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7358067 |
Fermentation method for production of heterologous gene products in lactic acid bacteria
The invention provides a fed-batch or continuous process for producing heterologous peptides, polypeptides or proteins in lactic acid bacteria, comprising the steps of (i) constructing a...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7314913 |
PRO1891 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7297551 |
Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
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7252972 |
Methods for secretory production of proteins
The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete...
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7247455 |
Streptococcus pyogenes DNase B leader peptide and methods for its use
The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the...
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7235712 |
Bacterial isolates of the genus Klebiella, and an isomaltulose synthase gene isolated therefrom
Two strains of a novel bacterial species, Klebsiella singaporensis LX3 and LX21, are claimed. A nucleotide sequence (kis) encoding a novel form of isomaltulose synthase, KIS, is also claimed....
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7220830 |
Polypeptide underexpressed in stomach tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7202338 |
PRO731 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7202335 |
PRO300 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7196167 |
Polypeptide underexpressed in lung tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7196166 |
Secreted polypeptide overexpressed in rectal tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7193047 |
Polypeptide encoded by a nucleic acid underexpressed in esophageal tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7193046 |
Polypeptide encoded by a nucleic acid overexpressed in esophageal and lung tumor, and underexpressesd in kidney tumor and melanoma
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7189532 |
Nucleic acid underexpressed in stomach tumor and lung tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7144998 |
Clostridium perfringens beta-2 toxin signal sequence, promoter and recombinant prokarote host cells comprising them
Recombinant polypeptides are prepared using novel nucleic acids with transcription promoter activity. The recombinant cells containing said nucleic acids are described. A novel method for preparing...
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7141582 |
Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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7125679 |
Methods to screen peptide libraries using minicell display
A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process....
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7122354 |
Nucleic acid encoding a chimeric polypeptide
DNA molecules comprising a sequence encoding the signal peptide of hGH linked to a heterologous protein and related cells, methods and fusion proteins.
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7119262 |
Production of transgenic poinsettia
Since its introduction into North America over 170 years ago, the poinsettia has become a major ornamental potted plant, and is an important component of the U.S. floral industry. Susceptibility to...
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7105349 |
Selective plant growth using d-amino acids
This invention relates to plants and plant cells which express heterologous D-amino acid metabolizing enzymes and may therefore employ D-amino acids as a source of nitrogen. Methods and means are...
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7102057 |
Self-processing plants and plant parts
The invention provides polynucleotides, preferably synthetic polynucleotides, which encode processing enzymes that are optimized for expression in plants. The polynucleotides encode mesophilic,...
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7098383 |
Methods for the production of multimeric immunoglobulins, and related compositions
Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobulins, in association with oil bodies are described. The redox protein is enzymatically...
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7091401 |
Expression of epidermal growth factor in plant seeds
The present invention provides a method of preparing epidermal growth factors in plants and transgenic plant seeds containing epidermal growth factors. The method provides an economical way to...
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7049483 |
Transgenic bioluminescent plants
Transgenic plants are created having incorporated into them a luciferase enzyme gene and a corresponding luciferin substrate gene. These genes are regulated such that for a certain amount of time...
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7037684 |
Process for producing polypeptide having disulfide bond
The invention relates to a DNA that enables co-expression of a protein disulfide isomerase and a polypeptide having disulfide bonds. The invention further relates to a process of producing...
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6962796 |
Production of human parathyroid hormone from microorganisms
The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli , transformed...
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6958235 |
Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19)...
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6936256 |
Sub-unit vaccine for infectious pancreatic necrosis virus
The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty...
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6924125 |
Expression of heterologous multi-domain proteins in yeast
This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the...
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6902911 |
Human 2-19 protein homologue z219C
The present invention relates to polynucleotide and polypeptide molecules for z219c, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be...
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6890748 |
Production of lysosomal enzymes in plants by transient expression
The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and...
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6875590 |
Leader peptides for enhancing secretion of recombinant protein from a host cell
Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides...
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6866998 |
Cellular assays for identifying signaling peptides
The invention includes a DNA encoding a known translocatable protein, for example, human mpl, lacking secretory ability due to deletion of its secretory signal and the major part of the...
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6855513 |
Quorum sensing signaling in bacteria
The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention...
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6852507 |
Recombinant baculovirus and use thereof in the production of monoclonal antibodies
Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first...
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6846969 |
Process for the production of plants with enhanced growth characteristics
The invention is drawn to plant cell transformation with a nucleic acid construct comprising a prokaryotic ammonium-specific asparagine synthetase, type A, coding sequence, operably linked to a...
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6846667 |
Virulence genes and proteins, and their use
The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The...
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6833491 |
Modification of polysaccharides
The present invention relates to a method for manufacturing modified polysaccharide in contact with a sugar group transferring enzyme and a sugar group donor. The result of the method is modified...
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6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
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6806351 |
Secreted protein HBJFE12
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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6791011 |
Protein complementation in transgenic plants
The invention relates to pairs of parent plants for producing hybrid seeds and to methods for producing plants with a desired phenotype. The desired phenotype is an active enzyme, a regulatory...
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6781034 |
Stress tolerant plants
The present invention relates to the finding that the accumulation of flavodoxin within chloroplasts of plant cells provides enhanced resistance to sources of environmental stress, including...
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6761882 |
Helical cytokine zalpha33
Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID...
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6759209 |
Bacillus strain and assay methods
Micro-organisms having a chromosome in which at least one gene has been partly or wholly replaced by a homologous gene from another micro-organism, and an artificially introduced reporter gene is...
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6753462 |
Transgenic plants with increased calcium stores
The present invention provides transgenic plants over-expressing a transgene encoding a calcium-binding protein or peptide (CaBP). Preferably, the CaBP is a calcium storage protein and...
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6753167 |
Preparation of heterologous proteins on oil bodies
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
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6750046 |
Preparation of thioredoxin and thioredoxin reductase proteins on oil bodies
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
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6737563 |
Transgenic seeds expressing amylopullulanase and uses therefor
The invention provides DNA constructs and genetically engineered seeds for the expression of amylopullulanase in plant seeds such as rice seeds. Related methods are also provided for the production...
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6733997 |
Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins
A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the...
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