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8728748 HMGB1 and anti-HMGB1 antibodies for the prognostic of neurological disorders  
The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid...
8728821 Transgenic photosynthetic microorganisms  
Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms...
8728730 Methods for treating, diagnosing, and monitoring rheumatoid arthritis  
Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective...
8728829 Compositions for binding to assay substrata and methods of using  
Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for...
8728739 RBM3 in colorectal cancer prognostics  
The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of...
8722051 Tweak receptor  
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening...
8722339 Immunoassay methods  
The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid...
8722349 Methods and kit for endometriosis screening  
Methods of screening a bodily sample for endometriosis are provided. The bodily sample is preferably saliva. According to one embodied method, the bodily sample is subjected to a denaturing...
8722340 JAB1 as a prognostic marker and a therapeutic target for human cancer  
Methods of diagnosing and prognosticating the development of human cancers, such as breast cancer, colon cancer, and pancreatic cancer, are provided. The diagnostic and prognostic methods include...
8722061 Antibody profiles characteristic of tuberculosis state  
Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination of at least three M. tuberculosis protein antigens, at least one for which a...
8722343 Methods and compositions for the diagnosis and treatment of diabetes  
Methods, assays and compositions for the diagnosis and treatment of diabetes, in which the glutamate transporters and/or receptors expressed in pancreatic islet cells are used as therapeutic...
8722342 Method for enhancing sensitivity or method for avoiding influence of hemoglobin in immunological measurement  
A method for enhancing measurement sensitivity or avoiding hemoglobin influence in a latex agglutination or metal agglutination immunoassay method of a target antigen in a biological sample that...
8722341 Metapneumovirus strains and their use in vaccine formulations and sequences  
Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or...
8722344 Risk markers for cardiovascular disease  
Provided herein methods for determining whether a subject, particularly a human subject, is at risk of developing, having, or experiencing a complication of cardiovascular disease, and methods of...
8722351 Diagnostic tests for abnormal ovarian conditions  
Methods and compositions, and a kit for diagnosing ovarian disorders including autoimmunity and ovarian cancer. Ovarian autoimmunity is associated with unexplained infertility or idiopathic...
8722583 Method for selecting a chemical entity from a tagged library  
Disclosed is a method for determining the identity of a chemical entity having a preselected property. The chemical entity is identified from a library composed of a plurality of different...
8722346 Chemiluminescence compact imaging scanner  
Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars...
8722350 Methods and compositions for categorizing patients  
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and...
8722345 Methods for measuring protein content  
A process for measuring the amount of an antigen in a sample comprising the steps of binding the antigen to a solid phase, forming an antigen-antibody immunocomplex on the solid phase by applying...
8722866 Isoform-selective inhibitors and activators of PDE3 cyclic nucleotide phosphodiesterases  
The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or...
8715951 Highly sensitive immunoassays and antibodies for detection of blood factor VIII  
Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about...
8715933 Assay methods using nicking endonucleases  
Assay methods and apparatus for the analysis of biopolymers are disclosed. The assays employ nicking endonucleases to enable the generation of flaps on target biomolecules which are detected in...
8715943 Methods for improving inflammatory bowel disease diagnosis  
The present invention provides methods and systems to predict and diagnose inflammatory bowel disease (IBD) and subtypes such as ulcerative colitis (UC) and Crohn's disease (CD) by detecting the...
8715948 Granzyme A and granzyme B diagnostics  
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include...
8716441 Ubiquitin binding polypeptides  
The invention relates to Tandem Ubiquitin Affinity Entities (TUBES) which are fusion polypeptides comprising at least two ubiquitin binding domains connected to each other by non-naturally...
8715922 Virus causing respiratory tract illness in susceptible mammals  
The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the subfamily Pneumovirinae of the...
8716191 Method of preparing an adduct  
A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is...
8716233 NOTCH mutations leading to increased receptor signaling  
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with...
8715940 Method of making recombinant influenza virus  
The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the...
8716031 Method for quantification of antigen-specific canine IgE  
Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which...
8715655 Human anti-α9 integrin antibody  
The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their...
8715942 Methods for the detection of glycated hemoglobin  
Provided herein are methods for detecting glycated hemoglobin in, for example, human whole blood, that are not affected by the presence of variation in amino acid sequence that can exist in...
8715670 Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same  
The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the...
8715941 Antibodies to LRP6  
Anti-LRP6 antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. These anti-LRP6...
8715679 Pili from Mycobacterium tuberculosis  
The present invention relates to pili obtained from Mycobacterium tuberculosis, methods of producing the pili and the use of the pili for inducing an immune response against Mycobacterium...
8715667 Methods of treating patients having TLR3-positive cancer  
The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to TLR3 cell receptors present on the surface of cells. The invention also relates...
8716453 Cystatin C, β2 microglobulin, α1 microglobulin and genes for same, antibody, and kit and method for diagnosis of feline nephropathy  
Proteins respectively having the amino acid sequences represented by SEQ ID NOs: 1, 17 and 32; structural genes respectively encoding the proteins, preferably respectively having the nucleotide...
8709791 Detection of bioagents using a shear horizontal surface acoustic wave biosensor  
A biosensor combining the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral...
8709792 Lateral flow test kit and method for detecting an analyte  
A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method...
8709733 Methods for diagnosing irritable bowel syndrome  
The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the...
8709722 Methods for detecting DNA-binding proteins  
There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a...
8710193 Antibody recognizing turn structure in amyloid β  
Provided is a therapeutic method exclusively targeting an amyloid β protein (Aβ) having a specific turn structure of Aβ. Specifically provided is an antibody which specifically recognizes an...
8709731 DKK1 oncogene as therapeutic target for cancer and a diagnosing marker  
Described herein are antibodies and antibody fragments capable of treating or preventing cancers associated with the over-expression and/or up-regulation of DKK1. Also disclosed are methods of...
8709710 Methods of modulating interleukin-22 and immune response by notch regulators  
The invention relates to the use of notch regulators for modulating IL-22 production in T-cells, by influencing the activity or activation of the notch signal path. The invention further relates...
8709789 Methods and devices for rapid and specific detection of multiple proteins  
A method is provided for detecting multiple analytes via their interactions with reagents. The analytes are immobilized on an analyte support and are divided into subdivisions by a blotting...
8709732 Biomarkers of gastric cancer and use thereof  
A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression...
8709734 Method for identifying modulators of GPCR GPR1 function  
The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of...
8709429 Markers of acute myeloid leukemia stem cells  
Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and...
8709224 Methods for the detection of biologically relevant molecules and their interaction characteristics  
Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings,...
8709826 Analyte assaying by means of immunochromatography with lateral migration  
The invention relates to a device for determining an analyte in a liquid sample. The inventive device consists of: a capillary action means, involving lateral migration, defining a reference...