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7465555 |
Early detection of sepsis
Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis.
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7465552 |
Patched genes and uses related thereto
Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated...
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7465549 |
Methods for identifying agents that bind a levetiracetam binding site (LBS) or compete with LEV binding to a LBS of a synaptic vesicle protein 2 (SV2)
The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which...
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7459279 |
Binding assay employing IGS4, a human G-protein coupled neuromedin receptor
The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such- polynucleotides and polypeptides, and to their production. More particularly,...
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7459277 |
Mammalian T1R3 sweet taste receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled...
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7455983 |
Medium for growing human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of mouse embryonic fibroblast feeder cells to...
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7452682 |
Identification of 5HT2A receptor ligands by selective amplification of cells transfected with receptors
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present...
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7452685 |
T1R1 receptor binding assays for identification of taste modulators
Binding assays for identifying components that modulate human T1R1 polypeptide-associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R1 polypeptide or...
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7452681 |
Diagnostic methods for the detection of autism spectrum disorder
The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of...
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7452727 |
Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit...
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7449303 |
Use of JAG2 expression in diagnosis of plasma cell disorders
The present invention is based on the finding that plasma cell disorders such as Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance are characterized by an increase in the...
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7449567 |
Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated...
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7445905 |
Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic...
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7445940 |
Method for diagnosing increased risk of preeclampsia
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-beta 3, receptors of cytokines of the TG beta...
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7445904 |
Cysteine string protein and its role in neurodegenerative diseases
The present invention relates to in vitro and in vivo assays for the identification of agents that are useful in the treatment of neurodegenerative diseases that are associated with defects in...
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7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
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7439030 |
Preparing membrane receptors from extracellular baculoviruses
The present invention describes a method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described...
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7439025 |
Antibodies binding a gamma carboxyglutamic acid displaying epitope
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while...
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7439039 |
Assays for novel serotonin transporter (SERT) blockers
The serotonin transporter (SERT) is a target of various therapeutic agents used in the treatment of neurological and neurodegenerative disorders. The present invention provides novel forms of SERT...
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7435552 |
Binding assays that use human T1R2 to identify potential taste modulators
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or...
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7431932 |
Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with...
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7431928 |
Identification of new CD8 epitopes from HIV-1 proteins
The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and...
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7429459 |
Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell
A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and...
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7429460 |
Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases
The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid...
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7427487 |
Constitutively active CXCR3 G protein-coupled chemokine receptor and modulators thereof for the treatment of inflammatory disorders
The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3...
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7427488 |
Purified and isolated platelet calcium channel nucleic acids and polypeptides and therapeutic and screening methods using same
Isolated and purified platelet voltage dependent calcium channel (VDCC) α 1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids,...
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7427489 |
Screening assay to identify modulators of the sleep/wake cycle
Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are...
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7427486 |
Mullerian inhibiting substance levels and ovarian response
Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively...
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7425445 |
Modulators that promote cell surface expression of odorant receptors
The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides...
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7425420 |
Identification of ligands by selective amplification of cells transfected with a 5HT2A receptor
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present...
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7422849 |
Method for determining expression of a PI3 kinase gene
This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways...
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7419779 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids”...
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7413867 |
Method for the identification of antagonists of a phenylthiocarbamide/bitter taste receptor
The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or...
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7413864 |
Treating cancer using a telomerase vaccine
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7407769 |
Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide
Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms,...
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7407761 |
Methods for assaying expression of novel galanin receptors
The present invention is directed to methods for assaying a test compound's ability to alter the expression of novel receptor for galanin which has been designated as galanin receptor 2. The...
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7407765 |
Human T2R receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine...
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7405051 |
Method of screening antiplatelet agents
A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2T AC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening...
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7405053 |
Materials and methods relating to G-protein coupled receptor oligomers
The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are...
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7402399 |
Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and...
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7402400 |
Mammalian sweet taste receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of...
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7402401 |
Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
In vitro methods of determining whether or not an individual has metastasized colorectal cancer cells are disclosed. In vitro methods of determining whether or not tumor cells are colorectal in...
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7399601 |
Human T2R61 taste receptor and related assays for identifying human bitter taste modulators
The claimed invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R61 that responds to particular bitter compounds The present invention further...
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7396651 |
Binding assay employing human T2R taste receptors
Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed...
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7396653 |
Cell migration assay
The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.
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7393654 |
Human T2R54 taste receptor and use for identifying bitter taste modulators
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R54 that responds to particular bitter compounds The present invention further...
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7393656 |
Methods and compositions for risk stratification
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
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7393647 |
Methods for detecting B. anthracis infection
This invention pertains to methods for detecting B. anthracis and antibodies to B. anthracis , the causative agent of anthrax, in a subject.
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7393655 |
Methods of identifying melanin concentrating hormone receptor antagonists
This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells...
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7393653 |
Methods of modulating cell death based on the Bit1/AES regulatory pathway
The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1...
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