|
Match
|
Document |
Document Title |
|
|
7452727 |
Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit...
|
|
|
7449300 |
Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells
The invention provides methods of removing B7-H1-specific antibodies from a body fluid (e.g., blood), methods of diagnosing and treating diseases and pathological conditions mediated by activated T...
|
|
|
7449176 |
Treatment of inflammatory bowel disease with IFN-γ inhibitors
The invention concerns a method for the prevention or treatment of inflammatory bowel disease by administering an interferon-γ inhibitor. The invention further concerns pharmaceutical compositions...
|
|
|
7449292 |
Methods for predicting relative efficacy of a beta blocker therapy based on a B1-adrenergic receptor polymorphism
Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of β 1 -adrenergic receptor are provided. The Gly389 β 1 -adrenergic...
|
|
|
7449302 |
Therapeutic peptides
The present invention provides a ligand isolated from Moraxella catarrhalis outer membrane protein which binds to CEACAM receptors, said ligand comprising a receptor binding domain comprising an...
|
|
|
7449296 |
Method and kit for detecting porcine reproductive and respiratory syndrome virus
The invention provides methods, devices, and kits for the detection of a class of porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV, in a biological fluid. The invention is based...
|
|
|
7449301 |
Pharmaceutical composition and method for activating macrophage using the same
A pharmaceutical composition is produced by obtaining an antibody which specifically recognizes an extracellular domain of SIRPβ and formulating the antibody with a pharmaceutical acceptable...
|
|
|
7449560 |
Phosophoinositoglycan binding proteins
The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin...
|
|
|
7445902 |
Fluorescent nucleotide analogues
The present invention provides fluorescent cyanine dye-based nucleotide analogues, in which the cyanine dye is coupled to the γ-phosphate group of a nucleoside triphosphate. Preferred embodiments...
|
|
|
7445766 |
Medical device and method for diagnostic sensing
Devices are provided for use in medical diagnostics which include a substrate, a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening, at least one...
|
|
|
7445889 |
Methods for detecting parvovirus infections
The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19...
|
|
|
7445940 |
Method for diagnosing increased risk of preeclampsia
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-beta 3, receptors of cytokines of the TG beta...
|
|
|
7446180 |
Conformationally abnormal forms of tau proteins and specific antibodies thereto
Invention relates to antibodies with a specificity to an abnormally truncated form of tau protein which is conformationally different from normal tau and does not bind to normal tau protein,...
|
|
|
7447595 |
Heterologous protein production using the twin arginine translocation pathway
Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided,...
|
|
|
7446174 |
Protein based TNF-α variants for the treatment of TNF-α related disorders
The invention relates to novel proteins with TNF-α antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of...
|
|
|
7445906 |
Method of detecting cancer using delta-catenin
The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as...
|
|
|
7445903 |
Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
|
|
|
7445886 |
Macrophage migration inhibitory factor as a marker for cardiovascular risk
Macrophage migration inhibitory factor (MIF) is a clinically useful biochemical marker of cardiovascular risk. Risk assessment includes the step of detecting in the blood of a person MIF...
|
|
|
7442512 |
Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents...
|
|
|
7442513 |
Method of screening for agents that modulate a homer signaling pathway
The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of...
|
|
|
7442518 |
Imaging regulated protein-protein interactions in cells and living animals by enhanced luciferase protein fragment complementation
An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both...
|
|
|
7442774 |
INGAP displacement assays
An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can...
|
|
|
7442522 |
Nucleic acids encoding chromo or fluorescent proteins and method for using the same
Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this...
|
|
|
7442511 |
Adipogenic adenoviruses as a biomarker for disease
This invention relates to the relationship between infection with adipogenic adenoviruses, such as adenovirus-36 (Ad-36) and the etiologies of obesity and obesity-related cancers and other...
|
|
|
7442921 |
Protein profiles with atmospheric pressure ionization
The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to...
|
|
|
7442517 |
Method for the detection of Salmonella enterica serovar Enteritidis
Described herein is the identification of a novel Salmonella enterica serovar Enteritidis locus that serves as a marker for DNA-based identification of this bacterium. In addition, three primer...
|
|
|
7442521 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same
Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this...
|
|
|
7442514 |
Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
|
|
|
7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
|
|
|
7442773 |
Universal peptide-binding scaffolds and protein chips
The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated...
|
|
|
7442497 |
Methods of determining chronic hepatitis C infection
Methods for determining chronic hepatitis C infection are provided by the present invention. The methods generally involve determining the optical density of fluid samples which have tested...
|
|
|
7438920 |
Crystals of hepatitis C virus helicase or fragments thereof comprising a helicase binding pocket
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an...
|
|
|
7438892 |
Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA...
|
|
|
7439079 |
Assay devices having detection capabilities within the hook effect region
A lateral flow assay device for detecting the presence or quantity of an analyte within a test sample is provided. The device utilizes multiple zones, one of which serves as an indicator of whether...
|
|
|
7439334 |
Method of arrangement of titanium-binding ferritin and inorganic particles
A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin...
|
|
|
7438913 |
Substances and their uses
Polypeptides capable of binding human IL-13 and/or of binding human IL-4 in the presence of IL-4 Rα can be used in medicine, in diagnosis and in screening for agonists/antagonist of IL-13/IL-4....
|
|
|
7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
|
|
|
7439025 |
Antibodies binding a gamma carboxyglutamic acid displaying epitope
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while...
|
|
|
7439327 |
Stem cell factor-like proteins and uses thereof
The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4 v polynucleotides and polypeptides. The invention further relates to the...
|
|
|
7439028 |
Methods and compositions to correlate Trichomonas infection with prostate cancer
The present invention provides methods and compositions for identifying a subject at increased risk of having prostate cancer by detecting an antibody that specifically binds a Trichomonas ...
|
|
|
7439023 |
Method of isolating a nucleic acid using a material containing an amino group and a carboxyl group and positively charged at a first pH and a solid material for nucleic acid isolation used for the method
Provided are a method of isolating a nucleic acid from a sample and a solid material for isolating the nucleic acid which can be used for the above method. The method includes contacting the sample...
|
|
|
7439027 |
Method for modulating process mediated by farnesoid activated receptors
Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in...
|
|
|
7439321 |
Peptides for detection of antibody to Anaplasma phagocytophilum
The invention provides compositions and methods for the detection and quantification of A. phagocytophilum (formerly known as Ehrlichia equi ) antibodies and antibody fragments.
|
|
|
7438911 |
Antibody against human insulin-like growth factor
For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and...
|
|
|
7439026 |
Methods and kits for detecting ITA in a biological sample
Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect...
|
|
|
7438854 |
Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
A test apparatus is for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. A substrate is provided on which a...
|
|
|
7438908 |
Anti-human tenascin monoclonal antibody
A novel anti-human tenascin ST2146 monoclonal antibody is described endowed with high affinity with the native antigen and high tumor selectivity. The cST2146 hybridoma is stably producing the...
|
|
|
7439039 |
Assays for novel serotonin transporter (SERT) blockers
The serotonin transporter (SERT) is a target of various therapeutic agents used in the treatment of neurological and neurodegenerative disorders. The present invention provides novel forms of SERT...
|
|
|
7439055 |
Biomolecular detection device
A device for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with...
|
|
|
7435385 |
Label-free high-throughput optical technique for detecting biomolecular interactions
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
|