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9091686 Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides  
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric...
9081011 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or...
9040245 Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm  
Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions...
9039994 Biomarkers for myocardial ischemia  
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial...
9040248 Kits for detecting and monitoring endocrine disrupting chemicals (EDCs)  
Described herein are compositions, a system, and kits for detection of endocrine disruptor chemicals (EDCs) in environmental samples, such as samples of water including but not limited to waste...
9040247 Detection of human T1R expressing cells  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
9034584 Metabolic maturation in stem cell-derived tissue cells  
The present invention concerns methods and compositions for promoting a conversion in stem cells or cells derived therefrom from glycolysis to aerobic respiration and its associated pathways,...
9034585 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
9034586 Method of detecting pancreatic disease and pancreas testing kit  
A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration...
9029321 Methods and compositions for targeting adipose cells in mammals  
Methods and compositions are presented for use in diagnostic, imaging or targeting of therapeutic agents to treat obesity/adiposity-associated disorders, where such as compositions and methods...
9023999 Anti-CD27 antibody  
The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or...
9023604 Method of reversibly staining a target cell  
The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the...
9017955 Fibrinogen assay  
The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in...
9018245 Method for promoting immune response comprising inhibiting CD22 function in B cells  
The purpose of the present invention is to elucidate a relationship between deregulation of signaling by CD22 and a rapid response of B cells by IgG-BCR and the like, and to provide a method...
9012161 Methods of identifying molecules that provide or enhance sweet taste  
The present invention provides methods for identifying a molecule that provides or enhances a sweet taste in the mouth and compositions containing such molecules. The methods involve determining...
9011862 Inhibitors of the nitration of amyloid β peptides and their uses in the diagnosis and treatment of Alzheimer's disease  
The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-β peptide (Aβ), comprising the steps of a) contacting at least one Aβ -peptide and/or the...
9012159 Cell based screening assays for the triglyceride synthesis pathway  
A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in...
9012643 Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same  
Hydroxamate substituted azaindoline cyanine dyes, conjugates thereof and methods of using the same are provided. The subject cyanine dyes include an azaindoline ring having a hydroxamate...
9012146 Method for selectively enriching and isolating microbial and optionally additional viral nucleic acids  
The present invention relates to a method for selectively enriching and/or isolating microbial and optionally additionally viral nucleic acids from samples that contain a mixture of microbial...
9011818 Materials and methods for biological imaging  
Water soluble InAs(ZnCdS) semiconductor nanocrystals with bright and stable emission in the near infrared (NIR) wavelength range have been prepared. The NIR semiconductor nanocrystals can be...
9012160 Monitoring skin metabolism products for evaluating burn injury  
The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as...
8999654 Method of identifying a compound for the treatment or prevention of obesity  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
8999655 Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders  
The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of...
8999652 Biological encoding of large numbers of cells  
Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be...
8993250 Methods and compositions for diagnosis and prognosis of renal injury and renal failure  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal...
8993244 Screening for compounds having immunosuppressant activity by testing impact on leukocyte-specific calcium fluxes  
The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca2+ flux in coronin 1...
8986935 Methods for treating spinal muscular atrophy  
Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of the compounds identified by the methods described herein to...
8981100 Use of novel coumarins as glutathione and thiol labels  
Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and...
8980638 Use of IMP3 as a prognostic marker for cancer  
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
8980177 Fluidic indicator device  
Disclosed is a fluidic assay device for assaying at least one property of a liquid sample, the device comprising: (i) a liquid sample application region;(ii) at least one test flow path in liquid...
8980567 Ex vivo method for determining potential GLP-2 receptor modulators  
Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of...
8975036 Methods for improved diagnosis of dysplasias  
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly...
8975384 Tag peptide and use thereof  
The present invention provides a tag peptide comprising an amino acid sequence represented by the following formula (I): X1-Tyr-X2-Gly-Gln-X3 (I) (wherein X1, X2 and X3 are the same or different...
8975035 Method of analyzing cells  
A method, optical apparatus and system for illuminating particles and for detecting emissions from illuminated particles in a flow cytometer. One configuration includes an objective lens coaxially...
8969018 Methods and compositions for monitoring and risk prediction in cardiorenal syndrome  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods...
8968994 Method for stem cell culture and cells derived therefrom  
There is described a method of promoting the attachment, survival and/or proliferation of a stem cell in culture, the method comprising culturing a stem cell on a positively-charged support...
8969016 Resonance energy transfer assay with cleavage sequence and spacer  
A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at...
8969017 Metabolite biomarkers for diagnosis and prognosis of pediatric septic shock  
The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome...
8962263 Methods and compositions for detecting the activation state of multiple proteins in single cells  
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
8962262 Method of protein extraction from cells  
Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least...
8962258 Apparatus and method for multiple immunoassays on a chip  
Provided are a multiple immunoassay apparatus on a chip in which a structure comprising multiple microfluidic channels is associated with a tissue sample, which allows immunohistochemical...
8956825 Intranuclear protein transduction through a nucleoside salvage pathway  
Provided herein are conjugate molecules containing a substrate for a nucleoside transport pathway linked to an active agent, wherein the conjugate can be transported into a cell or into the...
8951484 Circulating tumor cell capturing techniques and devices  
Candidate cells, such as circulating tumor cells (CTCs), present with blood are captured using a multiple stage device, having successive stages configured to deviate candidate cells out of the...
8951938 Combinatorial rosamine library to detect cell-state switching  
The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for...
8951745 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4...
8951744 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8945857 Methods of isolating cells and generating monoclonal antibodies  
The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of...
8945941 Tissue sample preparation and MALDI MS imaging thereof  
Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue...
8945847 Methods and kits for ascertaining biosafety of an agent  
A method of ascertaining the bio-safety of an agent is disclosed. The method comprises: (a) contacting the agent with differentiating human pluripotent stem cells;(b) analyzing a level of gene...
8945858 Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory  
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and...