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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7358059 |
Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement
A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood...
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7354773 |
Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such...
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7354727 |
Method and apparatus for classifying B-lymphocytes
A B-lymphocyte classifying method includes the steps of (1) preparing a measurement sample by mixing a blood sample with a lysing reagent to lyse erythrocytes and to shrink the B-lymphocytes in the...
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7338809 |
Method for assaying whole blood
In a method for measuring an analyte, which comprises a reaction step of forming a reaction system including a sample containing whole blood, a first substance carried by a solid carrier and...
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7326579 |
Immunoassay method for lyzed whole blood
The present invention provides an immunoassay method in which blood can be measured even without pretreatment by means of a centrifuge etc. In the present invention, antibodies or antigens in a...
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7323315 |
Method for reducing effect of hematocrit on measurement of an analyte in whole blood
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the...
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7238784 |
Rh antibody
Rh antibody hybrids for use in testing red blood cells for the presence of one or more Rh factors. The Rh hybrid antibody may also be used in therapeutic procedures which require the use of Rh...
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7208284 |
Method for measuring polyamines in erythrocytes, diagnostic method and kit for measuring polyamines in erythrocytes
A method for measuring polyamines in erythrocytes in which a polyamine oxidase having a substrate specificity to spermine and spermidine or a polyamine oxidase having a substrate specificity to...
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7160723 |
Cell separation compositions and methods
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
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7157049 |
Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
The present invention is directed to optical bio-discs, methods, and optical disc drives for clinical diagnostics. The present invention is further directed to methods for determining the quantity...
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7033784 |
Method of producing an erythroid cell which is undifferentiated yet capable of expressing a heterologous protein
A method of producing an erythroid cell which is substantially undifferentiated but which is capable of expressing a heterologous protein under the control of a globin promoter thereof, which...
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7026131 |
Methods and apparatus for blood typing with optical bio-discs
This invention relates to clinical diagnostic assays, related optical bio-discs, and a disc-reading apparatus. The invention is directed to methods and apparatuses for performing immunohematology...
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7015006 |
Diagnostic test
An assay for detecting type IV cytosolic phospholipase A 2 (cPLA 2 ) or a protein immunologically homologous to type IV cPLA 2 , the assay comprising use of red blood cells, particularly for use in...
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6989240 |
Method for detecting hemolysis
This invention provides a method for determining the presence of hemolyzed erythrocytes in blood by detecting erythrocyte adenylate kinase in a serum sample from the blood. This invention also...
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6977156 |
Flow cytometry reagent and system
An improved reagent system for preparation of cells for flow cytometry having a physiologically compatible salt solution composition including a lysing agent, an agent for minimizing white blood...
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6955889 |
Simultaneous determination of forward and reverse ABO blood group
Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be...
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6911313 |
Process for discriminating and counting erythroblasts
A method for discriminating and counting erythroblasts comprises the steps of: (i) staining leukocytes in a hematologic sample by adding a fluorescent labeled antibody capable of binding...
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6893881 |
Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell...
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6858399 |
Test for oxidative stress using cell suspensions
This invention provides a method of measuring oxidative response of cells without recourse to preparation of cell culture. The process involves:
1) preparing suspensions of cells from a...
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6830895 |
Method and kit for typing feline blood
The present invention relates to a kit for determining feline blood type, wherein the kit includes a mixture comprised of a first monoclonal antibody and a second monoclonal antibody, wherein both...
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6824993 |
Antibodies that bind human prostate specific G-protein receptor HPRAJ70
The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to...
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6821790 |
Methods and apparatus for separation of biological fluids
A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte...
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6753153 |
Markers for identification and isolation of pancreatic islet α and β progenitors
The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic...
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6740527 |
Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood
Cyanide-free reagents for the determination of hemoglobin and leukocytes present in a blood sample comprise an aqueous solutions of at least one quaternary ammonium salt, preferably selected from...
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6733980 |
Diagnostic method for detection of molecular forms of eosinophilic cationic protein (ISO-ECPS)
Diagnostic methods comprise measuring specifically the level of at least one iso-eosinophilic cationic protein (iso-ECP) in a sample from an individual to be diagnosed, and comparing the measured...
