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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390625 |
Apoptosis-associated protein and use thereof
The present invention provides a partial peptide comprising the functional domain of a protein comprising an amino acid sequence which is the same or substantially the same as an amino acid...
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7387880 |
Method for monitoring resting and activated platelets in unfixed blood samples
The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the...
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7384794 |
Micro-devices and analytical procedures for investigation of biological systems
Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the...
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7384755 |
Cell-based assay for G-protein-coupled receptor-mediated activity employing a mutated cyclic nucleotide-gated ion channel and a membrane potential dye
Disclosed are compositions and methods for their use, such as in identifying G-protein-coupled receptors, ligands and compounds that modulate the activities of G-protein-coupled receptors. The...
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7384753 |
Growth differentiation factor-11
Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. The invention provides a method for identifying a compound that affects GDF-11...
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7384752 |
DNA encoding a human imidazoline receptor and ligand binding assay employing same
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7378253 |
Methods of therapy and diagnosis using immunotargeting of CD84Hy1-expressing cells
Certain cells, including types of cancer cells such as lymphomas, are capable of expressing high levels of CD84Hy1. Immunotargeting using CD84Hy1 polypeptides, nucleic acids encoding for CD84Hy1...
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7378252 |
Process for identifying modulators of G-protein-coupled receptors
The invention relates to a widely applicable process for identifying chemical compounds, which modulate G-protein-coupled receptors, by means of novel hybrid G-proteins with broad receptor...
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7375207 |
Galanin receptor 2 proteins and nucleic acids
The present invention is directed to galanin receptor 2 (GAL-R2) proteins and nucleic acids.
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7374895 |
Guanosine triphosphate (GTP) binding protein-coupled receptor proteins that bind histamine and are expressed in the brain
A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA...
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7374890 |
Methods for identifying compounds that modulate ΔTRα2 activity
Truncated thyroid hormone receptors ΔTRα1 and ΔTRα2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering...
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7371562 |
Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7371537 |
Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte...
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7371535 |
Processes for determining compounds that interact with snorf33 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors,...
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7368277 |
Method for assay of antibodies and antibody assay device
The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the...
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7368253 |
Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the...
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7368252 |
Agglutination accelerator for immunological measurement
An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known...
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7364921 |
Method and apparatus for separating biological materials and other substances
A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands...
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7364867 |
Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells...
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7361517 |
Real time method of detecting acute inflammatory conditions
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage...
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7361462 |
Method for efficiently determining a DNA strand break
The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors...
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7358059 |
Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement
A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood...
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7358057 |
QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
The present invention relates e.g., to QM-7 or QT-6 cells comprising a heterologous mutant nicotinic α7 acetylcholine receptor and/or a nucleic acid encoding it, or a fragment or variant thereof....
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7355013 |
PRO6017 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7354726 |
Screening method
The present invention intends to provide a screening of agonist/antagonist and the like. Specifically, the invention provides a method of screening a compound or its salt that alters the binding...
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7354722 |
Modulators of Smurf and BMP/TGFβ signaling pathways
This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases have been named Smurf1 and...
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7348156 |
7B2 knockout transgenic animals as models of endocrine disease
In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous...
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7348155 |
Method for identifying compounds for treating aging processes in the coronary circulatory system
The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or...
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7344845 |
Olfactory receptor for isovaleric acid and related malodorants and use thereof in assays for identification of blockers of malodor
A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying...
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7344829 |
Methods for detecting the efficacy of anticancer treatments
Methods for determining the effectiveness of anticancer agents by determining and comparing growth factor receptor phosphorylation levels in samples obtained by non-invasive procedures before and...
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7342108 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine...
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7341849 |
Polynucleotides encoding SREB1 receptor
This invention belongs to the genetic engineering field, and provides novel G protein-coupled receptor family proteins SREB1, SREB2 and SREB3 expressed in the central nervous system, genes coding...
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7338773 |
Multiplexed assays of cell migration
Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and/or microplates.
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7338772 |
G-protein coupled receptor ligands and methods
The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for...
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7338771 |
Use of specific T2R taste receptors to identify compounds that block bitter taste
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to...
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7338769 |
Methods for identifying agonists of cypin
Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders.
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7338767 |
Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma
Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7335467 |
Breast cancer antigens
The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7332292 |
Constitutively translocating cell line
The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which...
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7332291 |
Methods of identifying modulators of ligand binding to ChemerinR polypeptides
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the...
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7329501 |
Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7323314 |
Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
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7321829 |
Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
The present invention is related to a method for the identification and/or the quantification of a target compound obtained from a sample, preferably a biological sample, comprising the steps of...
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7320873 |
Use of antibodies against specific MHC-peptide complexes
The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune...
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7320872 |
Ependymal neural stem cells and method for their isolation
The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3,...
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