|
Match
|
Document |
Document Title |
|
|
7351549 |
Method for the manufacture of recombinant trypsin
The present invention relates to a method for the manufacture and purification of recombinant trypsinogen and trypsin in E. coli and yeast, using high yield expression vectors with and without...
|
|
|
7270979 |
DNA for expression of alpha 1-antitrypsin in methylotropic yeast
Alpha 1-antitrypsin is prepared by growing in a fermentor methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage...
|
|
|
7238356 |
Core-glycosylated HCV envelope proteins
The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in...
|
|
|
7202356 |
Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
The regulatory sequences (i.e., promoter regions, introns and enhancers) associated with the Yarrowia lipolytica gene encoding fructose bis-phospate aldolase (FBA1) have been found to be...
|
|
|
7198919 |
Use of alpha factor sequences in yeast expression systems
The isolation of the yeast α-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used...
|
|
|
6962796 |
Production of human parathyroid hormone from microorganisms
The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli , transformed...
|
|
|
6951734 |
Methods for producing proteins by using cell-free protein synthesis systems
A method for producing a protein suitable for X-ray crystallographic analysis, in a cell-free protein synthesis system comprising a cell-free extract, a nucleic acid coding for said protein, and...
|
|
|
6924125 |
Expression of heterologous multi-domain proteins in yeast
This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the...
|
|
|
6858409 |
Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
Compounds are disclosed having the general formula R 1 —X—R 2 , wherein R 1 and R 2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group....
|
|
|
6858384 |
Phage antibodies
Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific...
|
|
|
6828131 |
Biological fertilizer based on yeasts
The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds,...
|
|
|
6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
|
|
|
6800466 |
Biological fertilizer compositions comprising sludge
The present invention provides biological fertilizer compositions that comprise yeast cells and sludge. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen,...
|
|
|
6733997 |
Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins
A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the...
|
|
|
6730303 |
Fused G-CSF and IL-3 proteins and uses thereof
Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional...
|
|
|
6645739 |
Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
The present invention provides novel expression systems for producing desired polypeptides in certain strains of yeast. The present invention further provides methods for producing polypeptide...
|
|
|
6642029 |
Hybrid DNA synthesis of mature insulin-like growth factors
Methods and compositions are provided for efficient production of human insulin-like growth factor. Synthetic IGF I and IGF II genes are joined to leader and processing signals which provide for...
|
|
|
6596272 |
Biological fertilizer compositions comprising poultry manure
The present invention provides biological fertilizer compositions that comprise yeast cells and poultry manure. The yeast cells of the invention have an enhanced ability to fix atmospheric...
|
|
|
6562576 |
Yeast two-hybrid system and use thereof
A method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in yeast cells. The interaction between the two...
|
|
|
6551786 |
Screen assay for selecting protein-protein interaction modulators
A method for selecting compounds capable of modulating protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in the presence of...
|
|
|
6545140 |
DNA encoding an avian beta-defensin and uses thereof
An isolated nucleic acid molecule encoding avian beta-defensin is provided. Further provided are compositions comprising an avian beta-defensin, or portions thereof.
|
|
|
6534286 |
Protein production in Aureobasidium pullulans
The present disclosure provides methods and DNA molecules for the synthesis of heterologous proteins in the fungus Aureobasidium pullulans either intracellularly or with secretion out of the...
|
|
|
6509447 |
G protein chimeras and methods of screening compounds
A chimeric G α protein having yeast G α (Gpa1p) amino acid sequences modified by a minimum of 3 amino acids positions within the C-terminal 10 amino acids by substitution by alternative amino...
|
|
|
6503749 |
Yeast strains possessing the interrupted ATF2 gene and their applications
A subject of the invention is a modified yeast strain in which the acetyl-CoA pregnenolone acetyltransferase (APAT) activity is eliminated by altering the gene coding for this activity with...
|
|
|
6479735 |
Transgenic plants including a transgene consisting of a hybrid nucleic acid sequence, comprising at least one unedited mitochondrial gene fragment from higher plants and process for producing them
Hybrid nucleic acid sequences including at least the coding region of an unedited mitochondrial gene of superior plants and controlling the male fertility of plants containing said sequences,...
|
|
|
6458527 |
HIV immunoassays using gag polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
|
|
|
6306625 |
Method for obtaining expression of mixed polypeptide particles in yeast
The present invention provides a method for obtaining expression of a mixed hepatitis B surface antigen particle, e.g., a particle of mixed polypeptide composition, in yeast. Also disclosed is a...
|
|
|
6303319 |
Cell based assay for identifying sh2-domain-specific signal transducer antagonist
The present invention provides methods and compositions for identifying inhibitors of the interaction between phosphopeptide binding pairs, i.e., a protein domain having at least one phosphopeptide...
