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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7390489 |
Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody
The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes , a hybridoma cell producing the monoclonal antibody, a test kit comprising...
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7387880 |
Method for monitoring resting and activated platelets in unfixed blood samples
The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the...
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7384756 |
Methods for treating muscle diseases and disorders
The invention relates to methods of treating diseases and disorders of the muscle tissues in a vertebrate by the administration of compounds which bind the p185 erbB2 receptor. These compounds are...
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7384755 |
Cell-based assay for G-protein-coupled receptor-mediated activity employing a mutated cyclic nucleotide-gated ion channel and a membrane potential dye
Disclosed are compositions and methods for their use, such as in identifying G-protein-coupled receptors, ligands and compounds that modulate the activities of G-protein-coupled receptors. The...
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7384752 |
DNA encoding a human imidazoline receptor and ligand binding assay employing same
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the...
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7378252 |
Process for identifying modulators of G-protein-coupled receptors
The invention relates to a widely applicable process for identifying chemical compounds, which modulate G-protein-coupled receptors, by means of novel hybrid G-proteins with broad receptor...
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7378090 |
Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity
Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an...
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7374936 |
Method and means for site directed therapy
The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates...
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7374895 |
Guanosine triphosphate (GTP) binding protein-coupled receptor proteins that bind histamine and are expressed in the brain
A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA...
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7374890 |
Methods for identifying compounds that modulate ΔTRα2 activity
Truncated thyroid hormone receptors ΔTRα1 and ΔTRα2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering...
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7371562 |
Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7371541 |
G proteins, polynucleotide encoding the same and utilization thereof
We identified a novel protein (Gm1) comprising an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G...
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7371536 |
Methods for transporting vitamin C
The invention provides methods for regulating the transport of vitamin C across membranes.
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7371535 |
Processes for determining compounds that interact with snorf33 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors,...
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7371524 |
Substituted azaporphyrins as fluorescence labels
The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According...
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7368252 |
Agglutination accelerator for immunological measurement
An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known...
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7368249 |
Methods and compositions for evaluation and modulation of fertility
The present invention concerns compositions and methods for regulating or determining fertility in humans and animals. In various embodiments of the invention, LOX and other related enzymes can be...
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7364921 |
Method and apparatus for separating biological materials and other substances
A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands...
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7364867 |
Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells...
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7361478 |
High-throughput screen for identifying selective persistent sodium channels channel blockers
A method for identifying a selective persistent Na + channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na + current to a greater degree than a transient Na...
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7361477 |
Methods and compositions for inhibiting cellulolytic symbionts
Shipworms are important destroyers of wood in the marine environment. Wood users have long sought methods for preventing or limiting their attack. The invention is directed to compositions and...
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7361462 |
Method for efficiently determining a DNA strand break
The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors...
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7358058 |
Method and agents for the diagnosis and therapy of chronic inflammatory intestinal disease
Methods for diagnosis, early diagnosis, differential diagnosis, assessment of the severity and therapy-accompanying monitoring and prognosis of chronically inflammatory intestinal diseases (Crohn's...
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7358057 |
QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
The present invention relates e.g., to QM-7 or QT-6 cells comprising a heterologous mutant nicotinic α7 acetylcholine receptor and/or a nucleic acid encoding it, or a fragment or variant thereof....
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7358056 |
Methods for modulating signal transduction mediated by TGF-β and related proteins
Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-β) and members of the TGF-β family, such as bone morphogenic protein (BMP)....
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7355016 |
Methods for detection of mycobacteria
Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive...
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7354735 |
Nucleic acid encoding fluorescent protein constructs and methods for detecting apoptosis
Isolated nucleic acids encoding a fluorescent protein construct that detect apoptosis are disclosed. The isolated nucleic acids contain a donor-acceptor pair of green fluorescent proteins and a...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7354725 |
Kinase peptides and antibodies
The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and...
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7354722 |
Modulators of Smurf and BMP/TGFβ signaling pathways
This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases have been named Smurf1 and...
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7354614 |
Diagnostic device
A diagnostic device 1 for performing an immunochromatographic analysis of a sample is disclosed. The diagnostic device 1 comprises a porous substrate 10 for performing the analysis and a...
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7348161 |
Macrolide efflux genetic assembly
Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing...
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7348151 |
Method for the cellular high-throughput-detection of nuclear receptor ligand interactions
The invention relates to fusion proteins comprising at least three domains, where
a first domain facilitates membrane localization of the fusion protein in a cellular context, and a second...
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7344893 |
Immuno-gold lateral flow assay
A chromatographic lateral-flow assay system for rapid, high sensitivity method of detecting low levels of ligands in body fluids, with few false positives and few false negatives. The lateral-flow...
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7341859 |
ADH from Rhodococcus erythropolis
The present invention relates to an alcohol dehydrogenase from Rhodococcus erythropolis . By means of such cofactor-dependent ADHs, chiral alcohols, which can be of use for use in organic...
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7341842 |
TRP8, a transient receptor potential channel expressed in taste receptor cells
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells...
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7341841 |
Rapid microbial detection and antimicrobial susceptibility testing
A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and...
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7341840 |
Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
The present invention is directed to methods for the identification and uses of receptors that interact with anti-inflammatory compounds derived from eicosapentaenoic acid (EPA). The receptors are...
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7341836 |
Modified cyclic nucleotide gated ion channels
The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for...
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7338772 |
G-protein coupled receptor ligands and methods
The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for...
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7338771 |
Use of specific T2R taste receptors to identify compounds that block bitter taste
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to...
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7338769 |
Methods for identifying agonists of cypin
Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders.
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7335515 |
(1→3)-β-D-glucan binding domain protein, measuring method using the substance and assay kit
A (1→3)-β-D-glucan binding protein, a fluorescence-labeled (1→3)-β-D-glucan binding domain protein, a (1→3)-β-D-glucan measuring agent comprising the same, a method for measuring...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7335482 |
Method using neutral amino acid transporter expressing cell
A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a...
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7335481 |
Methods of identifying compounds that affect a fatty acid cell-surface receptor
The present invention provides methods for screening and identifying compounds that affect the metabolism of fatty acids and fatty acid derivatives, and thus for compounds that possess...
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