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7541155 |
Methods of screening compositions for potential insect control activity
The present invention comprises compositions, methods and cell lines related to controlling insects. An embodiment of a composition comprises a plant essential oil and targets at least one receptor...
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7541156 |
Method of identifying antinociceptive compounds using protease activated receptor-2
The invention provides a method of decreasing pain in a subject, the method comprising administering to the subject an amount of a compound effective to decrease activation of protease activated...
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7541196 |
Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including early detection of cancers
An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group...
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7537903 |
FGF21 upregulates expression of GLUT-1 in a βklotho-dependent manner
A method is provided to identify a modulator of βKlotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of βKlotho and an FGFR.
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7537924 |
Virus strains
The present invention relates to clinical herpes simplex virus (HSV) isolates with improved oncolytic capabilities as compared to reference laboratory HSV strains. The present invention also...
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7537938 |
Biomarker detection in circulating cells
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7534580 |
PSP94 diagnostic reagents and assays
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
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7534579 |
14273 receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
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7534573 |
Method of identifying therapeutic agents for the treatment of epilepsy
The present invention relates to a method of identifying agents suitable for use in treating epilepsy and other brain disorders, including but not limited to bipolar disorder, schizophrenia and...
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7534576 |
Method and a device for the evaluation of biopolymer fitness
A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules...
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7534577 |
Functional assays that use the T1R2 taste receptor to identify potential taste modulators
Functional assays that use hT1R2 receptor polypeptides to screen for taste modulatory compounds are provided. In preferred embodiments these assays will use cells that stably or transiently express...
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7534574 |
Epitope-captured antibody display
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is...
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7531304 |
Method for screening FGFR-4 agonists
The present invention relates to the use of Fibroblast-Growth Factor Receptor (FGFR) agonists for the diagnosis, prevention and/or treatment of pathological conditions including, but not limited to...
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7531163 |
Enrichment methods for the detection of pathogens and other microbes
The present invention provides novel enrichment, testing and detection methods for detection of pathogens or other microbes in a food, water, wastewater, industrial, pharmaceutical, botanical,...
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7531312 |
Simplified biological evaluation method of natural and artificial chemicals by using DNA injury index and apparatus therefor
A biological evaluation method for rational and simply evaluating biological harmfulness or usefulness of a great number of natural and artificial chemicals, foods, etc. This method comprises...
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7531315 |
Method for detecting a host receptor for pathogenic bacteria
A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli ....
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7528093 |
SCN3A locus for idiopathic generalized epilepsy, mutations thereof and method using same
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome...
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7527937 |
Assay employing a g-protein coupled receptor that is activated by CCK-8S
Methods of providing a protein having a function as a G-protein coupled receptor and methods of identifying a compound that inhibits or promotes a function of the protein and/or expression of a DNA...
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7527934 |
Labeled substrate conjugates for identifying enzyme inhibitors
This invention provides labeled-substrate conjugates for assaying enzymes, particularly neuraminidases. Also provided are assays that are useful for identifying compounds that inhibit...
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7527935 |
G-protein coupled receptor having eicosanoid as ligand and gene thereof
The present invention provides a polypeptide selected from the following (A), (B) and (C), having a function or an activity as a receptor of an eicosanoid (5-oxo-ETE, etc.);
(A) a...
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7524637 |
Functional assays that use the T1R1 receptor to screen for T1R1-associated taste modulators
Functional assays that use the T1R1 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput compound assays to identify compounds...
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7524625 |
Real time binding analysis of antigens on a biosensor surface
The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors.
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7524936 |
Mitogenic oxygenase regulators
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
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7524941 |
Methods for the preparation of chemically misaminoacylated tRNA via protective groups
The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates...
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7521194 |
Method for detection of MIP-4 and CCRL2 binding and activity modulating agents
A method of detecting an agent that modulates the activity of CCRL2, the method comprising: (a) contacting a CCRL2 polypeptide with a macrophage inflammatory protein-4 (MIP-4) polypeptide in the...
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7517659 |
Potassium channel molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides...
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7517660 |
Optoelectronic sensor
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where...
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7517849 |
Inhibition of ABC transporters by transmembrane domain analogs
ATP-binding cassette (ABC) transporters generally contain a number of transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides...
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7517658 |
Methods for preparing compositions using a SNORF33 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors,...
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7514267 |
Detection systems utilizing supported lipid bilayers
The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.
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7514227 |
Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnostic kit for cardiac disease
The present invention relates to an immunological formulation and a diagnostic kit for cardiac disease using human mitochondrial adenylate kinase isozymes. The present invention provides an...
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7514226 |
Antibody pair screening methods
The invention provides methods for identifying antibody preparations that can form a pair of antibodies that optimally detect a target antigen, for example, in a sandwich immunoassay. These methods...
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7514223 |
Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
The invention is directed to a cross-screening system and methods of the invention utilizing a combination of an immunoassay (IA) and electrochemiluminescence assay (ECLA) to identify molecules...
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7511064 |
Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament...
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7510847 |
Kidney-specific urate transporter and gene thereof
It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene....
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7510846 |
Assay employing human or rat GAL-R2 galanin receptor
The present invention is directed to a novel receptor for galanin which has been designated as galanin receptor 2. The invention encompasses both the receptor protein as well as nucleic acids...
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7510845 |
Assay employing G protein-coupled receptor expressed in dorsal root ganglia
The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a...
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7507544 |
Functional assays that use the T1R3 receptor to screen for taste modulatory compounds
Functional assays that use the T1R3 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput functional assays that identify...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7507547 |
Screening assays for antioxidants and antiproliferative compounds
Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities.
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7507545 |
Ion channel modulating activity method
Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early...
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7507528 |
Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells
This invention relates to a method for selecting and/or for qualitative and/or quantitative detection of predetermined biological cells from or in a sample containing biological cells, the sample...
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7507543 |
GABAB receptor polypeptides and screening methods
The present invention relates to a nucleic acid molecule encoding a human or canine GABA B receptor, or a conservative variant thereof.
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7507542 |
Method for regulating immune function using the FOXP3 protein
Isolated nucleic acid molecules are provided which encode Fkh sf , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and...
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7504226 |
Methods relating to treatment of atherosclerosis
The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. These disorders may be treated by inhibiting this antibody...
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7504227 |
Drug targets for the treatment of neurodegenerative disorders
Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7501232 |
Method for cell selection
The invention relates to a method for the non-invasive selection of single living cells under gentle conditions from mixtures of cells or cell cultures with respect to a specific production...
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7497997 |
Assay cartridges and methods of using the same
Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber...
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