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6696276 |
Vasopermeability-enhancing conjugates
Liposomal conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to...
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6649375 |
Adenoviral vectors for enhanced gene expression
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount...
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6642028 |
Vectors and genes exhibiting increased expression
Novel genes and vectors exhibiting increased expression and novel splicing patterns are disclosed. The gene can comprise one or more consensus or near consensus splice sites which have been...
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6638752 |
Biodetectors targeted to specific ligands
The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a...
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6635478 |
Production of recombinant proteins using herpes virus promoters and VP16 transactivators
Stable cell lines are produced to express high levels of a gene product of interest using VP16, a herpes simplex virus transactivator, and a promoter from herpes simplex virus which is a target for...
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6627193 |
Methods and compositions for control of blood coagulation
Methods for controlling blood coagulation, and suitable pharmaceutical compositions that include a polypeptide that enhances the anticoagulation process (or inhibitors thereof for reversing the...
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6623940 |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector...
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6620587 |
Ribosome complexes as selection particles for in vitro display and evolution of proteins
The invention provides a method of displaying nascent proteins or peptides as complexes with eukaryotic ribosomes and the mRNA encoding the protein or peptide following transcription and...
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6617133 |
Process for purifying recombinant human serum albumin
The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution...
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6610295 |
Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor
HCMV glycoproteins B and H have been identified. The gB protein is encoded by DNA in the HindIII F fragment of the HCMV genome lying between 1378 and 4095 bases from the F/D boundary. The gH...
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6602503 |
Recombinant anti-VLA-4 antibody molecules
The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
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6579688 |
Stabilizing diluent for polypeptides and antigens
Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be...
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6573071 |
Factor X analogues with a modified protease cleavage site
Factor X analogues having a modification in the region of the natural Factor Xa activation cleavage site, said modification representing a processing site of a protease not naturally cleaving in...
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6570061 |
Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice
Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with...
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6569430 |
Antibodies to the antigen Campath-1
An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be...
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6562599 |
Single-stranded antibody against hepatitis B virus core protein, gene thereof, and therapeutic agent for hepatitis B containing these
A DNA characterized by coding for a single-stranded antibody capable of binding to a hepatitis B virus core protein: a single-stranded antibody coding for the DNA: a therapeutic agent for hepatitis...
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6562598 |
Factor X deletion mutants and analogues thereof
Factor XΔ analogues are provided, as well as pharmaceutical preparations containing such analogues and methods of preparing such analogues. The factor XΔ analogues have a deletion of the amino...
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6555373 |
Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of...
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6548640 |
Altered antibodies
The invention relates to altered antibodies that have a heavy or light chain variable domain in which the framework regions differ from the framework regions naturally associated with the...
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6541225 |
Methods and compositions for generating human monoclonal antibodies
The present invention provides a method for generating human monoclonal antibodies, especially those that are specific for surface antigens representative of a particular cell type. The present...
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6537762 |
Peptide mimotope to mycotoxin deoxynivalenol and uses thereof
The present invention provides a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody...
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6531298 |
Factor IX antihemophilic factor with increased clotting activity
A non-naturally occuring Factor IX protein having an amino acid substitution at amino acid position 338 is provided. Preferred substitutions include the substitution of analanine, leucine, or...
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6521230 |
CD25 binding molecules
Monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or...
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6514730 |
Secretion of hirudin derivatives
A process for obtaining hirudin derivatives from E. coli secretor mutants which entails: (1) construction of a recombinant vector on which there is located the gene coding for a hirudin...
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6509171 |
Aspartic proteinase deficient filamentous fungi
This invention relates to novel mutant filamentous fungi which are deficient in the gene for the corresponding aspartic proteinase. These organisms are useful production hosts in the production of...
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6500646 |
Cell membrane-directed drugs
Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the...
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6489290 |
Antiplatelet agent
This invention combines the unique antiplatelet effects of S-nitrosothiols and the antiadhesive properties of fragments of von Willebrand (vWF) in the A1 domain to provide unique molecules that...
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6485943 |
Method for altering antibody light chain interactions
A method for recombinant antibody subunit dimerization including modifying at least one codon of a nucleic acid sequence to replace an amino acid occurring naturally in the antibody with a charged...
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6471500 |
Process for producing erythropoietin containing no animal proteins
A process for producing erythropoietin which is free of foreign animal proteins except for the proteins of the host cell, wherein DNA coding for EPO is expressed in a eukaryotic host cell and the...
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6461824 |
Production of chimeric antibodies with specificity to human tumor antigens
The invention is directed to chimeric immunoglobulins that recognize a human tumor antigen bound by antibody, ING-2, ING-3, ING-4 or KM10, the production of such chimeric immunoglobulins, and their...
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6458360 |
Soluble complement regulatory molecules
This invention is directed to a soluble recombinant fused protein which is stable in the mammalian circulatory system comprising a polypeptide which contains a recognition site for a target...
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6451980 |
Signal enhancement of bispecific antibody-polymer probe for immunoassay use
An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a...
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6451982 |
Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy...
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6428967 |
LDL receptor signaling pathways
The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction...
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6416758 |
Antibody conjugate kits for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6410269 |
Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
Vitamin D-binding protein (Gc protein) and its small domain (approximately ⅕ of the Gc peptide also known as domain III) were cloned via a baculovirus vector. The cloned Gc protein and the cloned...
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RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector...
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6410270 |
Process for the preparation of recombinant proteins in E. coli by high cell density fermentation
The invention relates to a fed-batch fermentation process which uses special E. coli host/vector systems for the purpose of efficiently forming recombinant proteins, in particular recombinant...
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6407213 |
Method for making humanized antibodies
Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are...
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6395515 |
Directed switch-mediated DNA recombination
Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S 1 ), and 2) a target locus minimally...
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6368810 |
Glutathione S-transferase homolog
The invention provides a human glutathione S-transferase (GSTH) and polynucleotides which identify and encode GSTH. The invention also provides expression vectors, host cells, agonists, antibodies...
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6358703 |
Expression system for factor VIII
This invention describes a protein-free production process for proteins having factor VIII procoagulant activity. The process includes the derivation of stable human cell clones with high...
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6344596 |
Expression of active human factor IX in mammary tissue and of milk non human transgenic mammals
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present...
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6337193 |
Expression of manose-binding protein in methylotrophic yeast
Expression of Mannose-Binding Protein in methylotrophic yeast strains is disclosed.
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6331415 |
Methods of producing immunoglobulins, vectors and transformed host cells for use therein
The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and...
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6329176 |
Method for the production of factor VII
Disclosed is a method for high efficiency release of recombinant proteins in eukaryotic cells and more specifically, for enhancing the secretion of Factor VII by co-expression of kex2 endoprotease...
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6319690 |
Preparation and use of gene banks of human antibodies ("human-antibody libraries")
The invention relates to the preparation and use of gene banks of human antibodies (Ab). Starting from a mixture of human B-lymphocytes, their mRNA is translated into the cDNA using oligo-dT...
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6316227 |
Nucleic acids encoding interleukin-5 specific recombinant antibodies
An effective anti-IL-5 recombinant antibody molecule comprising heavy and/or light chain antigen-binding residues from a donor antibody.
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6312693 |
Antibodies against human CD40
The Applicants have discovered humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating...
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6291161 |
Method for tapping the immunological repertiore
The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by...
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