|
|
|
RE37343 |
Expression and secretion of heterologous proteins in yeast employing truncated alpha-factor leader sequences
A yeast α-factor expression system is provided comprised of a truncated leader sequence, containing the α-factor signal peptide and one glycosylation site, linked by a processing site to a...
|
|
|
6277631 |
Recombinant proteins with the immunoreactivity of hepatitis B virus e antigen (HBeAg), a process for the preparation thereof and the use thereof in immunoassays and vaccines
Recombinant yeast expression vectors with the features indicated in the patent claims are described. These recombinant yeast expression vectors can be used for the preparation of HBeAg in yeast...
|
|
|
6274148 |
Hepatitis C virus asialoglycoproteins
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal...
|
|
|
6214547 |
Synthetic leader peptide sequences
The present invention relates to synthetic leader peptide sequences for secreting polypeptides in yeast.
|
|
|
6183989 |
Process for making desired polypeptides in yeast
The invention describes a process for making desired polypeptides in yeast. The desired products are expressed as leader bound polypeptides connected by means of a monobasic processing site. The...
|
|
|
6171828 |
Method for culturing microorganisms having a methanol metabolic pathway
The present invention discloses a method for culturing microorganisms having a methanol metabolic pathway in which an expression unit is introduced that comprises a target gene linked downstream...
|
|
|
6169171 |
Hybrid protein between CS from plasmodium and HBSAG
Isolated DNA sequences encoding a novel hybrid protein are provided which comprise a portion of the CS protein of P. falciparum and the surface antigen of Hepatitis B virus. Vectors and host cells...
|
|
|
6121513 |
Sulfonamide resistance in plants
Recombinant proteins comprising on or more mitochondrial leader peptide sequences and a domain having herbicidal sulfonamide-insensitive dihydropteroate synthase activity are disclosed....
|
|
|
6114147 |
Immobilized proteins with specific binding capacities and their use in processes and products
A method is provided for immobilizing a binding protein capable of binding to a specific compound, using recombinant DNA techniques for producing said binding protein or a functional part thereof....
|
|
|
6083717 |
Upstream activator sequences and recombinant promoter sequences functional in yarrowia and vectors containing them
The invention concerns an upstream activating sequence (UAS) functional in Yarrowia consisting essentially of at least one copy of a selected sequence, and an recombinant promoter sequence...
|
|
|
6068995 |
Method for producing protein
A method for producing a desired protein, which comprises growing, by a fed-batch culture, a host cell capable of expressing the desired protein, wherein the specific growth rate of the host cell...
|
|
|
6046000 |
Method for identifying genes encoding signal sequences
The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal...
|
|
|
6033875 |
Method of improved production of insulin-like growth factor
The present invention relates to a method of making a recombinant protein in high yields by adding alkali to a cell culture that is capable of producing recombinant protein. The recombinant protein...
|
|
|
6027910 |
Process for immobilizing enzymes to the cell wall of a microbial cell by producing a fusion protein
A method is provided for immobilizing an enzyme, comprising immobilizing the enzyme or a functional part thereof to the cell wall of a microbial cell using recombinant DNA techniques. The enzyme is...
|
|
|
5965140 |
Hybrid particle immunogens
Novel immunogenic compositions are provided involving viral particles composed at least in part of hybrid proteins of at least a portion of a particle forming protein and one or more polypeptides...
|
|
|
5958724 |
Process for producing heme proteins
The present invention relates to methods for producing heterologous heme proteins extracellularly comprising transforming a filamentous fungus with a vector comprising a DNA sequence encoding the...
|
|
|
5952195 |
Promoters for expressing proteins of interest in yeast
The present invention provides novel nucleic acid fragments isolated from the genomic DNA of yeast and having transcription promoter activity, as well as expression cassettes, vectors, and host...
|
|
|
5874255 |
DNA encoding humanized antibodies specific for the ganglioside GM.sub.2
Chimeric human antibody expression vectors are constructed by inserting the antibody heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from...
|
|
|
5866374 |
Gene conferring flocculating property on yeast and gene product thereof
A protein designated "Lg-Flo1" can be produced recombinantly and confers brewer's yeast-type flocculating property, for example, when Lg-FLO1 DNA is expressed in non-flocculent yeast strain....
|
|
|
5853739 |
Transmission-blocking vaccine against malaria
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells...
|
|
|
5814484 |
Expression of macrophage inducible proteins (MIPS) in yeast cells
Methods for the expression of mammalian MIP-1α and MIP-1β are disclosed. The methods generally comprise introducing into a yeast cell, a DNA molecule capable of directing the expression and if...
|
|
|
5756313 |
Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
A plasmid for a yeast host, the plasmid comprising in sequence: (1) a yeast derived promoter, (2) an albumin-encoding region placed under control of the yeast-derived promoter, (3) a transcription...
|