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8815542 Unnatural reactive amino acid genetic code additions  
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
8815520 Method for discrimination of metaplasias from neoplastic or preneoplastic lesions  
The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level...
8815517 Methods for identifying functionally related genes and drug targets  
The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described....
8815526 Methods and reagents for identifying/isolating T regulatory (Treg) cells and for treating individuals  
An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an...
8815519 Method for predicting cancer and other diseases  
The invention concerns a marker for low-grade inflammation and metabolic syndrome (MS) and MS-related diseases and/or low-grade inflammation-related diseases such as cardiovasculardisease,...
8815518 Kit for detection/quantification of analyte, and method for detection/quantification of analyte  
Disclosed are a detection/quantification kit and a detection/quantification method for detecting/quantifying an analyte rapidly at a low cost and in a simple manner. Specifically, disclosed is a...
8815525 Binding and functional assays that use the T1R3 receptor to screen for taste modulatory compounds  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
8812241 Method for normalizing clinical laboratory measurements  
A computerized method for normalizing the results of clinical laboratory tests to a reference scale includes providing a measured value of a clinically significant parameter, providing a set of...
8808626 Amperometric immunosensor  
An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an...
8808998 Diagnostic method for atherosclerosis  
The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible...
8809004 Detection of feline immunodeficiency virus  
Method, device and kit for the detection of antibodies directed to Feline Immunodeficiency Virus (FIV). The method includes contacting the felid biological sample with FIV env polypeptide and...
8808997 Lung cancer markers, and uses thereof  
Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM)....
8809027 Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase  
Microorganism compositions are described that comprise combinations of genetic modifications that include a genetic modification to increase oxaloacetate alpha-decarboxylase enzymatic activity. By...
8808985 Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm  
The present invention discloses certain genetic variants as susceptibility variants for peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA). The invention relates to risk...
8808666 Peptides that specifically target amyloid deposits  
The present invention provides a novel method of detecting amyloids in a subject. The present invention provides peptides that bind selectively to amyloids and are useful for detecting amyloids...
8809016 Nucleic acids encoding modified vitamin K-dependent polypeptides  
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
8802428 Method of detecting microorganisms and microorganism detecting apparatus  
It is possible to determine the presence of bacteria in a sample solution in a shorter period of time without changing a conventional incubating method. Bacteria in a sample solution are incubated...
8802381 Methods for predicting pregnancy outcome in a subject by HCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8802376 Methods for identifying candidate cytotoxic antibody molecules  
The disclosure relates to methods for screening candidate antibody molecules which bind to podocalyxin-like protein (PODXL) and/or to undifferentiated pluripotent stem cells and particularly,...
8802383 Monoclonal antibodies and uses thereof  
The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods...
8802382 Cobalamin assay  
The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the...
8802448 Mixed mode ligands  
Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of...
8802378 Potency test for vaccine formulations  
The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test...
8802024 Biochip and manufacturing method thereof  
A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first...
8802380 Method for testing or screening protein synthesis inhibitors  
This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus....
8802375 Methods for characterizing antibody binding affinity and epitope diversity in food allergy  
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects,...
8802025 Reagent kit for sample analysis and sample analysis method  
The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second...
8802450 Fluorescent methods and materials for directed biomarker signal amplification  
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be...
8802449 Microchips, kits, and methods for immunoassays  
An objective of the present invention is to provide immunoassay microchips in which microstructures of beads having a sufficient reaction area were constructed within microchannels while...
8802446 Method for measuring cystatin C in human body fluid  
Provided is a method and reagent for measuring cystatin C in a human body fluid, by contacting a human body fluid with (a) first insoluble carrier particles coated with a first anti-human cystatin...
8795974 Anti-LG3 antibodies and uses thereof  
A method for the prediction of the risk and/or the diagnosis of vascular damage such as acute vascular rejection in a subject, based on the determination of anti-LG3 antibodies levels in a sample...
8795975 Methods and compositions for diagnosis and risk prediction in heart failure  
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention...
8795143 Spinning force apparatus  
A spinning force system and methods of operation are provided for measuring a characteristic of a sample. The system includes a detection module having a light source for illuminating the sample...
8796184 Detection assay devices and methods of making and using the same  
An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c)...
8796428 Erk1/2 posphorylation site specific antibody  
The invention relates to an antibody specific to Erk1/2 phosphorylated at Thr188 and a method for producing the same. The invention also relates to an in vitro method for determining the presence...
8795981 Cell detection  
In one aspect the present invention provides a method of identifying a cell or cell colony which produces a polypeptide of interest, the method comprising exposing one or more cells to a marker...
8796014 Method for producing tissue cells from pluripotent stem cells derived from iris pigment epithelial cells of animal and tissue cell obtained by method  
A method for producing tissue cells derived from iris pigmented epithelial cells of an animal, and tissue cells obtained by the method are provided. The method and the tissue cells solve problems...
8796039 Method for measuring inhibitory activity on ligand-receptor binding  
A method for measuring the presence or absence and/or strength of the inhibitory activity of a test substance on binding between a ligand and a receptor thereof, which comprises the following...
8795973 Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof  
This disclosure is directed to methods and compositions to inhibit MASP protein activity using small molecule inhibitors. In one aspect, the disclosure is directed to methods for identifying...
8795979 Hydrolase enzyme substrates and uses thereof  
The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions...
8795963 Genetic markers for risk management of atrial fibrillation and stroke  
The invention relates to procedures and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or...
8795999 Immunoadsorption of anti-von Willebrand factor cleaving protease antibodies  
This invention relates to adsorbents and methods for highly selective removal of anti-von Willebrand Factor-cleaving protease antibodies (“anti-vWF-cp-abs”) from human plasma using human von...
8796040 System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination  
A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target...
8790882 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8790881 Method for measuring IgG-mediated complement activation  
A method for measuring immunoglobulin G-mediated complement activation, includes the following steps: a) preparing a sample A of immunoglobulin G and a sample B including natural serum, the...
8790885 Coagulogen raw material, process for producing the same, and method and apparatus for measuring physiologically active substance of biological origin using the same  
Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL...
8790880 Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile  
Accurate and fast detection of the presence of Clostridium difficile (C. difficile) disease is crucial for the proper treatment of patients with C. difficile infection. Present tests detecting the...
8790665 Serum protein-based detection of random sequence polymer compositions  
There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual...
8790651 Interleukin-31 monoclonal antibody  
An isolated antibody that specifically binds to at least one of canine Interleukin-31 (IL-31) or feline IL-31 is provided. Such antibodies can be in the form of diagnostic and/or veterinary...
8785145 Method for diagnosing gram-negative infections  
The invention concerns an in vitro method for determining if an individual is infected by a gram-negative bacterium preferably on prosthesis comprising: (i) detection of antibodies directed...