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7432061 |
Assays for measuring matrix metalloproteinase activities
Methods for determining matrix metalloproteinase (MMP) activity in biological samples are described. The methods of the invention are useful to assess disease severity or progression, diagnose a...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7429457 |
Id-1 and Id-2 genes and products as markers of epithelial cancer
A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene...
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7429473 |
Diacylglycerol acyltransferase genes, proteins, and uses thereof
The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes and proteins that exhibit both long-chain...
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7429459 |
Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell
A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and...
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7429238 |
Systems and methods for the generation of crystalline polymorphs
The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7429389 |
Vaccines for Mycoplasma bovis and methods of use
The invention of novel, effective vaccines against Mycoplasma bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related...
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7427469 |
Method of treating cytomegalovirus with DC-SIGN blockers
The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at...
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7427399 |
Antibodies and related molecules that bind to 161P2F10B proteins
Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is...
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7427511 |
Immunochromatographic test device
An immunochromatographic test device of the present invention comprises: a sample receiving member for receiving a sample; a label holding member for holding a labeling substance to bind to an...
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7427490 |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount...
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7427659 |
Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
The present invention is a process for separating a target protein (such as a recombinant protein produced in a cell culture) from a mixture containing the target protein and contaminants (such as...
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7427485 |
Method for classification of anti-psychotic drugs
The present invention provides a method for identifying an agent to be tested for an ability to treat a psychotic disorder in a patient in need of such treatment. The invention provides a method...
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7427496 |
Anti-cancer compounds
The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the...
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7427486 |
Mullerian inhibiting substance levels and ovarian response
Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively...
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7427493 |
Recombinant genes for polyketide modifying enzymes
Materials and methods to produce modified polyketides are disclosed. The biosynthesis, transfer and regulator genes for various sugars to effectuate polyketide modification are disclosed.
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7427512 |
Light-controlled electrokinetic assembly of particles near surfaces
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7427468 |
Anti-TSG101 antibodies and their uses for treatment of viral infections
The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for...
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7425428 |
Recombinant DNA construct for HIV envelope polypeptides and polypeptides produced thereby
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7425455 |
Biosensor, magnetic molecule measurement device
A biosensor not requiring washing of an unbonded label molecular by analyzing an object to be measured such as an antigen, an antibody, a DNA, and an RNA through magnetic field sensing. The...
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7425418 |
Compounds that modulate processes associated with IgE production
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7425539 |
Factor IXa for the treatment of bleeding disorders
The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating...
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7425622 |
Antibodies against C3a receptor
The present invention relates to antibodies and related molecules that specifically bind to C3a Receptor. Such antibodies have uses, for example, in the prevention and treatment of asthma, allergy,...
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7425420 |
Identification of ligands by selective amplification of cells transfected with a 5HT2A receptor
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present...
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7425538 |
HAUSP-p53 interaction and uses thereof
The present invention provides methods for determining whether a subject has neoplasia, methods for assessing the efficacy of therapy to treat neoplasia in a subject, methods for assessing the...
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7422860 |
Optoelectronic detection system
The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7422859 |
Method for discrimination of metaplasias from neoplastic or preneoplastic lesions
The present invention relates to a method for discrimination of p16 INK4a overexpressing metaplasias from neoplastic or preneoplastic p16 INK4a overexpressing lesions by determination of the...
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7422858 |
Apparatus and method for separating viral particles from cells
A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a...
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7422862 |
Methods for identifying modulators of apoptosis
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
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7423017 |
Method for treating cartilage disorders
The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting...
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7422855 |
Multiplexing assays for analyte detection
High density multiplexing assays for proteins, nucleic acids, and other molecules are described based upon using mass spectrometry detection. A solid-state support assay format is utilized,...
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7422847 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells,...
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7422864 |
Method for measuring oxidized LDL-CRP complex and measurement kit
The present invention provides a method for measuring a “complex of oxidized LDL and CRP” which comprises using an “anti-CRP antibody”. An “anti-apoB antibody and/or anti-β2-GPI...
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7422846 |
Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
The present invention is related to a method of detecting the dysregulation of GPR86 activity.
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7422863 |
Molting hormone receptor and method for screening ligand to the receptor
The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting...
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7419792 |
Laminin Receptor 1 Precursor Protein (37LRP) epitope delineated by an Hepatocellular carcinoma specific antibody
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to such diagnosis and treatment which revolves around the ability of the 5LAC-23 monoclonal antibody (or...
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7419804 |
CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as...
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7419821 |
Apparatus and methods for analyte measurement and immunoassay
The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the...
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7419777 |
Method and quantification assay for determining c-kit/SCF/pAKT status
This invention provides methods for determining or predicting response to cancer therapy in an individual using differential image analysis of immunohistochemically stained tumor samples.
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7419780 |
Methods and assays for screening protein targets
A method for identifying a protein as being able to bind a ligand comprising, providing a molecule composed of a methotrexate moiety that is covalently bonded to the ligand; introducing the...
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7419791 |
Methods of screening compounds using a T1R3 hetero-oligomeric taste receptor
Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding...
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7419789 |
Method of inhibiting binding of Dengue virus to a human cell with DC-SIGN blockers
The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at...
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7419784 |
Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are...
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7420032 |
Dominant B cell epitopes and methods of making and using thereof
Disclosed are methods for obtaining at least one epitope suitable for detecting the presence of an antibody against a tumor associated antigen of a cancer in a sample. Kits, assays, and substrates...
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7419790 |
Sodium-independent transporter carrying acidic amino acid and its gene
It is intended to provide a sodium-independent transporter carrying an acidic amino acid and its gene. A protein having the amino acid sequence represented by SEQ ID NO: 1 and being capable of...
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7419779 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids”...
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7419788 |
Method for screening anti-bacterial agents
The invention provides a method of screening for potential anti-bacterial agents being antagonists of the transpeptidase enzyme involved in peptidoglycan biosynthesis in bacteria. The method is...
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7419795 |
Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular,...
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