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7390639 |
Staphylococcal nuclease fusion proteins for the production of recombinant peptides
Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier...
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7388089 |
Anti-arthropod vector vaccines method of selecting and uses thereof
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent...
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7384913 |
PT32 sperm protein, sperm c-Yes, oocyte cytoplasmic c-Yes, and uses thereof
The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of...
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7384768 |
Nucleic acids and polypeptides specific for pathogenic strains of the Neisseria genus
The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
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7384638 |
Compounds and methods for treatment and diagnosis of Chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia ...
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7381572 |
Reagents and procedures for multi-label high-specificity labeling
A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material;...
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7381544 |
Nucleic acid that encodes a fusion protein
This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a...
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7378512 |
Production of proteins by autoproteolytic cleavage
The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is...
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7378492 |
CD40-related receptor that binds CD40L
Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also...
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7378275 |
Canine IL-13 receptor alpha-1 subunit nucleic acid molecules
The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7371817 |
PRO9783 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7371816 |
PRO10284 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7365171 |
Chemokine-like factors (CKLFs) with chemotactic and hematopoietic stimulating activities
The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a...
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7365162 |
Stabilized bioactive peptides and methods of identification, synthesis, and use
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system,...
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7361487 |
Enzyme fusion proteins and their use
Cellulase fusion proteins comprising an endoglucanase core region and a heterologous cellulose binding domain are described. The fusion proteins may be produced by recombinant techniques using...
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7358074 |
Human phosphatase RET31, and variants thereof
The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant...
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7351796 |
PRO9904 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7351794 |
PRO1754 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7351549 |
Method for the manufacture of recombinant trypsin
The present invention relates to a method for the manufacture and purification of recombinant trypsinogen and trypsin in E. coli and yeast, using high yield expression vectors with and without...
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7348151 |
Method for the cellular high-throughput-detection of nuclear receptor ligand interactions
The invention relates to fusion proteins comprising at least three domains, where
a first domain facilitates membrane localization of the fusion protein in a cellular context, and a second...
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7347995 |
Compositions and methods for achieving immune suppression
Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient.
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7344860 |
Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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7344719 |
Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family...
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7343721 |
PRO4406 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7342096 |
PRO1879 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7341722 |
Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
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7339031 |
Modified bouganin proteins, cytotoxins and methods and uses thereof
The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The...
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7338930 |
Methods of treating osteoarthritis using IL-17 receptor proteins in combination with TNF-receptor proteins
Methods for regulating levels of nitric oxide are disclosed. The methods utilize IL-17 receptors, which may be used in conjunction with inhibitor of IL-1 and/or TNF.
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7338786 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7338766 |
Compositions and methods for treating malaria with cupredoxin and cytochrome
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the...
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7335733 |
Tissue cement proteins from Rhipicephalus appendiculatus
The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful...
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7335729 |
PRO4320 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7335728 |
PRO1310 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7335370 |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia , specifically C. pneumoniae . The method involves nucleic acid...
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7332303 |
Product quality enhancement in mammalian cell culture processes for protein production
The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to,...
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7326682 |
Conotoxin peptides
The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such...
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7326548 |
Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors,...
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7326543 |
Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
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7326530 |
Method for localizing polypeptide on cell surface
The present invention relates to a polypeptide having an activity for targeting a heterogeneous polypeptide to a surface of cytoplasmic membrane, a nucleic acid encoding the polypeptide, a...
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7323545 |
PRO1885 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7323544 |
PRO1434 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7319144 |
Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen...
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7319135 |
PRO1341 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7317086 |
Basal cell carcinoma tumor suppressor protein
This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7314913 |
PRO1891 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7314864 |
Humanin, a polypeptide suppressing neuronal death
The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease...
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7314725 |
Phenylthiocarbamide (PTC) taste receptor
The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste...
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7314626 |
Use of peptide vectors to improve the immune response to antigens
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups...
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