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7074575 |
Use of interleukin-19 to treat ovarian cancer
The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes...
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7070760 |
Skin test for schizophrenia
A diagnostic method for assaying schizophrenia in a subject is provided wherein a preparation comprising platelet derived proteins or fractions thereof having a pI above about 6.5 is injected into...
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7071006 |
Carrier holding micro-substances, system suspending such carriers apparatus for manipulating such carriers and method of controlling positions of such carriers
Carriers hold remote-acting bodies which can be manipulated by a remote force, and also hold a micro-substance which is a target substance of an assay. The remote-acting bodies are manipulated in...
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7071005 |
Method and device for concentrating selected groups of microorganisms
A method and device are described to concentrate target organisms from a mixture of organisms. Beads ( 1 ) made of material such as nylon, polystyrene or glass are coated with antibodies of...
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7070944 |
System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a...
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7070943 |
Detection of protein conformations in single cells
Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7067260 |
Methods of identifying morphogen receptor-binding analogs
Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7067324 |
Photon reducing agents for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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7067263 |
High throughput screening assay systems in microscale fluidic devices
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are...
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7067262 |
Cell line for the expression of an α2δ2 calcium channel subunit and methods of use
Described is a method for determining the binding ability of a compound to bind to an α2δ2 subunit of a calcium channel comprising: providing an α2δ2 subunit of a calcium channel, contacting...
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7067322 |
Fusion protein arrays on metal substrates for surface plasmon resonance imaging
Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are...
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7067321 |
Polyglutamine repeat sequences
Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study...
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7063954 |
Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
Screening methods for identifying compounds that bind to or activate corticotropin releasing factor 2 receptors (CRF 2 R) and regulate or potentially regulate skeletal muscle mass or function in...
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7060448 |
Evaluating binding affinities by force stratification and force panning
The present invention is a method for selectively removing objects from a surface utilizing a probe. The probe is scanned over the surface utilizing a greater and greater relative amount of force...
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7060449 |
Method of preparing GALR2 receptors composition
This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin...
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7060447 |
Protein localization assays for toxicity and antidotes thereto
Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. The profile of...
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7060450 |
Screening assays for agonists and antagonists of the hedgehog signaling pathway
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning...
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7060801 |
Antibodies to human growth factor huXAG-3 and methods of use
The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1,...
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7056677 |
Soluble mast cell function associated antigen (MAFA) pharmaceutical compositions and methods of making and using them
This invention provides pharmaceutical compositions and methods for controlling and modifying Natural Killer (NK) cell and T cell functions by manipulation of “mast cell function-associated...
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7056657 |
Apparatus and methods for magnetic separation
Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface,...
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7056746 |
Array cytometry
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7056665 |
Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
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7056689 |
Methods of treating and detecting cancer using viruses
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The...
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7056687 |
Methods and compositions for screening for altered cellular phenotypes
The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more...
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7056688 |
LDL receptor signaling assays
The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction...
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7056510 |
Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules...
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7056680 |
Antibodies to claudin-50 polypeptide
The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of...
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7052833 |
Absorptive hypercalciuria locus on human chromosome 1
Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in...
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7052849 |
Protein biopolymer markers predictive of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7052858 |
Diagnostic assays for detection of Cryptosporidium parvum
This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and...
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7049072 |
Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
Pluri-differentiated human mesenchymal progenitor cells (MPCs) are isolated. A method isolates and purifies human mesenchymal progenitor cells from Dexter-type cultures for characterization of and...
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7049150 |
Binding assay device with non-absorbent carrier material
A binding assay device includes a porous membrane comprising a material enabling capillary movement of a liquid sample from a first area on the membrane on a second area on the membrane. A...
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7049064 |
Method for obtaining a surface activation of a solid support for building biochip microarrays
The present invention is related to a method for making microarrays comprising the steps of:
submitting the surface of a solid support to an oxidation of chemical groups present on said surface in...
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7049076 |
Method for assaying protein—protein interaction
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the...
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7049083 |
Methods for identifying modulators of N-type ion channel inactivation
Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal...
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7045298 |
Method for identifying or screening agonist and antagonist to PPAR
A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to...
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7045342 |
Diagnostic detection device and method
The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a...
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7045304 |
Cells for drug discovery
Disclosed herein are compositions and method useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process.
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7045294 |
Promoter sequences
The present invention relates an isolated human Site-1 Protease promoter region. The invention also relates to screening methods for agents decreasing the expression of Site-1 protease and thereby...
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7045303 |
Screening methods for compounds useful in the treatment of polycystic kidney disease
The present invention provides cell-based screening assays designed to identify agents that regulate the activity of the polycystic kidney disease proteins encoded by the PKD-1 and PKD-2 genes and...
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7045283 |
Methods of high-throughput screening for internalizing antibodies
This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand;...
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7041461 |
Methods of identifying agonists and antagonists of mammalian NPFF receptor
This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells...
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7041463 |
Orthologues of human receptors and methods of use
Methods for identifying modulators of receptor activity using orthologues of human receptors are described. Additionally, a method for identifying an animal model useful in the screening of...
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7041464 |
Method for determining a gushing factor for a beverage
The invention relates to a method for determining a gushing factor for a beverage, in which method the quantity of hydrophobin is determined from the raw material of the beverage and/or from the...
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7041462 |
Conformational and topological protein regulation
Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a...
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7037665 |
Compositions comprising SNORF36 receptor compounds
This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors,...
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7037662 |
Receptor-ligand system and assay
An Eph family RTK (receptor tyrosine kinase) ligand-binding domain as well as a method of identifying Eph family RTK agonists or antagonist. The ligand-binding domain is suitably encoded by exon...
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7033768 |
Reverse two-hybrid systems
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ...
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