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7439029 |
Human 9q polypeptides method
The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated...
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7439023 |
Method of isolating a nucleic acid using a material containing an amino group and a carboxyl group and positively charged at a first pH and a solid material for nucleic acid isolation used for the method
Provided are a method of isolating a nucleic acid from a sample and a solid material for isolating the nucleic acid which can be used for the above method. The method includes contacting the sample...
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7439039 |
Assays for novel serotonin transporter (SERT) blockers
The serotonin transporter (SERT) is a target of various therapeutic agents used in the treatment of neurological and neurodegenerative disorders. The present invention provides novel forms of SERT...
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7435583 |
Membrane fractions of 1,2-sn-diacylglycerol-enriched cells
The invention concerns membrane fractions of cells containing a recombinant MGDG synthase and enriched with 1,2-sn-diacylglycerol, their preparation method, their use for screening molecules...
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7435419 |
Methods of diagnosing and treating pre-eclampsia or eclampsia
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia by detecting the levels of placental growth factor in a subject.
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7435550 |
Methods of using cytokine receptor zalpha11 to detect its ligands
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within...
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7435549 |
Method of identifying binding site domains that retain the capacity of binding to an epitope
The present invention relates to a method of identifying binding site domains that retain the capacity of binding to an epitope when positioned C-terminal of at least one further domain in a...
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7435552 |
Binding assays that use human T1R2 to identify potential taste modulators
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or...
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7435553 |
Isolating cells expressing secreted proteins
A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture...
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7432363 |
Ly6H gene
The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and...
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7431928 |
Identification of new CD8 epitopes from HIV-1 proteins
The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and...
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7432054 |
Method for separating and purifying a nucleic acid
An object of the present invention is to provide a method for separating and purifying a nucleic acid by adsorbing the nucleic acid in a test sample to a surface of a solid phase and desorbing the...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7429492 |
Multiwell plates with integrated biosensors and membranes
The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane.
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7429449 |
Potassium channel mutants of the yeast Saccharomyces cerevisiae and their use for screening eukaryotic potassium channels
The invention relates to processes for identifying inhibitors and activators of eukaryotic potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous potassium channels...
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7429389 |
Vaccines for Mycoplasma bovis and methods of use
The invention of novel, effective vaccines against Mycoplasma bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related...
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7427487 |
Constitutively active CXCR3 G protein-coupled chemokine receptor and modulators thereof for the treatment of inflammatory disorders
The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3...
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7427488 |
Purified and isolated platelet calcium channel nucleic acids and polypeptides and therapeutic and screening methods using same
Isolated and purified platelet voltage dependent calcium channel (VDCC) α 1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids,...
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7425622 |
Antibodies against C3a receptor
The present invention relates to antibodies and related molecules that specifically bind to C3a Receptor. Such antibodies have uses, for example, in the prevention and treatment of asthma, allergy,...
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7425420 |
Identification of ligands by selective amplification of cells transfected with a 5HT2A receptor
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present...
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7425421 |
Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody...
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7423130 |
PRO1158 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7422861 |
Oligonucleotide transfection screening method
Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can...
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7422846 |
Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
The present invention is related to a method of detecting the dysregulation of GPR86 activity.
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7419793 |
Flea octopamine receptor nucleic acid molecules, proteins and uses thereof
The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such...
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7419791 |
Methods of screening compounds using a T1R3 hetero-oligomeric taste receptor
Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding...
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7419790 |
Sodium-independent transporter carrying acidic amino acid and its gene
It is intended to provide a sodium-independent transporter carrying an acidic amino acid and its gene. A protein having the amino acid sequence represented by SEQ ID NO: 1 and being capable of...
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7419779 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids”...
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7419806 |
Immunogenic Mycoplasma hyopneumoniae polypeptides
Mycoplasma hyopneumoniae polypeptides and nucleic acids, as well as nucleic acid expression vectors and host cells containing nucleic acid vectors are provided. In addition, compositions...
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7419776 |
Method of reducing pathogen load
An improved therapy is described for patients suffering from pathological conditions characterized by viral, fungal, bacterial, or protozoal load by which such load is reduced. The invention also...
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7419657 |
Treatment of atherosclerotic disorders
The present invention relates to the identification of lipid oxidizing abzymes as a key pathogenic factor in atherosclerotic disorders. Methods and means for the reduction of abzyme mediated lipid...
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7413867 |
Method for the identification of antagonists of a phenylthiocarbamide/bitter taste receptor
The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or...
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7413864 |
Treating cancer using a telomerase vaccine
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7407767 |
Method of screening remedy for heart disease and medicinal composition for treating heart disease
A method for screening a substance that inhibits the onset of anti-cardiac troponin I autoantibody-related disease, a pharmaceutical composition and a base material for therapy of cardiac disease...
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7407769 |
Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide
Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms,...
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7407761 |
Methods for assaying expression of novel galanin receptors
The present invention is directed to methods for assaying a test compound's ability to alter the expression of novel receptor for galanin which has been designated as galanin receptor 2. The...
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7407768 |
Membrane-based assays
Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct...
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7407765 |
Human T2R receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine...
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7407659 |
Methods of diagnosing pre-eclampsia or eclampsia
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels...
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7407743 |
Kit and method of screening wilson's disease
The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard...
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7407796 |
Interrogation of changes in the contents of a sealed container
A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet...
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7407766 |
Screening method for agonists or antagonists of semaphorin 6C by determining the effect of a test compound on the interaction between semaphorin 6C and plexin-A1
The present invention provides screening methods for agonists or antagonists of Sema6C using Plexin-A1, and tools for the screening and the like. It evaluates a case of making a recombinant protein...
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7407764 |
Plasma C5A levels as an indicator of asthma severity
This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient...
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7405042 |
Method of extracting nucleic acid or protein using dendrimers and dendrimer-compositional substances
The present invention relates to a method of extracting nucleic acid or protein, in which multi-layer dendrimers are formed on the surface of fine particles, amino radicals for capturing nucleic...
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7405051 |
Method of screening antiplatelet agents
A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2T AC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening...
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7405052 |
Voltage sensor domains of voltage-dependent ion channel proteins and uses thereof
A composition of matter suitable for use in identifying chemical compounds that bind to voltage-dependent ion channel proteins, the composition comprising a screening protein that comprises an ion...
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7405053 |
Materials and methods relating to G-protein coupled receptor oligomers
The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are...
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7402399 |
Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and...
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