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7476509 |
Compounds and methods for modulating functions of nonclassical cadherins
Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin-mediated functions, are provided. The modulating agents...
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7476545 |
Method of quickly detecting and/or assaying antigen by fluorescence correlation spectrometry
The present invention provides a method of quickly and accurately detecting and/or assaying an antigen using fluorescence correlation spectroscopy (FCS), which involves a fluorescence-labeled...
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7476786 |
Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (SPM) reading
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the...
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7476656 |
Fluorescent affinity tag to enhance phosphoprotein detection and characterization
The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by...
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7473770 |
Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
The cynomolgus monkey Dickkopf-4 (cDkk-4) protein, isolated nucleic acid molecules which encode the cDkk-4 protein, and recombinant vectors and hosts comprising DNA encoding the cDkk-4 protein are...
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7473549 |
Target recognition element and biosensor including the same
The present invention provides a target recognizing element wherein a receptor is fixed to an inclusion complex containing a mediator. The target recognizing element includes a first host molecule...
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7473564 |
Kit and method for detecting the ESM-1 protein
The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising:
a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between...
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7473679 |
Treatments employing neuronal exocytosis-inhibiting peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
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7473543 |
Thrombin compositions
Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7-7.4 consisting essentially of 0.1 mg/mL to 5.0...
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7473531 |
Pancreatic cancer targets and uses thereof
The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic...
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7470513 |
Risk assessment for adverse drug reactions
The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is...
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7470518 |
Systems and method for rapidly changing the solution environment around sensors
The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also...
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7470519 |
Methods for detecting TAFIa or TAFIai
The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof,...
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7470379 |
Inorganic particle conjugates
The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
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7470669 |
Isolated polypeptide comprising a leptin fragment
The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related...
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7468253 |
Method for multiple chemokine receptor screening for antagonists using RAM assay
The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific migration blockers.
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7468252 |
Methods for tissue analysis
This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in...
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7468256 |
Tools for detecting Moraxella catarrhalis
The present invention provides compositions and methods useful for detecting Moraxella catarrhalis . The compositions are antibodies, proteins or nucleic acid sequences specific to Moraxella...
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7465548 |
Methods of screening for potential therapeutics for diseases associated with G-protein coupled receptor HM74a
The invention provides a human HM74a which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation,...
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7465556 |
Method of immunoassay tartrate resistant acid phosphatase 5b and kit to be used therein
Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b...
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7465551 |
Method of determining cytokine dosage for improving myelosuppressive state
The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By...
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7465555 |
Early detection of sepsis
Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis.
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7465550 |
Method for screening taste-modulating compounds
The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic...
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7465449 |
Anti-αvβ6 antibodies
Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose %...
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7465427 |
Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology
A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer...
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7465547 |
Methods for detecting human low molecular weight CD14
The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human...
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7465541 |
Vitamin D3-responsive sequences located 5′-upstream of p27/kip 1 gene and methods of screening for pharmaceutical agents using the sequences
A 44-bp region that confers vitamin D 3 -responsiveness to the human p27 Kip1 promoter in the human p27 Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin...
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7465549 |
Methods for identifying agents that bind a levetiracetam binding site (LBS) or compete with LEV binding to a LBS of a synaptic vesicle protein 2 (SV2)
The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which...
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7462697 |
Methods for antibody engineering
The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method...
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7462324 |
Measurement device and method for measuring electric signal from biological sample
A measurement device 10 includes a measurement cell 11 . The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17 . The substrates 16 and 17 are...
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7462458 |
Methods of detecting ovarian neoplasia
Methods for diagnosing ovarian neoplasia, monitoring ovarian cancer therapy, and monitoring progression of disease in subjects based on the level of the proform of major basic protein in biological...
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7462457 |
Identification of activated receptors and ion channels
The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.
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7462459 |
LAT1 transporters expressed in blood brain barrier cells
LAT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is...
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7462454 |
Treatment of herpes
The present invention includes methods for the treatment of a herpes simplex virus infection comprising the administration of inhibitors of gamma interferon, tumor necrosis alpha and interleukin-1.
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7462461 |
Compositions for inhibiting Sema7A and VLA-1 interaction and the methods of using the same
Disclosed are compositions and methods of treating a cytokine mediated diseases by inhibiting Sema7A and VLA-1 interaction.
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7462491 |
Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin
Serum cav-1 is disclosed as a biomarker for prostate cancer that has the power to differentiate between prostate cancer and BPH patients.
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7462460 |
Methods for identifying agents that increase the p44 function of microtubule assembly or resistance to HCV infection
The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a...
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7462495 |
Methods and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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7459528 |
Glycoproteins which bind to TNF
Tumor necrosis factor receptor DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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7459279 |
Binding assay employing IGS4, a human G-protein coupled neuromedin receptor
The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such- polynucleotides and polypeptides, and to their production. More particularly,...
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7459304 |
Method for analysing macromolecules
The invention relates to a method for the analysis of macromolecules using a microarray on which a plurality of first at least partly different macromolecules are located in a known arrangement,...
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7459437 |
Molecular determinants of myeloma bone disease and uses thereof
To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients...
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7459277 |
Mammalian T1R3 sweet taste receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled...
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7459278 |
System and method for large scale detection of hazardous materials in the mail or in other objects
A system and method that enables early detection of hazardous materials, such as explosives and biological materials, in the early phases of mail handling or processing.
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7459525 |
Factor VIII glycoforms
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
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7459300 |
Polypeptide Hormone Phosphatonin
The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant...
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7459281 |
Docetaxel immunoassay
Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in...
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7459317 |
Method for detecting an analyte in a sample
Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label...
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7459436 |
Treatment of disturbances of iron distribution
The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in heart diseases.
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7459276 |
Methods and controls for monitoring assay quality and accuracy in parathyroid hormone measurement
The present invention relates to the use of control compositions and kits comprising such to evaluate and monitor the consistency of assays utilized to determine parathyroid hormone levels.
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