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8969015 Methods and kits for diagnosing Sjögren's syndrome  
The invention features methods and kits for determining the presence of, or a predisposition to develop, Sjögren's syndrome in humans. The invention features methods to detect changes in the...
8969016 Resonance energy transfer assay with cleavage sequence and spacer  
A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at...
8969024 Compositions and methods comprising binding proteins for adalimumab  
Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to...
8969017 Metabolite biomarkers for diagnosis and prognosis of pediatric septic shock  
The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome...
8968997 Benzoxazole-based fluorescent metal ion indicators  
Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses...
8962263 Methods and compositions for detecting the activation state of multiple proteins in single cells  
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
8962592 Methods of treating a meiotic kinesin associated disease  
The invention provides methods of treating a meiotic kinase-associated disease, preferably the meiotic kinase HSET, by administering an inhibitor of the meiotic kinase. Preferably, the disease is...
8962558 Methods for reducing GnRH-positive tumor cell proliferation using the GnRH antagonist IN3  
A method for recognizing and evaluating the presence and function of GnRH receptors on tumor cells including those originating in the brain and/or nervous system and/or the meninges and/or...
8962269 Spinal muscular atrophy diagnostic methods  
The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention...
8962237 Method of detecting and identifying circulating antigens in human biological samples  
Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a...
8962261 Autoantibody biomarkers for IGA nephropathy  
Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject. In practicing one aspect of the subject methods, a sample from a subject is analyzed for the...
8962256 Surface-assisted hemagglutination and hemagglutination inhibition assays  
Hemagglutination (HA) and hemagglutination inhibition (HAI) functional assays remain important instruments of analysis of virus-cell interaction and protecting efficacy of virus-specific...
8962260 Method and device for combined detection of viral and bacterial infections  
A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for...
8962341 Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis  
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in...
8962258 Apparatus and method for multiple immunoassays on a chip  
Provided are a multiple immunoassay apparatus on a chip in which a structure comprising multiple microfluidic channels is associated with a tissue sample, which allows immunohistochemical...
8962239 Methods useful for vitamin D deficiency and related disorders  
Methods for diagnosing, treating, and preventing catabolism-related vitamin D deficiency and related disorders, related compositions, apparatus and kits, are disclosed. A method involves measuring...
8962345 Method of characterizing glycans attached to glycoproteins  
A method of characterizing glycans attached to glycoproteins is disclosed herein. The method comprises a first step of immobilizing the glycoproteins on colloidal particles forming...
8962264 Non-heating detection method for dermatophyte  
The present invention provides a method of detecting dermatophyte, which does not require a complicated operation such as an enzyme treatment and a heat treatment. The present invention provides a...
8962257 Methods for diagnosing heart failure and other cardiac diseases  
The invention relates to methods of diagnosing the severity of heart failure or a cardiac dysfunction in a subject. The invention further relates to monitoring the severity of heart failure in a...
8962259 Recombinant antigen for detection of toxocariasis  
A vector comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO: 2 for detecting antibody against Toxocara spp. in a biological sample.
8956823 Anti-antibody reagent  
An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in...
8956877 Separation-free assay method  
A separation-free assay including a binding partner, a binding partner labeled with a directly luminescent label, and a nonspecifically binding label able to affect the signal of the unbound...
8956824 Methods for identifying allosteric modulators of ship polypeptides  
This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide...
8956857 Three-component biosensors for detecting macromolecules and other analytes  
The invention generally provides three-component molecular biosensors. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
8956811 Diagnosis of malignant neoplasms using anti-Notch3 antibodies  
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present...
8956880 Detection of micro-organisms  
The present invention concerns methods for detecting the presence of a micro-organism in a fluid, gaseous and solid samples, together with apparatus for use in same. The invention comprises the...
8951739 Biomarker for depression, method for measuring a biomarker for depression, computer program, and recording medium  
Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the...
8951749 Enhanced immunoassay sensor  
Disclosed herein are devices for detecting the presence of a target analyte in a fluid sample. The biosensor device can comprise at least a reaction chamber and a detection chamber. The device can...
8951741 Diagnosis of Strongylus vulgaris  
Embodiments of the presently-disclosed subject matter provide an isolated polypeptide comprising the sequence of SEQ ID NO: 1, fragments thereof, and/or epitopes thereof. Embodiments of the...
8951744 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8951723 Serological screening for HHV-8 infection using antigen mixtures  
The invention provides compositions, methods, and kits for the diagnosis or detection of active, latent, or prior infection with human herpesvirus 8 in a subject sample.
8951737 Treatment and diagnosis of cancer  
Use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate specific membrane antigen (PSMA) or bind to...
8951740 Genotoxicity as a biomarker for inflammation  
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An...
8951940 Solid-phase clonal amplification and related methods  
The present invention provides methods and compositions for analyzing nucleic acid sequences. In some aspects, the methods utilize clonal objects, such as DNA balls, that have been captured on...
8951738 CYBP as a marker for lung cancer  
The present invention relates to the assessment of lung cancer. It discloses the use of protein CYBP in the assessment of lung cancer. It also relates to a method for assessing lung cancer in...
8945943 Personal glucose meters for detection and quantification of a broad range of analytes  
A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal...
8946389 Compositions and methods for multiplex biomarker profiling  
Provided herein are compositions and methods for identifying or quantitating one or more analytes in sample. The composition can comprise an affinity molecule reversibly conjugated to a label...
8945857 Methods of isolating cells and generating monoclonal antibodies  
The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of...
8945861 Methods for isotopically labeling biomolecules using mammalian cell-free extracts  
Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced...
8945854 Methods and compositions for biomarkers of fatigue  
The present invention provides methods and compositions for identifying fatigue, disease states associated with fatigue, recovery from fatigue and/or physical performance capability in a subject.
8945832 Treatment prediction involving HMGCR  
The present invention provides a method for determining whether a mammalian subject having a breast cancer is likely to benefit from an endocrine treatment, comprising the steps of: providing a...
8945480 Apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique  
The invention provides an apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique. In conventional biochemical testing, reagents need to...
8945486 Microwell device  
A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and...
8945827 Serological methods and diagnostic tests for syphilis antibodies  
A non-treponemal diagnostic test for syphilis infection includes initially dissolving cholesterol in an organic solvent and further diluting the dissolved cholesterol in an ethanol solution...
8945852 Method for electrochemical detection of binding reactions  
A method for performing homogeneous immunoassay formats with electrochemical detection in solution includes combining two different conjugates as reagents with a sample or a sample/buffer mixture,...
8945828 Method of identifying fetal antigens or cell surface markers using phage display technology  
The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognizing foetal cells. The methods of the invention may further be...
8945856 Affinity-based detection of biological targets  
A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at...
8947516 High-resolution 3D imaging of single semiconductor nanocrystals  
A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying...
8945913 Kits, compositions and methods for detecting a biological condition  
The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one...
8946169 SPARC and methods of use thereof  
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying...