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7392141 |
Method of preparing a modified granulocyte colony stimulating factor (G-CSF) with reduced immunogenicity
A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more...
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7390630 |
Method of identifying a compound that selectively inhibits cytokine-stimulated T cell induced production of TNF-alpha by monocytes
A method of identifying a compound with efficacy in the treatment of chronic inflammatory disease by testing the compound for an ability to selectively inhibit the ability of T ck cells to induce...
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7387882 |
Predictive assay for immune response
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7371537 |
Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte...
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7364869 |
Method of detecting antigen-specific T lymphocytes
The present invention provides a method of detecting antigen-specific T lymphocytes in a sample. The present invention further provides kits and systems for detecting antigen-specific T lymphocytes...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7361479 |
Assay
The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts...
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7358059 |
Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement
A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood...
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7354727 |
Method and apparatus for classifying B-lymphocytes
A B-lymphocyte classifying method includes the steps of (1) preparing a measurement sample by mixing a blood sample with a lysing reagent to lyse erythrocytes and to shrink the B-lymphocytes in the...
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7341840 |
Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
The present invention is directed to methods for the identification and uses of receptors that interact with anti-inflammatory compounds derived from eicosapentaenoic acid (EPA). The receptors are...
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7335351 |
Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7326577 |
Cell fixation and use in phospho-proteome screening
A new method of cell fixation using a mild denaturing heat and the fixative PERMIFLOW™ or similar fixative that preserves cell morphology, light scatter profiles, nucleic acid content, cell...
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7316932 |
Method for separating cells
The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense...
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7306927 |
Method of inducing immunity against stratum corneum chymotrytic enzyme
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
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7300763 |
Method of testing myelotoxicity with the use of flow cytometer
The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing...
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7294458 |
Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients
A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown...
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7279291 |
Polypeptides having a triggering NK activity and biological applications
The invention relates to polypeptides having a triggering NK activity and an amino acid sequence that is at least 80% identical over its entire length to the polypeptide having SEQ ID NO: 1, and...
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7279158 |
Methods for the treatment of inflammatory joint disease
The use of compounds that block complement component C5 or its active fragments C5 a and/or C5 b (such compounds collectively referred to as “C5 blockers”) to treat established joint...
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7273712 |
Methods and compositions for detecting compounds that modulate inflammatory responses
The present invention relates to compositions and methods for identification and development of compounds or therapeutic agents that treat pathophysiological conditions arising from inflammatory...
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7273711 |
Diagnosis of human glycosylation disorders
This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins,...
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7244579 |
Methods and materials for diagnosing unstable angina
The invention provides methods and materials for diagnosing an angina condition in a patient. Specifically, the invention provides methods and materials for classifying an angina condition as...
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7244573 |
Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic...
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7235392 |
Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
Cell preparations comprising a plurality of apoptotic EBV-transformed B lymphocytes and methods of producing cell preparations comprising a plurality of apoptotic EBV-transformed B lymphocytes. The...
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7223552 |
Myeloperoxidase, a risk indicator for cardiovascular disease
Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of...
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7217567 |
Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments
The present invention relates to methods for lyophilizing eukaryotic cells and isolating intact nucleic acids from such cells, and related kits for using the same.
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7217534 |
Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic...
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7214494 |
Method of screening for substance preventing or treating diseases in association with malfunction of IL-6 family cytokine receptor malfunction
The invention provides a method of screening for substances preventing or treating diseases in association with IL-6 family cytokine receptor malfunction, which comprises using a transgenic mouse...
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7211408 |
Recombitope peptides
The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes...
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7211407 |
High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
Disclosed are high throughput assay systems and methods for identifying agents that alter the level of surface expression of integral membrane proteins, such as cardiac ion channels, in mammalian...
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7208299 |
Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a...
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7205119 |
HA-1 antigen
A peptide sequence of the so-called minor H antigen. The minor H antigens are associated with Graft versus Host disease. The peptide and its derivatives find many uses in bone marrow...
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7205113 |
Methods of modulation of the immune system
Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signaling, T cell proliferation, and induction of T cell death. Methods of...
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7198946 |
Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by...
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7192724 |
Method for differentiating irritable bowel syndrome from inflammatory bowel disease (IBD) and for monitoring persons with IBD using total endogenous lactoferrin as a marker
A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces,...
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7186515 |
Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
The present invention relates to the use of alpha (2) macroglobulin (“α2M”) receptor as a heat shock protein receptor, cells that express the α2M receptor bound to an HSP, and antibodies and...
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7169571 |
Methods for measurement of lymphocyte function
A method for measuring the responses of sets or subsets of lymphocytes to mitogens or antigens in a sample is disclosed comprising incubating a population of cells with a mitogen or antigen,...
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7169570 |
Method to identify regulators of cellular activation using Bcl10
Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates...
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7169564 |
FKBP51/52 and CyP40-mediated mammalian hair growth
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.
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7160723 |
Cell separation compositions and methods
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
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7157049 |
Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
The present invention is directed to optical bio-discs, methods, and optical disc drives for clinical diagnostics. The present invention is further directed to methods for determining the quantity...
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7144569 |
Diagnosis of coeliac disease using a gliadin epitope
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope...
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7141379 |
Method of suppressing differentiation by administering a human serrate-1 polypeptide
A method for suppressing differentiation of undifferentiated blood cells in vivo by contacting the cells in vitro with a serrate-1 peptide, thereby suppressing differentiation of the cells.
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7135302 |
Method for predicting transplant rejection
The present invention relates to a method for predicting whether or not transplant recipients are likely to reject tissue allografts. It is based, at least in part, on the discovery that, based on...
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7132255 |
Identification of compounds that bind biliary glycoprotein and affect cytotoxic T lymphocyte activity
The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary...
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7129056 |
Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular...
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7129055 |
Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was...
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7129037 |
Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells....
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