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6905833 |
Method of diagnosing breast cancer using nipple fluid
Methods and kits for detecting breast cancer or a high risk of breast cancer by measuring bFGF in nipple fluid from subjects compare the levels of bFGF in samples from test subjects with the levels...
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6900029 |
Method of selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation
A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have...
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6900022 |
Prostate cancer-specific marker
This invention provides cDNA encoding a prostate-cancer specific marker, Repro-PC-1.0, Repro-PC-1.0 polypeptides and methods for use in diagnosis and therapy.
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6893881 |
Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell...
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6893831 |
Immunoassay of PIVKA-II
The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing...
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6887975 |
Peptides derived from STEAP1
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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6884577 |
Methods for screening compounds for estrogenic activity
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
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6881548 |
Methods and kits for diagnosing tumorigenicity and determining resistance to the antineoplastic effects of antiestrogen therapy
Methods and kits for diagnosing tumorigenicity and for determining whether a cancer patient is resistant to the pharmacological effects of antiestrogen therapy. Increased levels of the PCDGF (GP88)...
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6878526 |
Treating cancer
Provided is a method for the diagnosis of a cancerous or pre-cancerous state in a subject, comprising testing a sample comprising cells or an extract therefrom for the co-elevation of CDK1 and...
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6875579 |
Device for binding molecules, molecular groups, molecular parts and/or cells
The present invention relates to a device for binding molecules, molecular groups, molecular parts and/or cells contained in a liquid to target structures, the device having at least one object...
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6875575 |
Diagnostic methods for neoplasia
This invention provides a method for diagnosing a patient with neoplasia.
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6872517 |
Early diagnosis of cancerous and precancerous conditions by leakage of signature peptides and carbohydrates into the bloodstream
The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a...
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6872518 |
Methods for selecting polynucleotides encoding T cell epitopes
The present invention relates to methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such...
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6872543 |
Method for assessing the risk of peptic ulcer, comprising the steps of determining quantitatively the concentrations of pepsinogen I (PGI) and gastrin-17 in a serum sample
The present invention concerns a method for assessing the risk of peptic ulcer by determining the presence and topographic phenotype of gastritis in an individual, by determining quantitatively the...
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6869592 |
Method and antibody for imaging lung cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.
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6866994 |
Noninvasive intraductal fluid diagnostic screen
Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is...
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6863892 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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6864047 |
IL1-β: a new target for myeloma therapy
Diagnostic methods for the detection of multiple myeloma (MM) and the identification of high-risk patients with multiple myeloma-related plasma proliferative disorders, such as MGUS or SMM, likely...
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6852483 |
Predicting survival of patients with squamous cell carcinoma
The invention relates to methods of determining a relative probability of survival for a subject with squamous cell carcinoma by obtaining a biological sample from a subject with squamous cell...
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6846642 |
Methods of detecting cancer based on prostasin
The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of...
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6838249 |
Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore
The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel.
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6838248 |
Compositions and methods for detecting pre-cancerous conditions in cell and tissue samples using 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine
Presented is a method to detect precancerous states in mammalian cell and tissue samples comprising incubating a sample with solubilized 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine (TCPP),...
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6835549 |
Immunoassay method for the diagnosis of gastric intestinal metaplasia associated with gastric carcinoma
This invention pertains to an in vitro immunoassay method for diagnosing human gastric intestinal metaplasia which comprises the steps of (a) contacting a gastric tissue sample of a subject...
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6828109 |
Methods for detecting an analyte of interest using catalyzed reporter deposition of tyramide
The present invention relates to methods of staining cells for flow cytometry, using catalyzed reporter deposition and amplification staining. A catalyzed reporter deposition or an analyte...
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6824995 |
Diagnostic for metastatic prostate cancer
The present disclosure provides methods for the diagnosis of metastatic prostate cancer and/or the prediction of the metastatic ability of prostate cancer in prostate biopsy tissue. Metastatic...
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6824986 |
Methods for measuring in vivo cytokine production
The present invention involves techniques for evaluating in vivo cytokine production through the in vivo capture of secreting cytokines by labeled cytokine-binding reagents, followed by in vitro...
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6821790 |
Methods and apparatus for separation of biological fluids
A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte...
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6821740 |
Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells
Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are...
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6821784 |
Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy
Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patient's stool is...
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6818412 |
Human growth factors
The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1,...
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6815170 |
Methods for lymph node identification
The present invention describes a method for identification of lymph nodes and the presence or absence of lymph node metastases as an important prognostic factor in early stage cancers of all...
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6811968 |
Method of monitoring cell motility and chemotaxis
The present invention discloses a method of monitoring chemotaxis or chemoinvasion comprising: providing a device for monitoring chemotaxis. The device includes a support member; a top member...
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6806056 |
Fluorescent capture assay for kinase activity employing an anti-phosphotyrosine antibody as both the capture agent and detecting agent
A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting...
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6800731 |
Human oncogene induced secreted protein I
The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the...
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6800449 |
High throughput functional proteomics
A method is disclosed which provides a high throughput method for assigning plausible functions to unknown sequence entries in a particular database. The method was used herein to identify lectin...
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6794151 |
c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence
A method of diagnosing the presence or absence of cancer in a human patient is disclosed. In one embodiment, this method comprises the steps of examining patient tissue for the CRD-BP expression...
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6790614 |
Selectable cell surface marker genes
The present invention concerns a method of identifying genetically modified mammalian cells using a mutated protein-tyrosine kinase receptor (PTKR) as a selectable marker in mammalian cells....
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6787323 |
VEGF responsive cell-based assay for determining VEGF bioactivity
A VEGF responsive cell-based assay for determining VEGF bioactivity is disclosed. The assay utilizes established signal transduction pathways in a method for determining VEGF bioactivity in a sample.
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6780596 |
Methods for determining the activity of complex mixtures
According to the present invention, the biological or pharmacological activity of a test material like a plant or herbal material, an extract of a plant or herbal material, a natural or synthetic...
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6777194 |
Monoclonal antibodies against human protein Mcm3, process for their production, and their use
The present invention relates to monoclonal antibodies against the human Mcm3 protein, hybridoma cell lines that produce such antibodies, procedures for the production and their use, pharmaceutical...
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6770445 |
Methods and compositions for diagnosing carcinomas
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin...
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6767712 |
Models of prion disease
The present invention provides a novel PrP protein, and nucleic acids encoding this protein, where the PrP protein is characterized in vivo by 1) incomplete glycosylation relative to glycosylation...
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6762032 |
Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response
Provided are methods, and assay kits, and compositions useful for generating an indicator of a disease condition selected from the group consisting of multiple sclerosis (MS), a pro-MS immune...
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6760612 |
Method for detecting lymphoid tissue in tumor progression
A method is provided for detecting lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an...
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6756201 |
Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1
The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic methods and gene therapy approaches utilizing reagents derived from the nucleotide and...
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6753153 |
Markers for identification and isolation of pancreatic islet α and β progenitors
The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic...
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6753154 |
Human AZU-1 gene, variants thereof and expressed gene products
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of...
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6750327 |
Compositions and method for determining the presence of human PTTG peptide in a sample
Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids encode them. Examples are the human and rat...
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6746848 |
Protein quantitation with cell imaging densitometry
A method for quantitating cellular proteins in tissue, by means of a cell imaging densitometer in conjunction with immunohistological staining and a reference standard, is provided. Unlike prior...
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6746846 |
Methods for diagnosing lung cancer
Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or...
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