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8945855 Method for engineering proteases and protein kinases  
Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects,...
8945869 Factor VIII glycoforms  
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
8945860 Highly sensitive monoclonal antibody residual detection assay  
The present invention relates to compositions and highly sensitive methods for the detection of biotechnology product residual when monitoring product carry over and/or for cleaning verification...
8945853 Detection of intracellular binding events by measuring protein abundance  
Methods and compositions are provided to measure the binding of a test compound to a target peptide by measuring the effect of the compound on the abundance of the target peptide inside a cell....
8945945 Sample collection and analysis  
Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards....
8940488 Cancer diagnosis and treatment of cancer using anti-robo 1 antibody  
A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody...
8940489 Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody  
Disclosed are a monoclonal antibody against human D-dimer produced in a mouse and high molecular weight cross-linked fibrin including a corresponding epitope, a cell line secreting the monoclonal...
8940298 High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection  
The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis,...
8940234 Biosensor utilizing a resonator having a functionalized surface  
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In...
8940492 Calibrator/control for simultaneous assay of proteins capable of complexing with one another  
Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such...
8940490 Neoantibodies for diagnosing tissue injury  
A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of...
8940491 Genotoxicity as a biomarker for inflammation  
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An...
8940506 High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins  
The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of...
8936791 Method for in vitro diagnosis of PVL-producing Staphylococcus aureus  
A method for in vitro diagnosis of Staphylococcus aureus producing Panton-Valentine Leukocidin (PVL), using a biological sample derived from an individual liable to be colonized by or infected...
8936914 Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX  
The present invention provides methods of aiding in a renal cell carcinoma prognosis that include quantifying expressed carbonic anhydrase in samples derived from renal cell carcinoma patients....
8936915 Cleavage sensitive antibodies and methods of use thereof  
We disclose cleavage-sensitive antibodies with epitopes spanning the scissile bond of the toxins molecular target protein, enabling toxin-associated proteolysis to be measured in a variety of...
8937756 Method for and use of digital holographic microscopy and imaging on labelled cell samples  
The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained...
8932857 Method for selecting reduced differentiation resistance human induced pluripotent stem cells  
The present invention provides a method for selecting human induced pluripotent stem (iPS) cells which can be safely used for transplantation. That is, the present invention provides a method for...
8932820 Methods and kits for determining von Willebrand factor activity in the absence of ristocetin and for determining the activity of ADAMTS-13 protease  
Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
8932819 Assays for affinity profiling of nucleic acid binding proteins  
Methods, compositions and kits are disclosed for assays to determine the binding affinity of DNA-binding proteins or RNA-binding proteins for their corresponding recognition site(s). In...
8932992 Templated molecules and methods for using such molecules  
The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis...
8932824 Method of detecting cancer using delta-catenin  
The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such...
8932822 Methods for detecting allosteric modulators of protein  
The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents...
8932821 NOGO receptor binding protein  
The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides...
8932879 Methods and compounds for phototransfer  
Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through...
8932823 Methods for determining the risk of prenatal complications  
The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain...
8927221 Diagnostic marker for kidney diseases and use thereof  
The present invention relates to novel diagnostic markers for kidney disease and the use thereof.
8927695 Protein-based assays for screening of the IgE-receptor interaction  
Embodiments of the invention are related to a polypeptide comprising the amino acid sequence of a human IgE-Fc Cε3-Cε4, wherein said Cε3-Cε4 starts at amino acid 328 and ends at amino acid 547 of...
8927222 Method for the isolation of proteins binding to any kind nucleic acid sequence of interest  
The invention is to supply a novel way for the isolation and identification of proteins bound to any kind of interesting nucleic acid sequence (Sequence-of-Interest: SoI), advantageously to any...
8927290 Compositions and methods for the detection of antibodies to native human leukocyte antigen  
Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection...
8927219 Method for evaluation of quality of blood sample  
A method for evaluating the quality of a blood sample, comprising the steps of: mixing labeled anti-cortisol antibodies with a blood sample to be subjected, to conduct the antigen-antibody...
8927205 Recombinant polypeptides of the members of the TNF ligand family and use thereof  
The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the...
8927298 Sample collection and analysis  
Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards....
8927210 Conjugate complexes for analyte detection  
The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an...
8927297 Methods to measure dissociation rates for ligands that form reversible covalent bonds  
The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands...
8927220 Method for diagnosing immunoglobulin A nephropathy and TGBM nephropathy  
A protein used as a biomarker for diagnosing IgA nephropathy and TGBM (thin-glomerular-basement-membrane) using urine through a target proteomics method. A diagnosis biomarker protein and a kit...
8927223 Immunoassay methods  
The application generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid,...
8921054 Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions  
Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death...
8920798 Myostatin binding agents, nucleic acids encoding the same, and methods of treatment  
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
8920789 Use of polymer D-lactic acid (PDLA) or equivalents thereof to inhibit growth of cancer cells and diagnose cancers  
The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or...
8921053 Biomarkers for head-and-neck cancers and precancers  
The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers and related disease conditions in a subject. The invention also provides localization...
8921052 Hemoglobin derivative measurement method, and reagent composition, measurement kit, analysis device and analysis system for use in the method  
A sample solution including blood components is processed with a denaturalization reagent comprising a nonionic surface-activating agent and an oxidizing agent to denaturalize a hemoglobin...
8921066 Compositions and methods for adhesion of intact cells to an apparatus  
Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also...
8921070 Method for the urinary detection of bladder cancer  
The invention relates to the diagnosis of bladder cancer and more specifically to the detection in urine samples of bladder carcinomas of the transitional type. The detection method according to...
8921051 Methods and means for typing a sample comprising colorectal cancer cells  
The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said...
8921113 Buffer kit and method of generating a linear pH gradient  
A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt,...
8921055 Detecting cells secreting a protein of interest  
In some cases, the described systems and methods include obtaining a cell sample containing multiple antibody-producing cells. In such cases, the cells can be tagged with a cross-linking reagent...
8920718 Methods and devices to generate luminescence from integrated electrode chips by cathodic and bipolar pulses  
The invention describes novel chemiluminescence electrode devices and their novel properties to enable achieving luminescence signal by electrical excitation by cathodic or bipolar pulses in...
8916389 Sensor element for SPR measurement  
An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a...
8916342 Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers  
A method and a kit for determining a disease stage of a papilloma virus infection in a human subject is disclosed. The method comprises: obtaining a sample from said human subject, said sample...