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6713250 |
Identification of human allergens and T-lymphocyte antigens in vitro
The invention provides a method for screening a test compound for the ability of the test compound to induce a response from human naive T-cells. The method comprises admixing human naive T cells,...
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6677123 |
Process for detecting increased risk of fetal chromosomal abnormality
An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating α-fetoproteins present in the body fluid of a pregnant woman,...
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6654120 |
Synovial fluid control
A control reference material for the measurement of cells and crystals that are present in synovial fluid at different pathognomic conditions. Several possible suspending buffers for the control,...
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6623983 |
Apparatus and methods for capture and analysis of particulate entities
Apparatus and methods are disclosed which facilitate immobilization of magnetically labelled particulate entities, e.g., cells, preferably in a defined pattern, on a collection surface via binding...
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6607723 |
Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by...
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6586200 |
Method for detecting substances inhibiting the bacterial type III secretion mechanism and function of secretory proteins thereof
The present invention relates to a method for detecting substances specifically inhibiting a type III secretion mechanism and functions of the type III secretory proteins, within short time and...
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6537766 |
Ikaros isoforms and mutants
Specific Ikaros mutations, as well as the correlation of the presence of the specific Ikaros mutations and other wild-type non-DNA binding Ikaros isoforms with lymphoid cell abnormality is provided...
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6537760 |
Receptor binding assay for detecting TSH-receptor auto-antibodies
In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or...
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6514714 |
Method for immunobead flow cytometric detection of anti-HLA panel reactive antibody
The present invention provides an improved method for detection of panel reactive antibodies in serum of a subject against HLA class I antigens, which comprises the steps of adding serum from a...
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6475749 |
Rh hybrid antibody
Rh antibody hybrids for use in testing red blood cells for the presence of one or more Rh factors. The Rh hybrid antibody may also be used in therapeutic procedures which require the use of Rh...
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6465259 |
Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte
A method for quantitatively and/or qualitatively assaying an analyte in a sample, wherein the analyte is a receptor binding compound, has low detection limits equivalent to those of radioreceptor...
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6413727 |
Diagnosis for mutant APC by immunoassay
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous...
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6413716 |
Method for detection of human parvovirus and reagent therefor
A method for detection of human parvovirus B19, comprising the steps of: (1) bringing a sample into contact with fixed P-antigen positive red cells in a medium at pH 5.6±0.6; and (2) determining...
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6410696 |
Cyclosporin immunoassay
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring...
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6387622 |
Ligand-aminodextran-marker conjugates and uses thereof
Ligand-aminodextran-(phycobiliprotein or tandem dye) conjugates useful for detection of a desired target biological material by providing an enhanced fluorescent signal are described. Also...
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6372215 |
Monoclonal antibodies to human CD6
The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially...
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6359119 |
Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In...
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6358697 |
Intracellular pharmaceutical targeting
A method and composition to target compounds into cells such as eosinophils. A ligand for a CCR-3 eosinophil surface receptor is provided under conditions to bind to the receptor and cause...
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6331395 |
Prenatal diagnostic methods
A method of identifying embryonic or fetal red blood cells in a sample containiing maternal blood cells and embryonic or fetal red blood cells or both, the method comprising determining which cell...
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6330058 |
Spectrophotometric method and apparatus for blood typing
A method and apparatus for characterizing the type of a blood sample are provided wherein an optical density spectrum of the sample is collected over a predetermined wavelength range. A reference...
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6306615 |
Detection method for monitoring β tubulin isotype specific modification
This invention relates to monoclonal antibodies that recognize modified β-tubulin isotypes, methods of using such antibodies to detect modified β-tubulin isotypes, methods of using such...
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6303390 |
Method for antigen and antibody determination in bloodgroup serology
Method and test kit for assaying in a sample an analyte which is a bloodgroup antigen present on erythrocytes or an antibody binding to such a bloodgroup antigen. To that end, the sample is treated...
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6291249 |
Method using an apparatus for separation of biological fluids
A cell containing sample is separated into a cell containing portion and a substantially cell depleted portion, by mixing the sample with particles to produce a cell containing network, and...
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6287791 |
Multidimensional cell differential analysis
This invention relates to an improved method for the multi-parameter analysis of cells from peripheral blood or bone marrow. The method uses a nucleic acid dye, at least two fluorescently labelled...
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