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7622289 |
Ornithine aminotransferase (OAT): a target for anticancer drugs
Ornithine δ-aminotransferase (OAT) facilitates microtubule assembly in addition to its aminotransferase activity in mitochondria. An N-terminal proteolysis of the first 17 amino acids of OAT block...
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7622263 |
Kit for immobilizing organic substance, organic substance-immobilized structure, and manufacturing methods therefor
To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic...
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7622106 |
Necrosis assay
A necrosis assays is performed with a cell expressing RIPK1 and RIP3 by (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-α; and (b) detecting a resultant necrosis of the cell.
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7622260 |
Diagnostic and prognostic tests
The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides...
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7622265 |
Methods and compositions for modulating prostasin
The invention provides methods and compositions related to modulating prostasin.
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7622266 |
Identification of a synthetic ligand for retinoic acid receptor beta
A method for identifying a synthetic ligand for retinoic acid receptor β comprises providing a sample, including a synthetic compound, exposing the sample to cultured cells, wherein the cultured...
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7622256 |
Method for selecting compounds that modulate MIF-induced expression of ICAM-1 and/or VCAM-1
Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and...
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7622259 |
Detection of von-Willebrand factor (vWF) activity
The present invention relates to a method for detecting von-Willebrand factor (vWF) activity comprising assaying a sample in the presence of a soluble form or portion of glycoprotein Ib(α)...
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7622264 |
Methods for screening for modulators of CXCR3 signaling
CXCR3 is identified as a physiological receptor for Gliadin. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling...
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7622558 |
Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use
The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized...
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7622262 |
Method for diagnosing neoplasms
Disclosed are uses of Gangliosides G M1 and/or asialo-G M1 substances simulating the carbohydrate portion of said gangliosides with regard to bonding to anti-G M1 antibodies and/or anti-AD M1...
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7622114 |
Assay methods for immediate diagnosis of cause of stroke
A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor...
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7622249 |
Method for diagnosing and/or predicting of a septic syndrome
The present invention relates to a method for diagnosing and/or predicting a septic syndrome, wherein:
a. a biological sample from the patient is made available and biological material is...
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7618810 |
Metering strip and method for lateral flow assay devices
A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection...
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7618787 |
Method of screening compound capable of accelerating or inhibiting apoptosis, apoptosis accelarator and apoptosis inhibitor
A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.
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7618788 |
Proteome epitope tags and methods of use thereof in protein modification analysis
Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation,...
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7618654 |
Mammalian myeloid progenitor cell subsets
A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate...
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7618786 |
Method for identifying modulators of human orexin-2 receptor
The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor...
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7618783 |
Anthrax specific antibodies
The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis -specific monoclonal...
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7618782 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7619068 |
Ovr110 antibody compositions and methods of use
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also...
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7618790 |
Method for NGF assay for in vitro diagnosis of breast cancer and therapeutic use
The present invention concerns a method for the in vitro diagnosis of breast cancer which consists in determining the presence of NGF in a biological sample derived from a patient suspected of...
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7618587 |
Analyzers and methods of analyzing blood
Analyzers and methods of analysis are described for performing blood cell counting and immunoassay on a whole blood specimen in one measurement section. An assay sample is prepared by blending...
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7618785 |
Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors
A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1...
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7618640 |
Method and composition for reducing E. coli disease and enhancing performance
Bacillus strains that inhibit pathogenic swine E. coli and/or improve performance are provided. Inhibition of pathogenic swine E. coli decreases E. coli disease. At least one strain enhanced...
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7618772 |
Methods and compositions for diagnosing and suppressing metastasis thereof
Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis...
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7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
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7615354 |
Electrophoretic separation of compounds
A device, method and kit for the electrophoretic separation and purification of charged and neutral compounds in an analyte solution. The device comprises a chamber ( 1 ), at least one wall of...
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7615355 |
Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for...
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7615218 |
Methods for determining and lowering caffeine concentration in fluids
Single-chain, camelized heavy chain antibodies immunospecific for caffeine and stable at high temperatures are useful for analysis and recovery of caffeine in or from fluids. A device that provides...
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7615610 |
Modified trafficking patterns for arrestin and G-protein-coupled receptors via arrestin-ubiquitin chimera
The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the...
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7615347 |
Method for trapping nucleic acids using divalent metal ions
A method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and having a pH of 12 or higher with the...
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7615381 |
Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device
Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is...
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7615222 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7612174 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7611719 |
Enterovirus, vaccines, medicaments and diagnostic kits
The invention provides a new enteroviral species call EV79, and functional parts, derivatives and analogues of said virus. Proteinaceous molecules capable of specifically binding EV79, such as...
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7611847 |
Method for identifying an intestinal phenotype
The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the...
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7611908 |
Method and apparatus for therapeutic drug monitoring using an acoustic device
Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the...
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7611714 |
Methods and compositions for immunizing against Pseudomonas infection
Methods and compositions for inducing an immune response against Pseudomonas aeruginosa are provided herein. In one aspect, the invention provides a chimeric immunogen, comprising a receptor...
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7611866 |
Selection of bacterial inner-membrane anchor polypeptides
The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating polypeptides capable of anchoring heterologous polypeptides to a bacterial inner membrane. In...
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7611845 |
Serum levels of HER2/neu as an indicator of clinical state and prognosis of prostate cancer
The present invention relates to methods of diagnosing prostate cancer, predicting disease progression of prostate cancer, prognosing the stage and state of prostate cancer, and identifying...
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7613571 |
Method and system for the multidimensional morphological reconstruction of genome expression activity
A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the...
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7611904 |
Serpentine transmembrane antigens expressed in human cancers and uses thereof
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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7611480 |
Gastrointestinal bioreactor
An in-vivo bioreactor device producing a dialysis effect by acting within the gastrointestinal tract for the removal of undesirable concentrated intestinal or blood substances or metabolites is...
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7613573 |
Pricing of the identification service by a registry which identifies prospective donors having particular bloodtypes to a requisitioner
Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances...
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7611848 |
Method for selecting allosteric regulators of class III G protein-coupled receptors
A method for identifying and selecting a compound acting as an allosteric regulator of a GPCR-III is described. A method comparing the activity level of a recombinant GPCR-III (GPCR-III-Δ),...
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7611846 |
Diagnostic methods involving human growth factor huXAG-1
The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1,...
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7611720 |
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
The invention relates to a live recombinant Mycobacterium bovis -BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
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7611909 |
Near infrared chemiluminescent acridinium compounds and uses thereof
A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing...
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7612175 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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