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7083933 |
Methods for identification of modulators of OSGPR116 activity
This invention relates to the identification of fatty acid or lipid amides that decrease food intake in mammals, including fatty acid ethanolamides, as ligands for the G-protein coupled receptor...
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7078180 |
Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors
Methods, compositions and kits which employ one or more ZEB specific detection reagents for detection and localization of ZEB associated molecules in tumor cells are disclosed. Also provided are...
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7071168 |
Anti-cancer compounds and methods related thereto
The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula:
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7070924 |
Method of detecting cell death and detection reagent
A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in...
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7070943 |
Detection of protein conformations in single cells
Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are...
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7056746 |
Array cytometry
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7056689 |
Methods of treating and detecting cancer using viruses
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The...
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7056690 |
Detection of dysplastic or neoplastic cells using anti-MCM2 antibodies
Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the...
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7052859 |
MUCIN 4 expression as a marker for pancreatic cancer
Methods are provided for the diagnosis of pancreatic cancer.
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7052832 |
Methods for the treatment of cellular proliferative disorders
The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using...
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7049084 |
Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore
The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel.
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7037668 |
Methods for the treatment and diagnosis of tumorigenic and angiogenic disorders using 32616
The present invention relates to methods and compositions for the treatment and diagnosis of tumorigenic and/or angiogenic disorders, including, but not limited to, lung tumors, breast tumors,...
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7037667 |
Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-related, cell membrane associated and secreted serine protease...
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7033746 |
NES-1 polypeptides, DNA, and related molecules and methods
Disclosed is substantially pure NES1 polypeptide and purified DNA, vectors, and cells encoding that polypeptide. Also disclosed are methods for carcinoma detection and treatment using the NES1...
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7029859 |
Sequences for targeting metastatic cells
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to...
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7029866 |
Cancer diagnosis by the measurement of Nup88 in body samples
The invention is directed to a method of diagnosis of the existence and/or the pathological developmental stage and/or the grade of malignancy of carcinomas and/or sarcomas in mammals characterized...
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7026132 |
Method of monitoring the effect of Cathepsin S inhibitors
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant...
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7026127 |
Reg-like protein
Methods of detecting the presence of a tumor or a cancerous condition includes detecting the expression of RELP proteins, related polypeptides and proteins, or nucleic acid molecules indicative of...
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7026148 |
DAP-kinase related protein
A new protein, which is a novel homologue of DAP-kinase, has been isolated. This novel calmodulin-dependent kinase is a cell death-promoting protein functioning in the biochemical pathway which...
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7014996 |
Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers
The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating gynecologic cancers including uterine, breast, endometrial and...
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7015306 |
Labeled neurotensin derivatives
Peptide analogs of neurotensin are disclosed which are resistant to enzymatic degradation and which retain high binding affinity for neurotensin receptors. Pharmaceutical compositions of these...
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7011950 |
Detecting recurrence and high stage bladder carcinoma
Analysis of nucleophosmin/B23 mRNA expression provides sensitive, quantitative, rapid and specific analysis to detect cancer cells in tissues for predicting and monitoring recurrence and high stage...
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7011940 |
Quality control for cytochemical assays
The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a...
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7001735 |
Glucose transporter/sensor protein and uses thereof
The present invention provides a method for determining whether a subject has a defect in cell proliferation. The present invention further provides a method for assessing the efficacy of therapy...
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6998234 |
Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially...
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6998242 |
Method of diagnosing metabolic bone diseases
A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor....
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6995018 |
Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H
The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement...
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6994976 |
Tr3-specific binding agents and methods for their use
Biologically active TR3-specific binding agents and methods for their use are disclosed. The biologically active TR3-specific binding agents are useful for inhibiting the proliferation of cells...
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6994851 |
Method of inducing a CTL response
A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained...
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6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
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6982151 |
Design of novel assays based on the newly found role of dystroglycan and alpha-dystroglycan proteolysis in tumor cell growth
The invention provides method for assessing tumorigenicity of mammalian cells by assaying the proteolytic fragments of 120-130 kD alpha-dystroglycan in medium surrounding mammalian cells.
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6982150 |
System and method for identifying proteins involved in force-initiated signal transduction
The present invention relates to a cytoskeletal system composed of purified components which allow for the identification of key proteins involved in mechanotransduction. The system comprises a...
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6979574 |
Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
The invention relates to a new process for detecting analytes or binding reactions using measurement of the double refraction, as well as the use of the compounds in analytical chemistry that are...
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6979447 |
Immunomodulation and effect on cell processes relating to serotonin family receptors
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to...
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6972180 |
Method of diagnosing and monitoring malignant breast carcinomas
A panel of biomarkers for the diagnosis and treatment of breast cancer was examined in the saliva of a cohort of 1) healthy women, 2) women with benign lesions of the breast and 3) women with...
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6972181 |
Differential diagnosis of cancer and other conditions based on expression of p63
This invention relates to methods of distinguishing among various types of differentiated and undifferentiated epithelial carcinomas, and non-epithelial carcinomas, by detecting the presence of p63...
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6962808 |
Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors
There is provided an apparatus for screening pharmacological agents for agents which induce regression of cancer. The apparatus includes an evanescent sensing device, at least one sensor having...
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6962789 |
Method for quantitating a protein by image analysis
The present invention provides a method for determining expression levels of one or a multiplicity of target proteins in a tissue or cell sample.
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6960447 |
Isolation of membrane bound ligand-specific complexes
A method to recover receptors without removing microenvironmental components associated with them is described. The membranes containing the receptors are first associated with ligand-coupled solid...
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6953668 |
Prostate-specific membrane antigen
This invention provides for an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention provides for nucleic acid probes which specifically...
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6949350 |
Chemosensitivity determination using phosphatidylserine
A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the cells are incubated essentially...
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6949339 |
Method of diagnosing, monitoring, and staging colon cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating colon cancer.
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6939714 |
Epithelial cell growth inhibitors
Epithelial cell growth inhibitors differentially express in normal and cancerous epithelial cells. The ECGI proteins and nucleic acid sequence encoding them are useful in the diagnosis and...
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6936424 |
Materials and methods for detection and treatment of breast cancer
The invention provides a wide range of methods and compositions for detecting and treating breast cancer in an individual. Specifically, the invention provides target breast cancer-associated...
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6936260 |
Vaccine composition
A tuberculosis (TB) vaccine composition is disclosed. The composition comprises, as adjuvant, one or more substances selected from a) monoglyceride preparations having at least 80% monoglyceride...
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6929920 |
Diagnosis of chronic obstructive pulmonary disease
Methods of determining Chronic Obstructive Pulmonary Disease (COPD) severity in patients which comprises measuring the concentration of soluble E-cadherin (sE-cadherin) in the patient's urine...
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6929918 |
Method for diagnosing an adenocarcinoma or a benign prostate pathology
The invention concerns a method for diagnosing a prostate adenocarcinoma in a male human patient without performing a prostatic biopsy, using the PSA protein (prostate specific antigen) present in...
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6927035 |
Antiuracil monoclonal antibody
A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying...
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6924117 |
Human RRP sequences and methods of use
Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the...
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6911315 |
Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular...
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