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8709730 Methods of preventing and treating viral infections by inhibiting the deISGylation activity of OTU domain-containing viral proteins  
Viruses having an impaired ability to deISGylate ISG15 conjugates, in particular, viral mutants comprising a mutation in the viral genome that reduces or eliminates the ability of the viral OTU...
8709735 β-2 microglobulin as a biomarker for peripheral artery disease  
The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
8709714 Laminar library screen  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
8709354 Methods of making a diagnostic device by interweaving hydrophobic and hydrophilic fibers, and diagnostic device therefrom  
In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline...
8709715 Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof  
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes...
8709997 Prevention and treatment of osteoarthritis  
Subjects lacking Nfat1 display osteoarthritis in weight-bearing joints. Osteoarthritic changes associated with Nfat1 deficiency are characterized by articular cartilage degradation, articular...
8703129 Antibodies against extended type 1 chain antigens, derivatives thereof and use  
Disclosed herein are antibodies or antigen-binding portions thereof directed against extended Type I chain antigens, in particular extended Type I chain glycosphingolipids, and the uses of the...
8703426 Composition exhibiting a von Willebrand Factor (vWF) protease activity with the amino acid sequence AAGGILHLELLV  
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes...
8703413 Detection of human somatic cell reprogramming  
The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits...
8703432 Recombinant Treponema spp. proteins for use in vaccine, antibodies against said proteins, and diagnostic and therapeutic methods including the same  
The present invention relates to proteins and/or fragments and derivatives thereof and their use as vaccines and in biotechnological methods. The vaccines particularly include immunogenic proteins...
8703427 Biological materials and uses thereof  
The invention provides a compound comprising a photosensitizing agent coupled to a carrier molecule with a minimum coupling ratio of 3:1 wherein the carrier molecule has a binding specificity for...
8703430 Method for measuring human megalin  
This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can...
8702939 Electrotaxis methods and devices  
A method of controlling nematode response in a microfluidic environment is provided comprising exposing the nematode to an electric field that induces a nematode response. In one embodiment, a...
8703431 Polypeptides for the in vitro assessment of the sensitising potential of a test compound  
The invention relates to novel polypeptides and to the use thereof for the in vitro assessment of the sensitizing potential of a test compound, to a method for the in vitro assessment of the...
8703433 Marker for amyotrophic lateral sclerosis, and use thereof  
An object is to provide a biomarker specific to amyotrophic lateral sclerosis and a use thereof. Provided are a marker for amyotrophic lateral sclerosis containing a transmembrane glycoprotein...
8703434 Device and method for isolating biological or chemical targets  
The present invention relates to a device for collecting and concentrating biological or chemical targets with a view to detecting same, wherein the device comprises a reaction chamber (1) in...
8703428 Single-cell label-free assay  
The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution...
8703417 Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest  
The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an...
8703494 Systems and methods for determining the percentage of glycated hemoglobin  
Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.
8703429 Composition exhibiting a von Willebrand Factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV  
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes...
8703441 Monoclonal antibodies against PCBP-1 antigens, and uses therefor  
The present invention provides and includes monoclonal antibodies (MoAbs or mAbs) specific or preferentially selective for PCBP-1 antigens, hybridoma lines that secrete these PCBP-1 antibodies or...
8703435 Peptide biomarkers of cardiovascular disease  
The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a...
8703918 Isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen, conjugates and uses thereof  
An isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen (PSMA) preferably in its native form on the surface of tumour cells. A conjugate of the antibody with...
8703061 Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette  
The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an...
8703654 Identifying antigen clusters for monitoring a global state of an immune system  
Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of...
8697355 Methods and compositions for determining the purity of chemically synthesized nucleic acids  
This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which...
8697373 Reagents and methods for use in cancer diagnosis, classification and therapy  
Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen...
8697370 Biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof  
Methods for the diagnosis, prognosis and prediction of sepsis in a subject using the expression levels of the biomarkers Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) and TREM-like...
8697067 Methods for increasing the effectiveness of antibodies and/or FCY receptor-binding active ingredients  
The present invention relates to an ex vivo method for increasing the effectiveness of antibodies and Fcγ receptor-binding active ingredients, comprising the steps of: a) preparing a blood sample...
8697367 Markers for detection of complications resulting from in utero encounters  
Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus,...
8697356 Single-molecule-format probe and utilization thereof  
A single-chain probe of the present invention for detecting a ligand, comprises: a ligand binding protein for binding the ligand; a recognition protein for recognizing that the ligand is bound by...
8696567 Assay for positioning a feeding tube and method thereof  
The present invention discloses a bedside or point of care assay for properly positioning a feeding tube in the stomach of a patient based on detecting the presence of a hydrolytic enzyme found in...
8697366 Anti-cancer drug screening method using RORα  
The present invention relates to a method for screening an anticancer agent using RORα, the method comprising the steps of: culturing cells; bringing a potential substance into contact with the...
8697348 Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571  
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic...
8697365 Non-denaturing lysis reagent  
The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting...
8697005 Assemblies for multiplex assays  
Multiplex binding assay assemblies are disclosed. The assemblies include at least one assay bar that has a top side, a bottom side, and at least one well accessible from the top side of the assay...
8697368 Diagnostic marker for lung cancer comprising HPαR as active ingredient  
Disclosed is a diagnostic marker for lung cancer comprising HpαR as an active ingredient. Because blood, which is relatively easy to sample, is employed as a specimen, the diagnostic kit and...
8691595 Method for detecting analytes  
The subject of this invention is a process for detection of analytes from biological samples comprising the following process steps: a) Preparation of a reversible binding partner 1 that is...
8691513 Methods of use for an immunoassay detecting fragment Ba  
Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient,...
8691591 Self-encoding sensor with microspheres  
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
8691500 Device and method for detecting biomolecule  
Disclosed are a method for detecting a biomolecule including: immobilizing a nucleic acid aptamer capable of specifically binding to a biomolecule to be detected on the surface of a bead on which...
8691585 Methods for predicting pregnancy outcome in a subject by hCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8691151 Opto-fluidic architecture for particle manipulation and sorting  
This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to...
8691512 Method for the detection of sepsis by determining peptide prohormone levels  
Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers...
8685754 Droplet actuator devices and methods for immunoassays and washing  
Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead...
8685653 Method for stable gene-amplification in a bacterial host cell  
A bacterial host cell is disclosed including at least two copies of an amplification unit in its genome, the amplification unit including: i) at least one copy of a gene of interest, and ii) an...
8685781 Secondary treatment of films of colloidal quantum dots for optoelectronics and devices produced thereby  
A method of forming an optoelectronic device. The method includes providing a deposition surface and contacting the deposition surface with a ligand exchange chemical and contacting the deposition...
8685656 Methods for diagnosing and treating encephalitis or epilepsy  
This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of...
8685666 ARL-1 specific antibodies and uses thereof  
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
8685746 Sample preparation container and method  
A system and method for preparing and analyzing samples. The system can include a sample preparation system and a sample detection system coupled to the sample preparation system. The sample...