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7387873 |
Human myeloma cell line
There is provided a human myeloma cell tine for use in a method for producing a human monoclonal antibody.
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7381798 |
Recombinant antibody recognizing dioxin and gene encoding the antibody
The present invention relates to a novel recombinant antibody having a binding activity to 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF), a gene encoding its amino acid sequence, a vector...
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7381560 |
Expression and use of anti-CD20 antibodies
Disclosed are immunologically active antibodies directed against the CD20 antigen, as well as host cells comprising nucleic acid sequences encoding the light chains and heavy chains of...
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7361341 |
Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other...
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7354999 |
PRO1481 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7342110 |
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced...
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7339033 |
PRO1481
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7335748 |
RG1 antibodies and uses thereof
The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
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7335634 |
Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers
Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers prevents a bleeding diathesis and reduces pre-, peri- and postoperative blood loss in...
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7332582 |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
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7323311 |
Methods of obtaining a specific binding member that binds eotaxin
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The...
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7321026 |
Framework-patched immunoglobulins
Framework (FR)-patching is a novel approach to modify immunoglobulin for reducing potential immunogenicity without significant alterations in specificity and affinity. Unlike previous described...
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7319139 |
TAG-72 specific CH2 domain deleted antibodies
Methods, compositions and kits comprising dimeric antibodies for the treatment of neoplastic, autoimmune or other disorders are provided. The dimeric antibodies of the instant invention may...
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7314615 |
IκB Kinase-β (IKKβ) binding antibodies and methods of using same
The present invention provides an isolated nucleic acid molecules encoding IκB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that...
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7306907 |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying...
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7291721 |
Anti-IL-6 antibodies, compositions, methods and uses
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at...
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7291479 |
Method for detecting the von Willebrand factor-cleaving protease activity of ADAMTS-13
The invention relates to a diagnostic method for determining the von Willebrand factor (VWF) cleaving activity of ADAMTS-13 in a test medium during which the test medium is mixed with 0.5 to 5 U/ml...
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7285379 |
Artificial oxygen carrier and production method thereof
The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a...
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7282199 |
Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of...
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7279560 |
Antibody fragments to JTT-1 protein and cells secreting such antibody fragments
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
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7273727 |
Fusion proteins for prodrug activation
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity...
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7271145 |
Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
The present invention relates to blood products, and more particularly to compositions comprising a modified hemoglobin in plasma.
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7261890 |
Methods for using canine immunoglobulin variable domains and caninized antibodies
The present invention provides canine heavy chain and light chain (both λ and κ) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised...
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7258998 |
Cell culture medium
A method for culturing cells in the presence of an alcanoic acid for enhancing protein production.
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7256273 |
Humanized antibodies that recognize beta amyloid peptide
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.
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7253263 |
Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of antibody against ganglioside GD3
The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to “GD3”), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and...
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7250503 |
Nucleic acid molecules encoding clot-specific streptokinase fusion proteins possessing altered plasminogen activation characteristics
The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of...
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7250494 |
Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and...
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7247453 |
Calcium binding recombinant antibody against protein C
A Ca 2+ dependent recombinant antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C has been constructed. The...
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7244592 |
Ligand screening and discovery
Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second...
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7238785 |
RS7 antibodies
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more...
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7227002 |
Human antibodies that bind human 17-A1/EpCAM tumor antigen
The present invention provides an anti-human antibody or fragment thereof that is low or not immunogenic in humans. In particular, the antibodies or fragments are directed to human tumor antigens,...
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7223561 |
Process of high purity albumin production
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers...
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7217798 |
Alteration of Fc-fusion protein serum half-lives by mutagenesis
The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250,...
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7214514 |
Identification of human cell lines for the production of human proteins by endogenous gene activation
A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form...
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7202048 |
Onset of force development as a marker of thrombin generation
Platelet contractile force (PCF) is used as a surrogate marker of thrombin generation. PCF generation occurs concomitant with the burst of prothrombin fragment F 1+2 release. The time between assay...
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7198919 |
Use of alpha factor sequences in yeast expression systems
The isolation of the yeast α-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used...
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RE39548 |
Interleukin-5 specific recombinant antibodies
An effective anti-IL-5 recombinant antibody molecule comprising heavy and/or light chain antigen-binding residues from a donor antibody.
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7196175 |
Antibodies to JTT-1 protein and cells secreting such antibodies
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
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7192714 |
LDL receptor signaling assays
The invention provides methods and compositions for modeling and detecting LDL receptor transmembrane signaling by detecting proteolysis of an LDL receptor transmembrane domain. The method...
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7189825 |
Cancerous disease modifying antibodies
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer...
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7189824 |
Tumor vessel endothelial cell-binding monoclonal antibodies
A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing the monoclonal antibody,...
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7189820 |
Antibodies against tumor necrosis factor delta (APRIL)
The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and...
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7189397 |
Cytotoxicity mediation of cells evidencing surface expression of CD44
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease...
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7186820 |
Production of humanised antibodies to TNFα
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein...
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7186529 |
Preparation of erythropoietin by endogenous gene activation
The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a...
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7183388 |
Anti-MUC-1 single chain antibodies for tumor targeting
This invention provides novel antibodies that specifically bind to the cancer antigen MUC-1. The antibodies are useful targeting moieties for specifically directing imaging agents and various...
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7183108 |
Selection and uses of lactic acid bacteria strains modulating non-specific immunity
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
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7179595 |
Compositions and methods for generating antigen-binding units
The present invention provides non-single-chain antigen-binding units that is stabilized by leucine zipper sequences. The experimental design is particularly useful for generating and screening for...
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7175996 |
Methods of optimizing antibody variable region binding affinity
The present invention relates to compositions and methods of producing higher affinity molecules, and in particular, higher affinity antibodies. Specifically, the invention contemplates methods of...
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