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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7611844 |
Methods for detecting asymmetric dimethylarginine in a biological sample
The present invention provides methods of detecting asymmetric dimethylarginine (ADMA) in a sample, particularly a sample that may contain symmetrical dimethylarginine (SDMA) and/or arginine. The...
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7608407 |
Fluorescence polarization assay for determining histidine decarboxylase activity
The present invention relates to fluorescence polarization assays for determining the HDC modulating activity of a candidate compound including providing a reaction mixture comprising a HDC,...
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7608410 |
Method of improving T cell receptors
A method of increasing the affinity and/or decreasing the off-rate of a given TCR specific for a given target pMHC, comprising creating a plurality of TCRs having an α chain CDR2 sequence and/or a...
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7608416 |
Targeting mPGES-1 as a treatment for inflammation which avoids cardiovascular risk
The present invention relates to methods for the treatment of inflammation and pain without increasing cardiovascular risk by administration of an inhibitor of mPGES-1. The invention further is...
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7608465 |
Multi-analyte diagnostic test for thyroid disorders
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and...
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7608414 |
Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease
Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample.
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7608393 |
Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of...
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7608412 |
P62 as a diagnostic tool for alzheimer's disease
The p62 protein has been analyzed and identified as the significant contributor to several metabolic pathways that lead to metabolic syndrome, Alzheimer's Disease, and other related diseases. The...
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7608409 |
Screening assay using G-protein coupled receptor protein OT7T175
The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof,...
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7608406 |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and...
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7608395 |
Systemic lupus erythematosus diagnostic assay
The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608246 |
Apolipoprotein E as an adjuvant for lipid antigens
The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the...
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7608411 |
Prostaglandin receptor EP1
(1) A novel polypeptide prostaglandin E receptor, (2) a cDNA encoding the polypeptide and a fragment selectively hybridized to the sequence of the cDNA, (3) a replication or expression vector...
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7608404 |
Disease determination method, data generation method for disease determination and data generation system for disease determination
Supernatant of the urinary sample (SP 1 ) was mixed with an acid or alkali and heated (SP 2 ) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP 3 )....
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7608408 |
Methods of identifying compounds that inhibit Notch cleavage
In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying γ-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are...
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7608405 |
Method of selectively assaying adiponectin multimers
Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of...
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7608403 |
Method for cancer detection, progression analysis and malign tumour prognosis based on the study of metabolic markers of the cell
Described is a method for cancer detection, progression analysis and malign tumor prognosis based on the study of metabolic markers of the cell. The method consists in using the study of the...
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7604935 |
Soluble rubella E1 envelope protein variants
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the...
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7604953 |
Bioamplification for microbial sensor signal transduction
A process of detection of the causative agent of Johne's disease ( Mycobacterium avium subsp. paratuberculosis ) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of...
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7604950 |
Methods for early detection of pregnancy in cows
Disclosed are methods for determining the pregnancy status of a cow by detecting a pregnancy-associated glycoprotein (PAG) level that comprises proteins present in an acidic protein fraction of day...
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7604946 |
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in...
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7604957 |
Method for diagnosing immunologic food sensitivity
A method for food sensitivity panel testing (for sensitivities other than gluten sensitivity) by detecting IgA antibodies in serum is disclosed. A method for testing stool samples for the presence...
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7604948 |
Biomarkers for diagnosing an autism spectrum disorder
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using...
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7604947 |
Detection and modulation of cancer stem cells
The invention relates to method for detecting and modulating the expression and activity of REX-1. As described herein, REX-1 is expressed in certain cancer cells, including cancer stem cells. The...
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7604959 |
Cell-based assays employing voltage and calcium dyes
Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in...
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7605004 |
Test strip for a lateral flow assay for a sample containing whole cells
A test strip for conducting a lateral flow assay for detection of an analyte in a sample that contains cells and fluid is provided, as well as methods for making and using the test strip. This test...
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7604951 |
Method for identifying compounds that modulate RXR associated processes with IgE production
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7604952 |
Detection and determination of the stages of coronary artery disease
A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing...
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7604939 |
Methods of identifying active BRM expression-promoting HDAC inhibitors
The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a...
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7604949 |
Methods and compositions that affect melanogenesis
The invention provides methods of screening for compounds that affect melanogenesis and the function of P protein in organisms, cells, or cell-free systems. The invention further relates to...
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7604981 |
Excitable target marker detection
A variety of types of molecules are detected and/or analyzed using an integrated micro-circuit arrangement. According to an example embodiment of the present invention, a micro-circuit arrangement...
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7605003 |
Use of biomarkers for detecting ovarian cancer
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the...
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7604954 |
Method for evaluating kidney function in a feline
Methods for ( 1 ) evaluating feline kidney function by determining ghrelin level in feline tissue or biofluid and correlating the ghrelin level directly to kidney function and ( 2 ) diagnosing...
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7601542 |
Analytical method for protein mapping using hydrogen/deuterium exchange
Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide...
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7601504 |
Protein achieving improved blocking efficiency
It is intended to provide a method of conveniently screening a novel protein or a novel partial sequence protein having a blocking ability based on amino acid sequence data; and a protein achieving...
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7601507 |
Electronic methods for the detection of analytes
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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7601505 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast...
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7601517 |
Split protein self complementing fragments, systems, and methods of use thereof
Briefly described, embodiments of this disclosure include split protein systems, fusion proteins, methods of producing the split protein systems, methods of screening macromolecular delivery...
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7601540 |
Gamma secretase notch biomarkers
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity...
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7601502 |
Prime boost vaccine for the protection of equines against equine influenza
The present invention is concerned with vaccinating equines against the equine influenza virus (EIV). It has now been found that adequate protection against equine influenza in equines can be...
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7601684 |
Diagnosis and treatment of disorders of iron metabolism
The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The...
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7601506 |
Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
The invention provides a simple method for diagnosing a non-symptomatic or symptomatic human or animal with transmissible spongiform encephalopathy.
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7598081 |
Materials and procedures for the purification of cells
The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can...
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7598079 |
Assay for identifying compounds which affect stability of mRNA
The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect...
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7598042 |
Early prostate cancer antigens (EPCA), polynucleotide sequences encoding them, and their use
A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without...
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7598028 |
Compositions and methods for detecting and treating prostate disorders
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating cellular proliferation disorders and cellular motility disorders. In particular,...
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7598051 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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