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7150971 |
Membrane-resident steroid receptors and methods of use thereof
This invention pertains to the discovery that DPR-1 encodes a putative nuclear hormone receptor (NHR) that, based on gene reporter studies, is expressed in the endoderm throughout the life of the...
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7150966 |
Assay methods and systems
Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second...
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7148028 |
Methods and means relating to atherosclerosis
The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for...
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7148027 |
Method of assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters
A method of measuring the individual response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters involves in vitro monitoring of radiolabeled monoamine...
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7148017 |
High sensitivity mechanical resonant sensor
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an...
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7148022 |
Assay for anti-viral agent
There is provided an assay for selecting an anti-viral agent effective against picornavirus infection. The assay selects an agent which disrupts the association between picornavirus protein 2C and...
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7148026 |
Dog melanin-concentrating hormone receptor
The present invention features polypeptides and nucleic acids related to a dog MCH receptor and uses of such polypeptides and nucleic acids. The dog MCH receptor is a G protein coupled receptor...
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7144710 |
Method for detecting inflammation and inflammatory conditions
Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in...
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7144696 |
Use of azetidinone compounds
The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or...
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7144704 |
Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a...
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7144996 |
Nucleic acid encoding human suppressor of fused
The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those...
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7141436 |
Immunoassay and reagents and kits for performing the same
A sandwich immunoassay is disclosed that provides simple to perform yet sensitive identification of analytes in samples. All assay constituents needed (except analyte to be detected) for one assay...
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7141384 |
Detection of pleiotrophin
The invention relates to a novel method and kit for detecting and measuring pleiotrophin in samples and diagnosing pleiotrophin-positive diseases. The method involves incubating a sample suspected...
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7141383 |
EDG8 receptor, its preparation and use
The present invention relates to newly identified human EDG8 receptors, polynucleotides encoding this receptor, polypeptides encoded by such polynucleotides, the preparation and the use of such...
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7141387 |
Microorganism culture medium
A microorganism culture medium comprising a derivative A′ of a chromogen A, and a chromogen B, where the chromogen A is a chromogen being oxidized to a colorant, and the chromogen B is a...
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7141366 |
Surface display of selenocysteine-containing peptides
The naturally-occurring amino acid selenocysteine (SEC) is incorporated uniquely and specifically in the context of a polypeptide displayed on the surface of an amplifiable genetic particle (phage,...
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7138238 |
Ligand sensor devices and uses thereof
Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of...
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7138248 |
Method of inhibiting inward rectifier, G-protein activated, mammalian, potassium channels and uses thereof
Compositions and methods are provided for producing functional mammalian inward rectifier, G-protein activated potassium channels (Kir3.0 channels). A channel is a multimeric protein comprising one...
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7138246 |
Methods for identifying or screening for agents that modulate 17β-HSD3
Methods for determining whether a test agent inhibits a 17β-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17β-HSD3; obtaining a reaction mixture comprising...
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7138237 |
Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA...
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7135297 |
Protein biopolymer markers indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7135340 |
Tetrameric antibody complexes for blocking non-specific labeling of antigens
A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody...
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7135300 |
Profiling frequencies of receptor heterodimers
Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which...
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7135176 |
VMP-like sequences of pathogenic Borrelia
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia , the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded...
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7135299 |
Catalase-inactivating compounds and the use thereof
The invention relates to the sulfonyl esters of the general formula R 1 —COO—SO 2 —Z—R 2 , wherein Z, R 1 and R 2 are defined as in claim 1 . The invention further relates to the use of...
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7135298 |
Screening assay for agents that alter target of Rapamycin activity
The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate...
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7132243 |
Clonal expansion of T cells of unknown specificity and identification of ligand recognized by the clonally expanded T cells
A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided. A process for clonally expanding T cells of...
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7132248 |
Uses of galanin GALR2 receptors
This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin...
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7132247 |
Composite devices incorporating biological material and methods
The present invention provides composite biological devices that include biological material as an integral component thereof. The devices can be used for measuring metals, for example,...
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7132245 |
Organ transplant rejection and associated conditions
The application discloses markers associated with organ transplant rejection and associated conditions, and in particular provides materials and methods for the diagnosis, prognosis or treatment of...
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7132244 |
Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7129055 |
Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was...
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7129096 |
Sensor for use in testing biological, biochemical, chemical or environmental samples
Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same.
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7129053 |
Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool
The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism comprising the following steps: (a) provision of an immunochromatographic test with a...
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7129056 |
Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular...
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7125659 |
Method and screening candidate compounds for drug against tumor
Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in...
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7125679 |
Methods to screen peptide libraries using minicell display
A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process....
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7125972 |
Solid carriers with peptide nucleic acid probes and methods for regeneration
A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence...
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7125678 |
Protein biopolymer markers predictive of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7125680 |
Methods and materials for characterizing and modulating interaction between heregulin and HER3
The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include methods...
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7122327 |
Biopolymer markers indicative of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7122325 |
Method of modulating tetrotodoxin-resistant sodium channel
The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA...
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7122326 |
Identification of modulators of neurotransmitter activity of xanthurenic acid
The invention relates to methods and compositions for the selection and development of novel pharmacological agents or novel medicaments having properties or mechanisms of action which are...
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7122330 |
High-throughput screening of expressed DNA libraries in filamentous fungi
The invention provides a method for the expression of exogenous DNA libraries in filamentous fungi. The fungi are capable of processing intron-containing eukaryotic genes, and also can carry out...
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7122320 |
Method for detecting acid-resistant microorganisms in the stool
The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different...
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7118873 |
Polynucleotides encoding cellular transporters and methods of use thereof
This disclosure encompasses the Indy gene, polypeptides encoded by the Indy gene and fragments thereof. This disclosure also encompasses homologs of the Indy gene both from Drosophila and other...
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7118866 |
Heterodimeric receptor libraries using phagemids
Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor...
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7118862 |
Induction of apoptosis by cellular stress
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such...
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7115377 |
Cell-based assays for G-protein-coupled receptor-mediated activities
Disclosed are compositions and methods for their use, such as in identifying G-protein-coupled receptors, ligands and compounds that modulate the activities of G-protein-coupled receptors. The...
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7115229 |
Apparatus and method for monitoring molecular species within a medium
Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing....
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