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6936428 |
Dimeric flourescent polypeptides
The invention relates to proteins or polypeptides that comprise intramolecular dimers of fluorescent protein monomers. More specifically, the invention relates to recombinant polypeptides...
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6933108 |
Methods and compositions for use in the treatment of filovirus mediated disease conditions
Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least...
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6933107 |
Use of azetidinone compounds
The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or...
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6929922 |
Methods for the detection of demyelinating diseases
Methods are described for the use of transferrin binding as the basis for a diagnostic assay to identify pathologies consistent with demyelinating diseases including Multiple Sclerosis. In a...
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6924115 |
Process for identifying cell-specific target structures
This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on...
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6924116 |
Method for identifying cells
Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved...
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6916625 |
Artery- and vein-specific proteins and uses therefor
Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand,...
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6916608 |
Composition for providing long term stability to cells for diagnostic testing
The present invention relates to a method and composition for stabilizing clinical specimens (i.e., cells in biological samples) for transport and subsequent testing for diagnosis. The composition...
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6913892 |
Method of obtaining compositions comprising Y4 specific compounds
This invention provides an isolated nucleic acid molecule encoding a human Y4 receptor, an isolated protein which is a human Y4 receptor, vectors comprising an isolated nucleic acid molecule...
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6913894 |
Antibodies directed against signal regulator proteins
Monoclonal antibodies which bind specifically to the extracellular domain of the SIRP cell surface glycoproteins, and which, in some cases, block the interaction of SIRP with the surface molecule...
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6911316 |
Medical uses of scuPA/suPAR complex
Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a...
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6911313 |
Process for discriminating and counting erythroblasts
A method for discriminating and counting erythroblasts comprises the steps of: (i) staining leukocytes in a hematologic sample by adding a fluorescent labeled antibody capable of binding...
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6908742 |
Methods and kits for the detection of endotoxin
Methods for determining levels of endotoxin in a sample are provided. These methods are useful in the diagnosis of septicemia. Kits for the detection of endotoxin are also provided.
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6905815 |
Method of screening for inhibitors of VCP binding to polyglutamine, abeta, alpha-synuclein, and sod1
A method for screening substances which are useful as effective components of prophylactic or therapeutic drug for neurodegenerative diseases caused by the binding of an aberrant protein and a...
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6902902 |
Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other...
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6903195 |
Methods and compositions for detecting CDN apoptosis-modulating proteins
The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences and methods of use thereof are also provided.
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6900029 |
Method of selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation
A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have...
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6900021 |
Microfluidic system and methods of use
This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it...
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6897029 |
MCK-10 a novel receptor tyrosine kinase
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of...
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6897031 |
Multiparameter FACS assays to detect alterations in exocytosis
Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties...
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6893827 |
Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
Methods for detecting G-protein coupled receptor (GPCR) activity; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G-protein-coupled receptor kinase (GRK) activity, and...
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6890724 |
Methods and compositions for neural progenitor cells
The invention relates to methods and compositions for the isolation of neural progenitor cells.
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6884595 |
Immortalized human keratinocyte cell line
A spontaneously immortalized human keratinocyte cell line is disclosed. In a preferred embodiment, this cell line is ATCC 12191. In another embodiment of the invention, a method of assaying the...
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6884870 |
Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells
The invention provides a fusion protein including a reporter polypeptide, a linker polypeptide comprising a protease cleavage site, and a repressor polypeptide. The repressor polypeptide represses...
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6884770 |
Methods and compositions for treating or preventing peripheral neuropathies
The present application is directed to the discovery that hedgehog gene products are able to protect peripheral nerve cells under conditions which otherwise result in peripheral neuropathy. Certain...
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6884577 |
Methods for screening compounds for estrogenic activity
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
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6884591 |
Peripheral marker of blood brain barrier permeability
The present invention relates generally to a peripheral marker or marker of blood brain barrier integrity and methods of using them in the diagnosis, prognosis, and treatment of a variety of...
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6878811 |
Substance with antithrombotic activity and method for detecting glycokallidin
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a...
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6878521 |
Fibril-blocking peptide, a method for preventing fibril formation
A method of minimizing the aggregation tendencies of an amyloid forming protein is provided comprising identifying a portion of the protein that is critical to amyloid formation; and inserting a...
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6875576 |
Method for evaluating therapeutic efficacy
The present invention relates to in vitro methods for evaluating compounds that better correlate with therapeutic efficiency than evaluating compounds based on potency alone. In general, the...
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6875579 |
Device for binding molecules, molecular groups, molecular parts and/or cells
The present invention relates to a device for binding molecules, molecular groups, molecular parts and/or cells contained in a liquid to target structures, the device having at least one object...
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6875580 |
Antibodies specific for plasmacytoid dendritic cells
The invention provides immunological reagents (antibodies) capable of binding to plasmacytoid dendritic cells (pDC), to cell lines which express such antibodies and to a process for identifying and...
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6875578 |
System for cell-based screening
The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently...
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6875575 |
Diagnostic methods for neoplasia
This invention provides a method for diagnosing a patient with neoplasia.
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6872541 |
Method and compositions for analysis of pentraxin receptors as indicators of disease
A kit for assessing the level of pentraxin-binding moieties on particles in a biological sample containing a ligand comprising a pentraxin is useful in a method of assessing pentraxin-binding of...
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6869592 |
Method and antibody for imaging lung cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.
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6869770 |
Compositions and methods for early pregnancy diagnosis
Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the...
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6867009 |
Human capsaicin receptor and uses thereof
This invention provides novel human capsaicin receptors and the nucleotide sequences encoding these receptors. Also provided are vectors encoding these receptors and mammalian and non-mammalian...
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6863892 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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6864061 |
Method for screening compounds for anti-inflammatory activity
A method and cell line for screening test compounds for anti-inflammatory activity are disclosed. The cell line is a human cell line capable of producing a selected cytokine associated with an...
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6863880 |
Methods to diagnose a required regulation of trophoblast invasion
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β 3 , receptors of cytokines of the TGβ family,...
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6858399 |
Test for oxidative stress using cell suspensions
This invention provides a method of measuring oxidative response of cells without recourse to preparation of cell culture. The process involves:
1) preparing suspensions of cells from a...
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6855560 |
Method of identifying compounds that modulate human histamine H3 receptor
DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have...
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6855504 |
In vivo high throughput toxicology screening method
A high throughput toxicology screening method is provided. In the subject method, at least 10 different compound compositions are tested simultaneously. Each compound composition is tested by...
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6855495 |
Toso as a target for drug screening
The present invention is directed to methods for identifying novel compositions which modulate the activity of Toso, and the use of such compositions in diagnosis and treatment of disease.
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6852546 |
Diagnosis of autoimmune disease
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and...
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6849415 |
TRAF-3 deletion isoforms and uses thereof
The present invention provides an isolated TRAF-3 deletion isoform encoded by the nucleic acid sequence (SEQ ID NO:1) shown in FIG. 15 (deletion isoform Δ130 nucleid acid). One embodiment of the...
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6849416 |
Monoclonal antibody
A monoclonal antibody which is referred to as mAb 1E8, which was deposited at the DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, on Dec. 19, 2000 and which was...
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6849720 |
Monoclonal antibodies to the human LDL receptor, their production and use
There are provided monoclonal antibodies to the LDL receptor which are useful for the identification and purification of LDL and in treatment of e.g. hepatitis C infection.
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6846641 |
In vitro ischemia model
A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening...
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