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8183001 |
Methods and compositions related to GABA receptor subunits
Disclosed are compositions and methods related to GABAA receptors.
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8182999 |
Compositions and methods for early pregnancy diagnosis
Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the...
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8182998 |
Blood biomarkers for bone fracture and cartilage injury
Blood biomarkers are described for use in methods and compositions to determine whether an individual has sustained a bone fracture or a cartilage injury.
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8182746 |
Electrophoresis process using a valve system
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises...
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8178304 |
Diagnostic methods relating to Graves' disease and other autoimmune disorders
The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of...
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8178308 |
Use of IL-27 agonists to increase interferon-gamma production
Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
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8178058 |
High throughput cell-based assays, methods of use and kits
In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation....
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8178305 |
Method of analyzing biochemical
A method of highly sensitive and quantitative luminescent analysis with the use of a detection device using a micro-channel and carrying a molecule which is capable of capturing a substance to be...
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8173372 |
Methods of donor specific crossmatching
The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating Tie-2+ and CD34− precursor endothelial c...
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8173377 |
Methods and compositions for determining the purity of chemically synthesized nucleic acids
This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which...
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8173378 |
Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO:...
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8173373 |
Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling
Methods for screening compounds that modulate umami taste signaling in taste cells are provided. These methods comprise contacting a compound with hetero-oligomeric taste transduction G-protein...
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8173125 |
Wise/Sost nucleic acid sequences and amino acid sequences
The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The...
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8168403 |
Agonists of bitter taste receptors and uses thereof
The present invention relates to agonists of the human bitter-taste receptor hTAS2R40 and their role in bitter taste transduction. The invention also relates to assays for screening molecules that...
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8168401 |
Methods of detecting T1R2- and T1R3-expressing cells potentially sensitive to sweet tastants
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
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8168395 |
Taste receptors of the T1R family from domestic dog
The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence...
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8168392 |
Tetrahydrofolate synthetase gene
By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is...
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8168397 |
Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody
The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of...
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8163496 |
Methods and kits for measuring von Willebrand factor
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having ...
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8163562 |
Photon reducing agents for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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8163504 |
Combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event
A method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, includes: measuring, in a sample obtained from the subject, at...
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8163877 |
Ligand gated ion channels from Dermacentor variabilis
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates...
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8165517 |
Methods for identifying inhibitors of vascular injury
The present invention provides, inter alia, inhibitors of cardiovascular diseases and disorders. The present invention also provides therapeutic methods for preventing and/or treating...
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8163503 |
Methods of identifying compounds that bind TANGO509
The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and...
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8163498 |
Method for determination of molecular weight of hyaluronic acid
A method of measuring a molecular weight of hyaluronic acid, comprising at least reacting hyaluronic acid in a sample containing the hyaluronic acid with a hyaluronic acid-binding protein to...
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8163505 |
Methods using PBK1 for identifying agents that treat metabolic disorders
The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a...
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8163507 |
Process for the determination of inflammatory processes and pharmaceutical compositions for the treatment thereof
A method for analyzing extracellular body fluids as to the presence of the Y-box protein YB-1 and fragments thereof, which are secreted by the cell, in order to determine inflammatory processes and...
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8158405 |
Process for concentrating and processing fluid samples
A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological...
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8158372 |
Agonists of a bitter taste receptor and uses thereof
The present invention relates to agonists of the hTAS2R14 bitter taste receptor and its role in bitter taste transduction. The invention also relates to assays for screening molecules that...
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8158370 |
Anaplasma phagocytophilum (Aph) antigens and antibodies specific for Anaplasma
The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.
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8158442 |
Antagonists of bitter taste receptors and uses thereof
The present invention relates to antagonists of the human bitter-taste receptors hTAS2R38. The invention also relates to methods for identifying further molecules that suppress hTAS2R38 mediated...
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8153383 |
Mycobacterial culture screening test for Mycobacterium avium complex bacteria
A method of antigen-capture assays that uses the detection of antigens secreted into liquid culture is provided. Also provided are antibodies to Mycobacterium avium complex-specific antigens, and...
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8153385 |
Target protein and target gene in drug designing and screening method
The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the...
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8153386 |
Human T2R64 taste receptor and related assays for identifying human bitter taste modulators
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R64 that responds to particular bitter compounds The present invention further...
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8149410 |
Detecting device, detecting unit substrate, detecting unit, detecting unit kit and detecting method
A necessary number of metal structures including a trapping body for trapping a target substance provided on a support are one-dimensionally placed to form a transmission path of plasmon, and a...
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8148093 |
Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk
This invention relates to a method for assessing risk of prostate cancer. Specifically, it relates to utilizing both Pro108 and Prostate Specific Antigen (PSA) in combination to determine the risk...
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8148171 |
Multiplexed analysis of clinical specimens apparatus and methods
A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset,...
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8142762 |
Methods of using GPR101 receptors to identify modulators of hypothalamic proopiomelanocortin (POMC)-derived biologically active peptide secretion
The present invention relates to methods of using GPR101 G protein-coupled receptor (GPCR) to screen candidate compounds as modulators of hypothalamic proopiomelanocortin (POMC)-derived...
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8137922 |
Method for diagnosing the metabolic syndrome (MS)
The present invention discloses a method for diagnosing the metabolic syndrome by determination of the afamin content in a sample of a body fluid or a tissue sample, wherein the metabolic syndrome...
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8133689 |
Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
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8128890 |
Methods and algorithms for cell enumeration in a low-cost cytometer
The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in...
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8129159 |
Attachment of molecules to surfaces
The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present...
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8129111 |
Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same
The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric...
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8129106 |
Sequence-specific detection of methylation in biomolecules
A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a...
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8128930 |
Anti-ADDL antibodies and uses thereof
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can ...
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8129130 |
High affinity antibodies against HMGB1 and methods of use thereof
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
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8124349 |
Toll-like receptor assays
Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR...
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8124356 |
Methods of purifying zsig33
The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility,...
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8124361 |
Methods of screening for sweet taste modulators
We have discovered a method to enhance sweetness comprising the use of a sweetener at a sub- to near-threshold concentration which is used in combination with a suprathreshold concentration of...
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8124360 |
Use of a T1R2 nucleic acid sequence to identify tastants
Provided are functional methods using the T1R2 monomer of the T1R2/T1R3 sweet receptor to identify agonists and modulators of the sweet taste response.
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