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8895253 Integrin heterodimer and a subunit thereof  
A recombinant or isolated integrin heterodimer comprising a novel subunit α10 in association with a subunit β is described. The α10 integrin may be purified from bovine chondrocytes on a...
8895259 Method for determination of platelet function under flow conditions  
The invention lies in the area of platelet function diagnostics and relates to an in vitro method for the determination of platelet function under flow conditions. The method is particularly...
8895011 Insulin-resistance-improving drug  
Provided are a means for the prevention and treatment of obesity and/or insulin resistance and, particularly, pharmaceutical drugs for the treatment of obesity and/or insulin resistance under the...
8895294 Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm  
Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions...
8889366 Marker for graft failure and mortality  
Subject of the present invention is a biomarker for graft failure and/or mortality after organ transplantation. Procalcitonin was found to be a useful marker for the prediction or risk...
8889883 BODIPY structure fluorescence dye for neural stem cell probe  
The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The...
8889365 Methods and kit for detecting breast cancer  
The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary...
8889138 Anti-ADDL antibodies and uses thereof  
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can...
8889363 Method for the detection and identification of a variant C. difficile strain in a sample  
The method for detecting and identifying a variant C. difficile strain in a sample is characterized by the following steps: (a) obtaining a sample of excreta or tissue from a human or animal...
8889424 Device and method for performing a diagnostic test  
A device and method for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample (e.g., a body fluid). A device may include an...
8889364 Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers  
The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver...
8889370 Method of determining inhibitors of coagulation  
A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test...
8889362 Cell classification system  
The present invention involves the reaction of a CD4 immuno-conjugate with a sample of patient whole blood. The CD4 immuno-conjugate consists of one or more antibodies with specificity for the CD4...
8889132 Antibodies against human HIF-1α  
The invention relates to reagents and methods for detecting, diagnosing and screening for conditions associated with hydroxylated hypoxia inducible factor 1-α (HIF-1α). The invention also relates...
8889369 Method for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates  
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody...
8883427 Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments  
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting...
8883173 Synthetic antigenic peptides and lipopeptides derived from Mycobacterium avium subsp. paratuberculosis  
The current invention relates to the diagnosis and treatment of diseases resulting from infections by Mycobacterium avium subsp. paratuberculosis. In particular the invention relates to the use of...
8883429 Viral diagnostics  
The present disclosure provides methods for determining whether a subject is infected with lymphocytic choriomeningitis virus (LCMV). These methods include obtaining a sample from a subject with...
8883428 Methods to determine atherosclerosis regression, plaque stabilization and cardiovascular risk  
Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD).
8883970 Alpha-amylase variants  
The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one...
8883441 Method for detecting and counting micro-organisms in a sample  
A method for detecting and counting the microorganisms in a sample is described. The method comprises: a) selectively enriching the microorganism sought in the sample,b) inducing or activating at...
8883431 Compositions and methods for immunodominant antigens of Mycobacterium tuberculosis  
Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In...
8883426 Use of therapeutically effective lipids and method for producing organ-/tissue-specific therapeutically effective lipids  
The use of therapeutically active lipids for organ/tissue-specific enrichment for the treatment of inflammatory, ischemic or degenerative disorders and/or for stimulating a regeneration is...
8883510 Thrombocyte function determination method using a resonator  
The invention relates to a method for determining haemostasis parameters by measuring vibration parameters of a resonator having a measuring surface which contacts a platelet containing sample...
8883430 Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells  
A substantially pure population of human somatic cells that have enhanced potential to become induced pluripotent stem cells (iPS cells) is provided. Also provided are methods for generating this...
8883433 Method for in vitro assay of soluble fibrin by generating specific degradation products  
The invention concerns a method for assaying soluble fibrin in a sample, in which said sample is brought into the presence of a plasminogen activator with a high specificity for soluble fibrin...
8883417 Clinically intelligent diagnostic methods utilizing micromixers disposed in wells  
The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical...
8877453 Diagnosing and managing venous thromboembolism and intracardiac thrombi using a provoked D-dimer test  
The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention...
8877516 Detection of biomarkers and biomarker complexes  
The invention features methods and devices for the detection of biomarker complexes and their components and for the sequential detection of multiple epitopes of a biomarker. The invention also...
8877449 Method for obtaining pancreatic progenitor cell using NEPH3  
The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by...
8877450 Dual path immunoassay device  
Systems include test cells with sorbent material in a T-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized...
8877448 Method of making recombinant influenza virus  
The invention provides a composition useful to prepare influenza A viruses, e.g., in the absence of helper virus.
8877436 Fast results hybrid capture assay on an automated platform  
The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
8877518 Multiplexed nanoscale electrochemical sensors for multi-analyte detection  
Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices.
8877447 Detection of glutathionylated proteins  
The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and...
8877514 Aqueous solution for use as medium for the specific binding reaction of a binding pair  
The present invention refers to an aqueous solution for use as medium for the specific binding reaction of a binding pair, wherein a first binding member recognizes its complementary second...
8871448 Diagnosis of preeclampsia  
The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples...
8871453 Method of predicting acute appendicitis  
Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers:...
8871452 Methods for treatment of cardiovascular disease  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8871449 Methods and products for evaluating an immune response to a therapeutic protein  
The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to...
8871450 Biomarker for colorectal cancer  
The present invention relates to new methods for predicting the clinical outcome or determining the treatment course in a subject afflicted with solid tumors, like colorectal cancer, and for...
8871442 Enhanced deposition of chromogens  
This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The...
8871438 Disease diagnosis method, marker screening method and marker using TOF-SIMS  
The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a...
8871447 Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence  
Compositions of matter that comprise one or more conformational epitopes found on amyloid peptide aggregates, antibodies to such epitopes and methods for making and using the compositions,...
8871444 In vitro evolution in microfluidic systems  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalizing genetic elements into...
8871518 Monoclonal antibody for analyzing high-molecular weight adiponectin and utilization of same  
A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed....
8871451 Extracellular and membrane-associated prostate cancer markers  
This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting...
8871454 Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)  
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal...
8871917 Compositions for the detection of biological molecules using a two particle complex  
Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps...
8865417 Assays for the detection of anti-TNF drugs and autoantibodies  
The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for...