803160 |
Use of polymeric mordants to increase the intensity of rigid fluorescent dyes
Polymeric mordants are used with certain rigid fluorescent dyes or precursors thereof to increase fluorescence intensity. Compositions and analytical elements containing the mordants and dyes or...
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4795702 |
Diagnostic method for gonorrhea by assay of IgA1 fragments
Method for assay of fragments produced by the reaction between the enzyme immunoglobulin A protease and its substrate immunoglobulin A, sub-class 1. IgA1, IgAP and also bacteria which secrete IgAP...
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4792521 |
Non-enzymatic immunohistochemical staining system and reagents
A non-enzymatic method of immunohistochemical staining uses a bound electron transfer agent to achieve amplification of antibody binding to specific antigens of interest in a histology or cytology...
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4789742 |
Isomaleimide and isophthalimide derivatives of chromophors
Novel Isomaleimido and isophthalimido derivatives of chromophoric compounds are provided which are useful in analytic techniques for the detection and measurement of biological compounds such as...
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4786592 |
Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
A bacterial lectin isolatable from Neisseria gonorrhoeae is disclosed. This lectin binds to gonococcal carbohydrates such as gangliotetraosylceramide, has a relative molecular weight of about...
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4784943 |
Ice nucleation immunoassay
A novel method for carrying out immunoassays is described. The method involves use of a biological ice nucleating agent as a label. In particular, the method involves use of ice nucleating...
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4780409 |
Thermally induced phase separation immunoassay
An immunoassay in which a thermally induced phase separation is used to effect the separation of specifically bound reactants from free reactants is disclosed. A first reactant is conjugated to a...
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4780407 |
Monoclonal antibodies to legionella, a process for their preparation and their use in the determination of legionella pneumophila
A process to produce hybrid cell lines, which produce monoclonal antibodies to Legionella pneumophila. Cell lines are produced by fusion of immunized mouse splenocytes to these bacteria with non...
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4777136 |
Monoclonal antibody reactive with Pseudomonas Aeruginosa
A hybridoma cell line identified by ATCC #HB8909, capable of producing monoclonal antibodies reactive with an antigenic determinant of lipopolysaccharide which is common to all strains of...
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4777130 |
Isolation of mycobacterial a 60 antigen for diagnostic purposes
A 60-like antigens isolated in a one-step reaction from the bacterial cytoplasma of Mycobacteria are useful for the production of diagnostic tests.
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4772548 |
Radioisotopicassay using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4761382 |
Immunological procedure for detecting or quantifying substances
This invention relates to a method of detecting, analyzing, quantifying, or locating a substance of biological interest by an immunoassay in which a first component of an immune reaction in the...
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4760019 |
Antigenic preparation and diagnostic method for identification of nocardia infections
A novel antigenic preparation and unique diagnostic methodology for the detection of human Nocardiosis is provided which is rapid, sensitive, and reproducibly accurate in providing empirical...
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4759927 |
Vaccine against Potomac horse fever and method of preparation therefore
A vaccine against Potomac Horse Fever comprises a deactivated E. risticii as the active agent. The agent may be obtained through inoculation of a cell culture, followed through deactivation by...
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4757001 |
Method of measuring biological ligand by utilizing amylase
The present invention relates to the method of measuring a biological ligand (1) in a sample containing an amylase (1) derived from a higher animal. This method is characterized by employing a...
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4752571 |
Method for determining certain bacterial polypeptides and antibodies directed against them
Method and means in/for the immunoassay determination of (I) a bacterial polypeptide capable of binding to the Fc protion of an immunoglobulin and/or (II) the high affinity antibody to said...
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4749647 |
Polymerization-induced separation assay using recognition pairs
Methods and compounds are disclosed for determining the presence, amount of, or association between substances of interest in samples suspected of containing same. The methods are based on the...
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4746604 |
Specific binding assays utilizing a viable cell as a label
A method and composition for detecting analyte moieties by means of a signalling moiety capable of aggrandizement are disclosed. The signalling moiety can be attached to or not attached to the...
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4744982 |
Human monoclonal antibody reactive with polyribosylribitol phosphate
A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the...
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4741999 |
Monoclonal antibodies useful in the identification of microorganisms causing periodontal disease
Actinobacillus actinomycetemcomitans has frequently been implicated in juvenile periodontitis. The present monoclonal antibodies are specific to Actinobacillus actinomycetemcomitans. The present...
