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8846872 Monoclonal antibodies and diagnostic uses thereof  
The disclosure relates to antibodies to the preferentially expressed antigen in melanoma (PRAME), and the synovial sarcoma X breakpoint 2 (SSX-2) antigens, methods of use, and diagnostic kits...
8846881 Modular nucleotide compositions and uses therefor  
Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide...
8846411 Derivatives, reagents, and immunoassay for detecting levetiracetam  
Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase...
8846322 Method and kit for isolating target cell  
Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target...
8846413 Method for determining the concentration of the adipocytic form of the fatty acid binding protein (A-FABP, FABP4, P2)  
Products and methods for the research, diagnosis, risk assessment, course monitoring, treatment and prophylaxis of various metabolic disorders and their early forms, concomitant diseases and...
8841082 Method and device for the determination of minor cell population in heterogeneous cell populations  
The invention relates to a method for determining one or more cellularly bound analytes in a liquid sample, said method being carried out using a device comprising: at least one feeding zone (5)...
8841079 Fibronectin aggrecan biomarker for the identification of spinal and joint source of pain  
Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for...
8841067 NOL3 is a predictor of patient outcome  
The present invention features a method for determining the prognosis for survival of a cancer patient. Methods for measuring the level of NOL3 expression in a cancer cell-containing sample from a...
8841077 Biomarkers for amyotrophic lateral sclerosis and methods using the same  
The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for...
8841078 Dual activity kinase domains and uses thereof  
The present invention relates to a dual activity domain of JAK proteins, namely JH2. It is provided that the JH2 domain is a true and important target for drug development, especially for diseases...
8841084 Methods for the detection and monitoring of acute myocardial infarction  
Disclosed herein are methods of detecting and/or prognosing myocardial infarction by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The myocardial...
8841136 Levetiracetam immunoassays  
Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of...
8841076 Systems and methods for conducting animal studies  
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The...
8835122 Methods and system for the automated determination of immunofluorescent foci using a cell-based immunofluorescence assay using synthetic calibration particles  
The invention relates to a method for automated determination of immunofluorescent foci by means of an immunofluorescence assay using synthetic calibration particles, in addition to a system and...
8835125 Methods and compositions for selective labeling of different biotinylated targets within multicolor or multilabel assays  
Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within...
8835119 Lectin pathway deficiency assay  
The invention refers to an in vitro method of functionally determining at physiological conditions deficiencies in the lectin pathway of the complement system, the method comprising the steps of...
8834794 Apparatus and methods for detection of tumor cells in blood  
In one embodiment, the present invention provides the description of an inexpensive and disposable handheld device for detecting Circulating tumor cells (CTC) in blood called a handheld CTC...
8835188 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8835144 Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate  
Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials....
8835113 Methods and compositions for assaying a sample for an aggregant  
This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor...
8835171 Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol  
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation...
8835187 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8835120 Assay for cardiac troponin-T (cTnT)  
The present disclosure describes immunoassays for detecting cardiac troponin-T (cTnT) in a test sample, and in particular immunoassays and kits for detecting cTnT in a test sample suspected of...
8835121 Modified method of agglutination to detect infections caused by microorganisms  
Provided herein is a modified method of agglutination to detect infections caused by microorganisms including the steps of staining the test serum, plasma or blood or purified antibodies with a...
8835127 Optoelectronic detection system  
The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the...
8828668 Markers for determination of patient responsiveness  
Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the...
8828671 Simultaneous assay of target and target-drug binding  
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
8828657 Susceptibility variants for lung cancer  
The present invention discloses certain genetic variants as susceptibility variants for lung cancer. The invention relates to methods of risk assessment using such variants. The invention further...
8828738 Amelioration of heterophile antibody immunosensor interference  
The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the...
8828713 Sensors using high electron mobility transistors  
Embodiments of the invention include sensors comprising high electron mobility transistors (HEMTs) with capture reagents on a gate region of the HEMTs. Example sensors include HEMTs with a thin...
8828676 Methods for differentiating plasma-derived protein from recombinant protein in a sample  
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
8828667 Methods and compositions relating to isocyanate conjugates  
Compositions are provided according to embodiments of the present invention which include an isolated antibody or antigen binding antibody fragment characterized by binding specificity for a...
8828670 Method for the production of proteins and peptides  
The invention relates to a method for producing monomeric or dimeric proteins or peptides containing internal or external disulfide bonds, comprising the following steps: a) a cell-free lysate,...
8828669 Methods of screening for a compound that inhibits the interaction between BAFF and BCMA  
A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
8828665 Compounds and methods for use in detecting gabapentin  
Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A...
8828672 PARP substrates and biomarkers  
PARylated proteins are enriched by treating cell lysates comprising PARylated proteins and DNA/RNA with an endonuclease that cleaves the DNA/RNA but not the PAR; and separating the PARylated...
8828666 Method for measuring bonding activity of antibody which mimics antibody-dependent cell medicated cytotoxic activity  
The present invention provides a simple method which is capable of evaluating the binding activities of an antibody to both an antigen and an Fe receptor. Disclosed is a method of measuring the...
8829162 In vitro method for diagnosing prostate cancer  
The invention relates to an in vitro method for diagnosing prostate cancer and to antibodies and fragments thereof directed against CK2-α and their use for the diagnosis and prognosis of prostate...
8828741 Method and device for the detection of molecular interactions  
The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes,...
8821872 Identification and characterization of a specific CCK-C receptor antibody for human pancreatic cancer and its use for early detection and staging of pancreatic cancer  
Human pancreatic cancer cells possess a distinct plasma membrane CCK receptor variant that can be differentiated from the classic CCK-B receptor with selective monoclonal antibodies. Use of this...
8822168 Assays for detecting small nuclear ribonucleoprotein particle assembly and survival of motor neurons activity  
The present invention includes assays and kits for detecting the assembly of an RNA binding protein-RNA complex and for detecting the activity of an RNA binding protein.
8822163 Method for measuring β-glucan, and β-glucan-binding protein for use in the method  
Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which...
8822164 Biomarkers for lymphoma  
A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person...
8822229 Method for assaying keratan sulfate, assay kit therefor and method for detecting joint disease by using the same  
The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological...
8822143 Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents  
Particular aspects provide a method of sampling, testing and validating test lots (e.g., single-unit production lots), comprising: assembling a plurality of product portions from each of a...
8822162 Cyanochrome fluorophores  
Genetically-engineered cyanochrome fluorophore molecules (fluorophores) with increased fluorescence and with absorbing fluorescence in the blue and green (blue/green) portion of the light spectrum...
8821856 Method of targeted gene delivery using viral vectors  
Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant...
8822231 Assay method and device  
A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate...
8822179 Nucleic acid compositions and the encoding proteins  
The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes...
8822645 Prostaglandin E2 dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.