|
Match
|
Document |
Document Title |
|
|
7390629 |
Tumor-activated prodrug compounds and treatment
Methods of screening and identifying tumor-activated prodrug forms of therapeutic agents are described.
|
|
|
7390628 |
Microparticle-based diagnostic methods
The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the...
|
|
|
7387881 |
Detection and treatment of cancers of the liver
The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor...
|
|
|
7384764 |
Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine
Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the...
|
|
|
7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
|
|
|
7378253 |
Methods of therapy and diagnosis using immunotargeting of CD84Hy1-expressing cells
Certain cells, including types of cancer cells such as lymphomas, are capable of expressing high levels of CD84Hy1. Immunotargeting using CD84Hy1 polypeptides, nucleic acids encoding for CD84Hy1...
|
|
|
7378247 |
Neoplasm-specific polypeptides and their uses
The present invention features novel polypeptides and methods of using these polypeptides in the diagnosis, detection, monitoring, and treatment of neoplasms in a mammal, e.g., a human.
|
|
|
7374936 |
Method and means for site directed therapy
The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates...
|
|
|
7374875 |
Peptides having affinity for the gp120 viral protein and use thereof
The present invention relates to a family of peptides exhibiting high affinity and specificity for the viral protein gp120, to methods for producing these peptides, and to the use of these peptides.
|
|
|
7371562 |
Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
|
|
|
7368255 |
RUNX3 gene showing anti-tumor activity and use thereof
The present invention relates to a RUNX3 gene showing anti-tumor activity which is essentially involved in TGF-β dependent-programmed cell death (apoptosis) and use thereof. In addition, the...
|
|
|
7368254 |
Lipid-based systems for targeting diagnostic agents
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from...
|
|
|
7368252 |
Agglutination accelerator for immunological measurement
An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known...
|
|
|
7368098 |
Use of biomolecular targets in the treatment and visualization of tumors
The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor...
|
|
|
7364921 |
Method and apparatus for separating biological materials and other substances
A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands...
|
|
|
7364868 |
Krüppel-like transcriptional factor KLF4/GKLF and uses thereof
The present invention proivdes methods of identifying new carcinoma oncogenes or analyzing functions of known carcinoma oncogenes by transformation of RK3E cells. Also provided are methods of using...
|
|
|
7364862 |
Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.
|
|
|
7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
|
|
|
7361511 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting,...
|
|
|
7361336 |
Methods of cancer therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
|
|
|
7358061 |
Methods of diagnosing thyroid carcinoma
Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these...
|
|
|
7358060 |
Method for monitoring and prognosis of disease course of gastrointestinal tumors
The present invention provides a method for diagnosis, monitoring and prognosticating the disease course of gastrointestinal tumors, comprising determining the level of a cyclin dependent kinase...
|
|
|
7358059 |
Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement
A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood...
|
|
|
7358046 |
Sensitivity test to predict efficacy of anti-cancer therapies
The present disclosure provides methods for determining the sensitivity of cancerous cells to various anti-cancer therapies and predicting the efficacy of these therapies. Specifically, the present...
|
|
|
7354999 |
PRO1481 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7351811 |
Gene SCC-112 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule....
|
|
|
7348152 |
Rhamnose binding protein
An isolated RBP with at least one of the following characteristics:
a) a molecular weight of approximately 65-70 kDa and more preferably 66-69 kDa; b) a pI of greater than 10 or less than 3;...
|
|
|
7344829 |
Methods for detecting the efficacy of anticancer treatments
Methods for determining the effectiveness of anticancer agents by determining and comparing growth factor receptor phosphorylation levels in samples obtained by non-invasive procedures before and...
|
|
|
7339033 |
PRO1481
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7338767 |
Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma
Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be...
|
|
|
7335467 |
Breast cancer antigens
The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses...
|
|
|
7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
|
|
|
7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
|
|
|
7332287 |
Methods and compositions for diagnosing breast cancer
Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights...
|
|
|
7332280 |
Classification of patients having diffuse large B-cell lymphoma based upon gene expression
Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to...
|
|
|
7329502 |
ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is...
|
|
|
7323312 |
Tumor marker for urothelial carcinoma
This invention relates to a method for detecting urothelial carcinoma using an antibody that specifically reacts with a calreticulin protein or a fragment thereof and immunoassaying a calreticulin...
|
|
|
7321881 |
Methods and systems for predicting occurrence of an event
Embodiments of the present invention are directed to methods and systems for training a neural network having weighted connections for classification of data, as well as embodiments corresponding...
|
|
|
7316932 |
Method for separating cells
The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense...
|
|
|
7316907 |
14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types
Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are...
|
|
|
7316906 |
CD38 as a prognostic indicator in B cell chronic lymphocytic leukemia
The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression...
|
|
|
7314622 |
Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic...
|
|
|
7306926 |
Method for detecting carcinomas in a solubilized cervical body sample
The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a...
|
|
|
7306910 |
Breast cancer prognostics
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as...
|
|
|
7303740 |
Methods for the diagnosis and treatment of breast cancer
The present invention provides a method for diagnosing breast cancer in a subject. The present invention also provides a method for treating breast cancer in a subject. Finally, the present...
|
|
|
7300765 |
SC6 for diagnosis of cancers
The present invention relates to new uses of Solute Carrier 6 (SC6), a taurine transporter, in the diagnosis, screening, treatment and prophylaxis of hypoxia related conditions e.g. cancer....
|
|
|
7294471 |
Method for purifying cancer-specific proliferating cell nuclear antigen
A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
|
|
|
7291475 |
Methods of expressing integrin β6 subunits
The present invention provides substantially pure integrins containing a novel β subunit designated as β 6 . The novel β 6 subunit forms heterodimers with α v and α f . Methods of...
|
|
|
7291462 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
|
|
|
7291454 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
|