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4737453 |
Sandwich immunoassay utilizing a separation specific binding substance
Immunoassay system for determining the amount of a polyvalent ligand in a liquid test sample, and based on: (a) an insoluble phase to which is bound a separation specific binding substance which...
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4722891 |
Methods and compositions for detection of Legionnaires' disease
Recombinant E. coli clones which cell surface-express Legionella pneumophila antigens, a method for utilizing these clones for the detection of Legionella antibodies in a clinical sample, and a...
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4711841 |
Method for determining one or more antigens in a sample
A method for determining one or more antigens in a sample by immunological reaction between the antigen and antibodies directed specifically against the antigen in the presence of a liquid, said...
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4693970 |
Immunoassay using complement
A method for immunoassay of an analyte in a fluid includes contacting the analyte with an antianalyte to give a bound fraction. The bound fraction activates the first component of complement...
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4693968 |
Agent for quantitative determination of microorganisms
An agent for quantitative determination of microorganisms, which comprises (a) an antibody prepared from a strain of the same species as the species of microorganisms to be determined, (b) an...
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4692404 |
Method of measuring biological ligand by the use of enzymes
A method is provided which is highly sensitive and specific, and is suitable as a clinical test for the determination of physiological substances and trace components in humoral fluid. The method...
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4690890 |
Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
At least two antigens in a sample may be detected using an immunometric dual sandwich assay containing an effective amount of at least one monoclonal antibody against each antigen, which antibodies...
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4683196 |
Method and materials for the identification of lipopolysaccharide producing microorganisms
The subject invention provides a means for the immunological detection of an entire class of microorganisms in clinical samples. The detection is accomplished by reaction of the clinical sample...
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4677080 |
Rapid particle agglutination test for enterotoxigenic bacteria
A rapid technique is disclosed for the identification of enteric bacteria which elaborate cholera-related heat-labile enterotoxin antigens which have the ability to cause diarrheal disease in man...
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4677055 |
Immunological detection of bacterial pathogens with antibody-containing magnetic gel
A process for the immunobacteriological detection of pathogenic germs possessing specific antigenic determinants, and a kit for carrying out the process, with the aid of a magnetic gel to which are...
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4666851 |
Specific mycoplasma membrane antigen and antibody and their clinical applications
A method to produce actively growing mycoplasma organisms in microcolonies and which have a high content of species specific membrane antigen, is disclosed. The specific membrane antigen can be...
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4663278 |
Agglutination dependent enzyme channeling immunoassay
A novel agglutination assay is provided which brings together through the intermediacy of the binding of specific binding pair members particles which differ by having different members of a signal...
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4652533 |
Method of solid phase immunoassay incorporating a luminescent label
A method is provided for solid phase immunoassay for quantitation of antigen, hapten or antibody analyte in liquid sample and alternatively for quantitation of analyte occuring on or attached to...
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4650751 |
Protected binding assay avoiding non-specific protein interference
A specific binding enzyme-resistant ligand assay test material, which material comprises (a) a solid phase incorporated with one partner of a specific binding pair comprising said ligand or a...
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4649105 |
Method of measuring biological ligand
A method of measuring a biological ligand comprises allowing to coexist a biologically active composition comprising an immobilization phase of a particular antibody or a particular ligand and an...
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4639419 |
Immunological color change test involving two differently colored reagent spots
A method and device for detecting an antigenic material in which the device comprises a test utensil having an indentation in which two reagent spots are placed, the first body being a dyed...
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4621048 |
Reagents containing an anti-ligand bound to an anti-enzyme and methods for employing said reagents in an immunoassy
The invention relates to a method and novel reagents for detecting a ligand in a biological sample. In the method, the sample is combined with (i) an enzyme or an enzyme bound to a first...
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4617264 |
Pretreatment method and composition
The method disclosed herein allows for the pretreatment of organisms, suspected of being a material of interest, prior to performing an assay for a determination thereof. The method comprises...
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4604364 |
Bioluminescent tracer composition and method of use in immunoassays
A tracer composition is described whereby a nonradioactive photon emitter is coupled to a ligand, antigen or antibody for use in various immunoassay methods of analysis. The photon emitters...
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