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8748574 Biomarker for psychiatric diseases including cognitive impairment and methods for detecting psychiatric diseases including cognitive impairment using the biomarkers  
Methods are provided that detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence. Novel...
8748105 Method for selecting a candidate drug compound  
The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two...
8748193 Apparatus for desorption and ionization of analytes  
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
8747910 Prediction of response to platinum-based therapy  
Method for determining whether a mammalian subject having a cancer belongs to a first or a second group, wherein subjects of the first group are more likely to respond to a platinum-based therapy...
8748107 Isolated antibodies which bind to CXC chemokine receptor 4  
The present invention provides antibodies which bind to CXC chemokine receptor 4 (CXCR4) and which do not induce significant apoptosis of CXCR4 expressing cells. Also provided are inter alia...
8748116 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8748106 Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II  
This application is based, inter alia, on the discovery of a binding interaction between the Hn-33 hemagglutinin polypeptide of the type A Clostridium botulinum neurotoxin complex and synaptosomal...
8748109 Method for the detection of organ or tissue injury  
This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for...
8741559 Cellular assay employing detectable protein  
Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a...
8741581 Markers for cancer detection  
The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting...
8741584 Follistatin-like protein-1 as a biomarker for inflammatory disorders  
The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated...
8741586 Antibodies against HER2 truncated variant CTF-611  
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the...
8741287 PlGF-1 assay and kits and components thereof  
The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of...
8741573 Consensus coding sequences of human breast and colorectal cancers  
Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the...
8741577 Surface immobilised multilayer structure of vesicles  
A surface-immobilized multilayer structure of a plurality of vesicles (2), the structure comprising at least one linker (4) immobilized onto the surface, the at least one linker (4) being bound to...
8741663 Enhanced detection sensitivity with piezoelectric sensors  
A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's...
8741610 Yeast mutant and substance production method using the same  
The present invention provides, inter alia, an improvement in the production of a desired product from yeast, wherein the growth rate and fermentation rate of the yeast are maintained at excellent...
8741582 Detection of a specific DEK isoform as a urine-based biomarker for bladder cancer  
The present invention is directed to a method of detecting a DEK protein isoform 2 in a human urine sample using ELISA. Methods and compositions for detection of DEK isoform 2 in human urine are...
8742336 Bio-chip for secondary ion mass spectroscopy and method of fabricating the same  
There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary...
8741585 Electronic methods for the detection of analytes  
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
8741580 Markers of renal transplant rejection and renal damage  
The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said...
8741579 Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair  
The present invention provides methods and compositions which modulate beta 1 integrin activity by functioning as allosteric antagonists. In particular, the present invention provides methods for...
8741583 Method of identifying compounds that inhibit fertilization  
A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and...
8741813 Composition, device and associated method  
A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a...
8741578 Methods of detecting chronic lymphocytic leukemia with Hsp90 and ZAP-70  
Provided are compositions and methods useful for treating and diagnosing cell proliferative disorders associated with Hsp90 and/or ZAP-70.
8741587 ARMET as a marker for cancer  
Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of...
8741576 Heteroclitic analogs and related methods  
Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are...
8741588 Monoclonal antibodies against PBP2A derived from MRSA and methods of use  
Mouse monoclonal antibodies specifically recognizing the Penicillin Binding Protein 2a (PBP2a) derived from a strain of Methicillin-Resistant Staphylococcus aureus (MRSA) were produced and...
8741630 Methods of detecting targets on an array  
The invention relates to methods of detecting a target analyte in a biological sample using composite microsphere arrays having first and second assay locations. Preferred target analytes include...
8735077 FET-type biosensor with surface modification  
Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface...
8735146 Chimeric binding peptide library screening method  
There is described a method of isolating nucleotide sequences encoding target peptides from DNA libraries using DNA binding proteins to link the peptide to the sequence which encodes it. DNA...
8735078 Apolipoprotein AII assay method for the in vitro diagnosis of colorectal cancer  
The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Apolipoprotein AII tumor marker in a biological sample taken from a...
8735564 Fast results hybrid capture assay and system  
The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
8734769 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8735173 Multiplex screening for lysosomal storage disorders (LSDS)  
A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of...
8735080 Methods and devices for detecting obstructive uropathy and associated disorders  
Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing,...
8735092 Glucose-induced inactivation/degradation-resistant transporter gene and use thereof  
The present invention relates to a glucose-induced inactivation- or degradation-resistant transporter gene and use thereof, and more particularly, to a brewing yeast having excellent assimilation...
8735079 Method for risk stratification in stable coronary artery disease  
An in vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, is disclosed wherein the concentration of procalcitonin is...
8735061 Biomarkers of cancer metastasis  
There is provided a method for determining tumour metastatic potential using biomarkers of tumour metastasis comprising any two of carbonic anhydrase-9 (CAIX), vascular endothelial growth factor C...
8735648 Model system of Acanthamoeba keratitis syndrome and method for selecting a treatment thereof  
Methods for generating a feline model for ocular complications arising from amoeba infection are described. The invention further relates to screening methods for therapeutics for the treatment of...
8735062 Chemiluminescence proximity nucleic acid assay  
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a sample and the methods of use thereof. The detection system includes a...
8728744 Salivary protein biomarkers for human oral cancer  
The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a...
8728828 Purification of immunoglobulins  
The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilized, wherein the ligand density is in the range of...
8728741 Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof  
The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound...
8728740 Monoclonal antibody and its use for the identification of the oncofetal isoform of fibronectin (B-FN) for diagnosis or therapy  
Epitopes localized on FNIII-8 repeat that are normally cryptic but are unmasked by insertion of FNIII-B into the FN molecule and are recognized by specific ligands are described; antibodies or...
8729239 Antibodies against fatty acid synthase  
The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their...
8728747 Alteration of cell membrane for new functions  
Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene...
8728980 Peptide microarray and method of use  
A peptide microarray comprising a plurality of predicted unique binding peptides being selected by computational prediction of interaction with a protein of interest or a domain thereof. The...
8728783 Photobioreactor  
Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms...
8728742 Methods predicting risk of an adverse clinical outcome  
Provided are methods for evaluating the risk of an adverse clinical outcome in a subject, deciding whether to discharge or continue treating a subject (e.g., on an inpatient basis), or to initiate...