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8765386 Oral fluid rapid assay for hepatitis C virus (HCV) antibodies using non-antibody labeling of IgA molecules recognizing HCV peptide epitopes  
A method and device to detect Hepatitis C (HCV) antibodies in oral fluid is provided. This method introduces a non-antibody detection molecule that labels all classes of patient antibodies in oral...
8765458 Coated sensors and methods related thereto  
The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent...
8765373 Sensor and method for detection of a target substance  
A method of detecting a target substance includes providing a number of molecular tethers at a channel surface of a sensor such that at least some of a plurality of beads, as a result of a...
8765476 Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing  
Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed...
8765384 Carbohydrate-ligand conjugates and their application for the analysis of carbohydrate-protein interaction  
A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a...
8765393 Endotoxin-binding ligands and their use  
An affinity ligand-matrix conjugate of the structure Z-Spacer-[NX-A]m-NY-A-NK2 is useful for the isolation, separation, purification, characterization, identification or quantification of...
8765422 D4 desaturases and D5 elongases  
Disclosed are methods and compositions related to ONC-T18, D4-desaturases, D5 elongases, their isolation, characterization, production, identification, and use for fatty acid production, as well...
8765643 Composition, device and associated method  
The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first...
8765387 Method of diagnosing Sjogren's disease  
Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of...
8765077 Reagent dispensers and stackable bars for multiplex binding assays  
Multiplex binding assay assemblies are disclosed. The assemblies generally include at least one assay bar that includes a top side, a bottom side, and at least one well accessible from the top...
8765117 Generation of vascularized human heart tissue and uses thereof  
The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized...
8765376 Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator  
The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of...
8765385 Method of detection of neutralizing anti-actriib antibodies  
The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.
8765389 Genetic products which are differentially expressed in tumors and use thereof  
The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. The invention also relates to the therapy and...
8759013 Dual-target biosensor cell assays  
A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.
8759114 Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit  
Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.
8759004 Compounds and methods for detection of carcinomas and their precursor lesions  
The present invention relates to compounds and methods for detection and treatment of carcinomas and their precursor lesions. The invention provides DNase nucleic acids and polypeptides useful for...
8758993 Systems and methods for predicting response to anti-androgen therapy for the treatment of androgenetic alopecia  
Methods, processes, systems, and apparatuses are disclosed for predicting anti-androgen therapy response in the treatment of androgenetic alopecia based on a fluorometric assay and proteomics.
8759009 Anti-alpha2 integrin antibodies and their uses  
The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain of α2 integrin and inhibit the interaction of α2β1 integrin with...
8759005 Tissue carbohydrate compositions and analysis thereof  
The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and...
8759010 Host cell kinases as targets for antiviral therapies against HCV infection  
The present invention provides several networks of cellular protein kinases as potential targets for medical intervention against hepatitis C virus (HCV) infection and HCV-related diseases and...
8762068 Methods for threshold determination in multiplexed assays  
Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function...
8759007 Method to produce a receptor chip using biotinylated protein  
The present invention provides a method for detecting modified LDL, abnormal cells or bacteria using an intermolecular interaction analysis method, in which a region involved in ligand recognition...
8758994 CDK9 as modifier of the IGF pathway and methods of use  
Human CDK9 genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF,...
8759012 Method of determining dose and administration of statin  
The object of the present invention is to provide a method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease. The object is achieved by...
8758727 Site specific fluorescence and contrast marker for same  
A contrast marker for indicating a presence of a target cell in an environment comprises a fluorophore, an NMP, and a short spacer and a long spacer linking the fluorophore to the NMP. The short...
8759006 PSCA: prostate stem cell antigen and distinguishing androgen receptor negative prostate cancer from benign prostatic hyperplasia  
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high...
8759018 Method for determining treatment of disseminated intravascular coagulation  
A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura...
8759109 Use of female mammal's urine for determination of fetal gender related characteristics  
The present invention provides a method for determining the gender of a fetus by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the...
8759011 Assay system for determining binding of hydrophobic drugs  
The invention comprises a method for the determination of the binding coefficient of a hydrophobic chemical compound comprising: g. Providing an assay plate with a plurality of rows and columns of...
8759008 Robust, self-assembled, biocompatible films  
The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a...
8758772 Peptides and methods for the detection of lyme disease antibodies  
The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences...
8753872 Method and apparatus for assay for multiple analytes  
A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each...
8753870 Device for detecting and separating target molecules and method for detecting and separating target molecules by using the same  
A device, system, and method for detecting or separating target molecules allowing efficient detection even when only a small amount of target molecules or target cells are included in a sample...
8753824 Serial multiple antigen colocalization in paraffin-embedded tissue  
The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single...
8753836 Dewaxing buffer containing a water-soluble organic solvent and methods of use thereof  
Dewaxing buffers containing a water-soluble organic solvent, methods for use thereof, and kits incorporating dewaxing buffers. The dewaxing buffers contain a water soluble organic solvent that has...
8753829 Monoclonal antibodies against HER2 antigens, and uses therefor  
The present invention provides and includes monoclonal antibodies (mAbs) preferentially selective for HER2 antigens, hybridoma lines that secrete these HER2 antibodies or antibody fragments, and...
8753823 Immunoassay method for detecting the presence of antibodies to intravenously injected oral medications  
The steps of the method are preparing a specific antigen; intravenously injecting prescription medication initially intended for oral consumption into the blood stream of the patient, the...
8753822 Neoepitope detection of disease using protein arrays  
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of...
8753825 Methods and kits for detecting ITA in a biological sample  
Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect...
8753826 Methods of detecting factor D with anti-factor D antibodies  
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the...
8753623 Influenza vaccine  
The present invention discloses isolated peptides encoding an antigen or fragments thereof from the N-terminus of hemagglutinin protein of influenza, methods for isolating such antigens and...
8753893 Multi-dimensional fluid sensors and related detectors and methods  
The present invention provides multi-dimensional sensors with fluidic flow channels for processing fluid samples.
8753641 Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy  
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of...
8753627 Anti-activin a antibodies and uses thereof  
The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human,...
8748110 Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy  
Methods of treating a subject having a cardiovascular disease, selecting a therapy for a subject having a cardiovascular disease, identifying a subject having a cardiovascular disease that will...
8748108 Biomarkers for identifying patient classes  
Disclosed are methods for classifying a patient with cancer as a candidate for therapy with a Bcl-2 family inhibitor comprising determining the level of at least one biomarker in a sample and...
8748097 Identification of agents for treating calcium disorders and uses thereof  
The present invention provides systems for identifying genes and gene products associated with nitrogenous bisphosphonate treatment (NBP) treatment of calcium disorders. The invention also...
8748114 ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL)  
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is...
8748195 Molecular markers for urinary tract infections  
The invention relates to an in vitro method for determining procalcitonin levels in plasma and urine as a diagnostic marker to identify patients with urinary tract infections, in vitro methods to...