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7358043 |
Proteomic interaction and genomic action determinations in the presence of associated redox state conditions
Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are...
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7335515 |
(1→3)-β-D-glucan binding domain protein, measuring method using the substance and assay kit
A (1→3)-β-D-glucan binding protein, a fluorescence-labeled (1→3)-β-D-glucan binding domain protein, a (1→3)-β-D-glucan measuring agent comprising the same, a method for measuring...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7323299 |
Methods for in vivo diversification of single genes
Methods and compositions are provided for the efficient in vivo diversification of gene-products in filamentous fungi, starting from (but not limited to) two or more copies of a single gene...
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7314712 |
Systems for in vivo site-directed mutagenesis using oligonucleotides
This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The...
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7291454 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7285403 |
Xylose-fermenting recombinant yeast strains
Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as...
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7273747 |
Cell having amplified signal transduction pathway responses and uses therefor
The invention provides recombinant cells that have been engineered such that ligand stimulation of a receptor expressed by the cells leads to amplified signal transduction responses. In one...
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7270977 |
Polypeptides for identifying fungicidally active compounds
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
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7241905 |
Dioxin analogues and methods and kits for searching out dioxins-decomposing organisms or enzymes or dioxin-decomposing enzyme genes
The present invention provides a novel dioxin analogue for use in the search for organisms capable of degrading dioxin. The dioxin analogue is represented by the following chemical formula (1) or (2):
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7232664 |
Fermentation process using specific oxygen uptake rates as a process control
Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process...
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7229762 |
Proteomic screening for redox state dependent protein—protein interactions
This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to...
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7223533 |
Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the...
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7202356 |
Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
The regulatory sequences (i.e., promoter regions, introns and enhancers) associated with the Yarrowia lipolytica gene encoding fructose bis-phospate aldolase (FBA1) have been found to be...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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7157237 |
Antibodies for enzymes of the ω-oxidation pathway and methods relating thereto
The present invention provides antigenic peptides useful for the production of antibodies which selectively bind to an enzyme involved in the ω-oxidation of fatty acids and alkanes to...
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7148053 |
Heterologous G protein coupled receptors expressed in yeast, their fusion with G proteins and use thereof in bioassay
Expression vectors and yeast cells that contain a heterologous G protein-coupled receptor gene and a gene mutation that causes increased sensitivity to receptor activation or a gene mutation that...
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7144711 |
AGS proteins and nucleic acid molecules and uses therefor
A screening assay in yeast is disclosed wherein G-protein coupled-receptor independent activators and inhibitors of the pheromone pathway can be identified using a mammalian cDNA library. Novel...
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7129053 |
Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool
The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism comprising the following steps: (a) provision of an immunochromatographic test with a...
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7122330 |
High-throughput screening of expressed DNA libraries in filamentous fungi
The invention provides a method for the expression of exogenous DNA libraries in filamentous fungi. The fungi are capable of processing intron-containing eukaryotic genes, and also can carry out...
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7118855 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the...
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7105309 |
Yeast cells engineered to produce pheromone system protein surrogates and uses therefor
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a...
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7094593 |
Method for improving the function of heterologous G protein-coupled receptors
This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and...
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7091049 |
Enhanced diffraction-based biosensor devices
An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance...
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7090994 |
Methods of screening for introduction of DNA into a target cell
The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important...
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7090991 |
System for detection of a functional interaction between a compound and a cellular signal transduction component
The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the...
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7083941 |
Compositions and methods for gender sorting
A yeast based transactivation assay for gender sorting is disclosed.
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7083933 |
Methods for identification of modulators of OSGPR116 activity
This invention relates to the identification of fatty acid or lipid amides that decrease food intake in mammals, including fatty acid ethanolamides, as ligands for the G-protein coupled receptor...
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7056718 |
Polypeptides having oxaloacetate hydrolase activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having oxaloacetate hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7052882 |
Glucan derived from aspergillus
A glucan extracted by oxidation treatment of microorganism cells belonging to the genus Aspergillus under alkaline conditions; a glucan obtained by dissolving an aqueous solvent-insoluble...
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7052866 |
Method for evaluating the efficacy of an antifungal agent
A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered...
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7041464 |
Method for determining a gushing factor for a beverage
The invention relates to a method for determining a gushing factor for a beverage, in which method the quantity of hydrophobin is determined from the raw material of the beverage and/or from the...
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7033768 |
Reverse two-hybrid systems
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ...
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7033748 |
Identification of microbial polynucleotides expressed during infection of a host
The invention provides methods useful for identifying polynucleotides expressed in vivo by a microbe during infection of a host. Antibodies against antigens that are expressed by the microbe in...
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6994982 |
Isolating biological modulators from biodiverse gene fragment libraries
The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step...
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6977180 |
Biosensor
The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is...
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6974700 |
Kit for use in predicting refractory periodontal disease
A kit and method of predicting a refractory response in a subject diagnosed as having periodontal disease by measuring serum concentrations of actinomyces antibodies, streptococcal antibodies and...
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6929927 |
Method of evaluating antifungal agent
A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered...
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6916626 |
Detection of Candida
The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the...
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6913886 |
Fast and exhaustive method for selecting a prey polypeptide interacting with a bait polypeptide of interest: application to the construction of maps of interactors polypeptides
The present invention is directed to a method for selecting a prey polypeptide that is able to interact with a bait polypeptide of interest, to a prey polynucleotide encoding the prey polypeptide...
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6872540 |
Method and apparatus for distinguishing Crohn's disease from ulcerative colitis and other gastrointestinal diseases by detecting the presence of fecal antibodies to Saccharomyces cerevisiae
A method and apparatus for the differentiation of Crohn's disease from other gastrointestinal illnesses, such as ulcerative colitis and irritable bowel syndrome, using the presence of fecal anti-...
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6867004 |
Methods of using oxidized fungal antigens in antibody testing
The present invention relates to oxidized fungal antigens and methods of making and using thereof. More particularly, the present invention provides a method for producing an oxidized fungal...
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6855504 |
In vivo high throughput toxicology screening method
A high throughput toxicology screening method is provided. In the subject method, at least 10 different compound compositions are tested simultaneously. Each compound composition is tested by...
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6846622 |
Tagged epitope protein transposable element
A transposable element is provided that as a 3′ and a 5′ end. The transposable element includes a 5′ recombining site 5′ of a nucleic acid sequence encoding a selectable marker, a 3′...
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6830891 |
Methods for diagnosis of allergic bronchopulmonary aspergillosis
Methods for the diagnosis of ABPA in a human individual comprise determining if the individual carries antibodies reactive with one or more ABPA-related recombinant allergens, which one or more...
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6824996 |
Production of ascorbic acid
The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast...
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6815169 |
Identification and expression of a novel kinesin motor protein
The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for...
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6787300 |
Identifying lifespan-altering agents
Methods of isolating mutant yeast cells with increased life span, as well as mutant yeast cells isolated by the methods, are disclosed. Also described are methods of identifying agents which...
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6753151 |
Interactions of Ku polypeptides and applications thereof
Ku is a protein found in a wide range of organisms. It comprises two tightly-associated subunits termed Ku70 and Ku80. The present invention relates to the discovery and characterisation of an...
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6746837 |
Multiple drug resistance gene atrD of aspergillus nidulans
The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans . Vectors and transformed host cells comprising the multiple drug...
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