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8785135 Mutant G-protein coupled receptors and methods for selecting them  
The present invention relates in some aspects to mutant G protein coupled receptors (GPCRs) and methods for selecting those with increased stability. In certain aspects, the invention relates to...
8785138 Monovalent ligands of the human CD28 receptor  
The invention relates to monovalent ligands of the human CD28 receptor, which can selectively block the interaction between CD28 and B7 without activating the CD28 receptor. Said ligands can be...
8785137 Method for renal disease diagnosis using Rab23 as marker  
Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.
8785123 Direct hierarchical assembly of nanoparticles  
The present invention provides hierarchical assemblies of a block copolymer, a bifunctional linking compound and a nanoparticle. The block copolymers form one micro-domain and the nanoparticles...
8785143 Method for immobilizing streptavidin on a self-assembled monolayer  
Provided are a method for increasing an amount of streptavidin to be immobilized on the self-assembled monolayer and a sensor which comprises streptavidin immobilized with the method. The method...
8785391 Compound and method for treatment of alzheimer's disease and familial dementia  
An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal,...
8785120 Method for the treatment of a sample containing biomolecules  
The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid...
8785134 Glycoprotein vesicles and their methods of use  
Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least...
8784838 H3 influenza A virus  
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
8785136 Immunodetection probe and method of immunodetection using the same  
An immunodetection probe comprises a needle structure having a compartment and configured to be inserted into an organic tissue, a dialysis membrane configured to isolate the compartment from the...
8785139 Modification-dependent activity assays  
Disclosed herein are methods, systems and kits to measure the presence and/or activity of recombinant polypeptides comprising a modification.
8788714 Method for synchronizing execution of multiple processing devices and related system  
A system includes multiple processing devices. Each processing device is configured to receive first and second status flags from first and second neighboring processing devices, respectively....
8785150 Quantifiable internal reference standards for immunohistochemistry and uses thereof  
Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.
8784929 Bilayers  
A method for producing a bilayer of amphipathic molecules comprising providing a hydrated support and providing a hydrophilic body, and bringing the hydrated support and hydrophilic body into...
8778624 Zwitterion-containing acridinium compounds  
Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like,...
8778615 Methods and compositions for diagnosis and prognosis of renal injury and renal failure  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal...
8778612 Method for quantitatively determining a number of analytes  
A method for the quantitative assay of n different analytes, where n is at least 2, is provided. The method consists of the following steps: (a) At least one labeled detector-binding partner is...
8778647 Methods of producing isoprene comprising a membrane bioreactor  
The invention provides improved methods for the production of isoprene from biological materials using a membrane bioreactor to culture isoprene-producing cells.
8778614 Assays for detecting modified compounds  
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or...
8778618 Compositions and methods for characterizing a myopathy  
The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
8778699 Detection of degradation products of canine NT-proBNP  
A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits...
8778347 Fluorescent neutralization and adherence inhibition assays  
The present invention comprises rugged, inexpensive, reliable, and sensitive laboratory assays of antibody-based viral neutralization activity and antibody-based viral adherence inhibition...
8778617 Method for determining the binding constant of high affinity compounds  
The invention relates to a method for determining the binding constant of a compound of interest to proteins comprising the following steps: a) adding the high affinity compound to a two-chamber...
8778697 Method of measuring the affinity of biomolecules  
The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length...
8778667 Method and unit for detection of interactions of biologically relevant molecules  
The present invention relates to a unit to be used for detection of interactions of biologically relevant molecules using a carrier on which the biologically relevant molecules are immobilized,...
8778616 Method of using CCR3 binding agents to detect choroidal neovascularization  
The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither...
8778619 Oxidized cardiolipin and uses to detect cardiolipin antibodies  
Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may...
8778606 At-home cancer test  
The at home cancer test permits a layperson to qualitatively test for the presence of carcinoma in the privacy of their home. The test includes a test strip coated or impregnated with at least one...
8778846 Composition, device and associated method  
A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the...
8779088 Vaccine for the treatment of Mycobacterium related disorders  
The invention relates to genes and proteins involved in the sporulation of Mycobacteria and the use thereof in the technical fields of immunology and medicine. A vaccine comprising spore forming...
8778613 Affinity resin  
A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are...
8771967 Immunomodulation of functional T cell assays for diagnosis of infectious or autoimmune disorders  
Improved assays for detecting the presence of a specific cell-mediated immune response in an individual are provided, where a sample comprising T cells and other cells of the immune system,...
8771962 Health test for a broad spectrum of health problems  
Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for...
8772049 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8771964 Compositions and methods for detection of methadone metabolite  
Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly (amino acid) label...
8771971 Methods and kits for measurement of lymphocyte function  
The present invention provides simple and rapid methods for measuring the function of a desired subset of lymphocytes, for example, T cells, B cells or NK cells. In addition, the present invention...
8771693 Methods and compositions for the generation and use of conformation-specific antibodies  
The present invention features methods and compositions for the generation and use of conformation-specific anti-bodies or fragments thereof.
8772448 Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis  
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis....
8771960 Method for producing protein libraries and for selecting proteins from said libraries  
The invention relates to a method for the production of a protein library, in particular an antibody library, which is highly diverse and for the selection of proteins, in particular antibodies,...
8772047 Dyes having ratiometric fluorescence response for detecting metabolites  
The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When...
8771972 Clozapine immunoassay  
Novel conjugates and immunogens derived from clozapine and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of clozapine in biological fluids.
8771966 Immuno-PET imaging of antibodies and immunoconjugates and uses therefor  
Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the...
8771963 Method of diagnosing esophageal cancer  
In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray...
8771969 Peptide antibody depletion and its application to mass spectrometry sample preparation  
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant...
8772243 Methods for predicting the response to anti-cancer treatment with an agonist of TLR7 or an agonist of TLR8  
The present invention relates to methods for predicting the response to treatment with an agonist of TLR7, or an agonist of TLR8 or an anti-cancer agent for treating cancer, in particular...
8771961 Monitoring myocardial infarction and its treatment  
Disclosed is a method of determining which medication is to be applied in a remodeling process of a subject after a myocardial infarction, the method comprising determining an amount of a...
8771965 Methods and compositions involving nucleotide repeat disorders  
The present invention concerns the methods and compositions involving nucleic acids with long repeat sequences. In some embodiments of the invention, there are methods for generating such a...
8772042 Biomarkers for diagnosing alzheimer's disease  
A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies...
8771991 SOAT polypeptide reaction mixture  
The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.
8771968 Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...