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7341870 |
Dendritic cell line
The invention relates to plasmacytoid dendritic human cell lines and methods for producing the cell lines. More specifically, the invention relates to the plasmacytoid dendritic human cell line...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7335477 |
Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been...
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7294477 |
Allergen and treatment
The present invention is related to novel nucleoli sequences encoding a louse allergen and a methods for diagnosing, treating and preventing lice infestation and associated allergic disease with...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7214531 |
Pressure transduced chemical assay and method
An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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7166290 |
Methods for producing oocysts
The present invention provides improved methods and compositions for producing oocysts. The oocysts produced according to the invention find use in the manufacture of vaccines. In preferred...
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7163799 |
Neuromedin U receptor NMUR2 and nucleotides encoding it
A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain....
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7153819 |
Stabilization of antibodies or fragments thereof
There is provided an antibody granule, consisting essentially of one or more antibodies, or fragments derived thereof, granulated with an alkali metal salt. Also provided is a process for preparing...
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7094879 |
Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof
The present invention relates to a genetically engineered P30 antigen and a combination or mixture of antigens (e.g., the genetically engineered P30 antigen and P35) that may be used in the...
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7094576 |
Methods and compositions for detecting larval Taenia solium with a cloned diagnostic antigen
Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium ...
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7056518 |
Malarial pre-erythrocytic stage polypeptide molecules
Polypeptide molecules containing at least 10 consecutive amino acids of the amino acid sequence shown in FIG. 2, representing the LSA3 antigen, the following peptides being excluded:
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7052858 |
Diagnostic assays for detection of Cryptosporidium parvum
This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and...
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7008774 |
Practical serological assay for the clinical diagnosis of leishmaniasis
Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are...
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6979574 |
Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
The invention relates to a new process for detecting analytes or binding reactions using measurement of the double refraction, as well as the use of the compounds in analytical chemistry that are...
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6969602 |
Production of an immunovariant strain of Eimeria maxima contributes to strain cross-protection with other Eimeria maximas
An immunovariant strain of Eimeria maxima was isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection.
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6955886 |
Scintillation proximity assay for the detection of peptidoglycan synthesis
The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan...
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6911315 |
Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular...
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6872539 |
Analytical system based upon spore germination
An analytical system for rapid detection and identification of different analytes directly from a test sample by mixing test material with a germinogenic source and enzyme-free spores, allowing the...
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6855504 |
In vivo high throughput toxicology screening method
A high throughput toxicology screening method is provided. In the subject method, at least 10 different compound compositions are tested simultaneously. Each compound composition is tested by...
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6855319 |
Gene encoding merozoite protein of Babesia caballi, recombinant protein obtained therefrom and utilization thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6790630 |
DNA and protein from Dirofilaria immitis
In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known...
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6756043 |
Compositions and methods for detecting adult Taenia solium
Compositions and methods for the detection of adult Taenia solium and the diagnosis and treatment of T. solium infection are described. The compositions contain one or more adult T. solium ...
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6737237 |
Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components
This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally...
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6730307 |
Anti-cryptosporidium parvum preparations
Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum . A high molecular weight glycoprotein antigen isolated from C. parvum , capable of binding...
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6716591 |
B. burgdorferi polypeptides
Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof....
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6716590 |
Compositions comprised of antigenic factors associated with malaria parasites, and process for making same
A method for the solubilization and recovery of plasmodial parasite protective antigenic factors from associated starting plasmodial parasite material, comprising forming an aqueous suspension of...
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6713250 |
Identification of human allergens and T-lymphocyte antigens in vitro
The invention provides a method for screening a test compound for the ability of the test compound to induce a response from human naive T-cells. The method comprises admixing human naive T cells,...
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6710166 |
41 kDa Cryptosporidium parvum oocyst wall protein
Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium...
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6706490 |
Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen
A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the...
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6699674 |
Expression and refolding of truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi . The invention is useful for detecting prior...
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6682900 |
Serological diagnosis of Chagas' disease
A chemiluminescent (CL)-ELISA method with purified and complex antigens of Trypanosoma cruzi is proposed for the specific and sensitive diagnosis of Chagas' disease in patients and blood bank...
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6670197 |
Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
This method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of fragments of target analyte cancer cells which are circulating...
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6660264 |
Treatment of intracellular infection
An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery...
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6653135 |
Dynamic protein signature assay
An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a...
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6599691 |
Rapid immunoassay to detect infection with Mycobacterium tuberculosis
A rapid, non-invasive, semi-quantitative immunoassay of saliva has been developed to aid in the diagnosis of diseases, e.g., using saliva to detect subjects actively or previously infected with ...
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6596502 |
Kit and method for detecting fecal parasites
The invention concerns a home kit and a method for detection of the presence of a fecal parasite in a stool.
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6589753 |
Determining cytoplasmic MSP-1 concentration to aid in diagnosis and prognosis of malignant tumors
An improved method of performing immunohistochemical staining on a tissue sample to determine the presence of cytoplasmic tumor marker Metallopanstimulin in cells in the tissue sample. The method...
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6589752 |
Recombinant antigen of Taenia solium metacestodes
This invention is directed to an isolated DNA sequence encoding an antigen of Taenia solium metacestodes. A 10 kDa antigen of Taenia solium metacestodes (TSM) has been shown to be specific for...
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6569433 |
Compounds and methods for the diagnosis and treatment of B. microti infection
Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B....
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6489148 |
Immunoassay for equine protozoal myeloencephalitis in horses
An immunoassay for Sarcocystis neurons antibodies in equines is described. The immunoassay uses blocking of Sarcocystis antigens by antibodies to Sarcocystis sp. other than Sarcocystis neurona ...
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6479248 |
Process and agent for detecting antibodies against Treponema pallidum
A method and agent for antibodies against Treponema pallidum are provided. The method involves gene-amplifying and cloning a selection of recombinant antigens. The selection of recombinant...
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6475747 |
Method for detecting Cryptosporidium parvum oocysts
Methods for detecting parasites, such as Cryptosporidium parvum , in turbid and non-turbid samples by solubilizing molecular markers or antigens of the parasite. The molecular markers are...
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6465259 |
Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte
A method for quantitatively and/or qualitatively assaying an analyte in a sample, wherein the analyte is a receptor binding compound, has low detection limits equivalent to those of radioreceptor...
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6458922 |
Antigens and immunoassays for diagnosing Chagas' disease
Transfusion of contaminated blood has become the major route of transmission for Chagas' disease. Current screening tests are insensitive and yield conflicting results, while confirmatory assays do...
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6458581 |
Process for the in vitro culture of different stages of tissue parasites
The present invention provides a method for carrying out in vitro the complete developmental sequence culture of tissular parasites, which includes culturing the parasites in a totally defined...
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6444436 |
Evacuated container assembly for analysis of a blood sample for the presence or absence of rare events
A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of target cancer cells and/or hematologic progenitor cells, or other...
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6436638 |
Cryptosporidium detection method
A method for selectively detecting the presence of C. parvum organisms in a sample. A method for selectively detecting the presence of C. parvum organisms and for detecting the presence of G....
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