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7374912 Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof  
Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone...
7374911 Interleukin-1 related gene and protein  
Disclosed in an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules...
7364724 Recombinant super-compound interferon  
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor...
7351555 Mouse cytokine receptor Zcytor16  
Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as “mouse...
7347995 Compositions and methods for achieving immune suppression  
Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient.
7341851 IL-8 like protein  
This present invention relates to a novel protein, termed INSP085, herein identified as an IL-8 like protein and to the use of this protein and nucleic acid sequence from the encoding genes in the...
7285273 Method for down-regulating IL5 activity  
Improvements in therapy and prevention of conditions characterized by an elevated level of eosinophil leukocytes, i.e. conditions such as asthma and other chronic allergic diseases are disclosed. A...
7258997 Methods of increasing protein expression levels  
The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline....
RE39788 Gene therapy  
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
7252967 Nucleic acids encoding cytokine-like proteins that promote cell proliferation  
A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by...
7250276 Human IL-1 epsilon DNA and polypeptides  
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
7235637 IL-1 eta DNA and polypeptides  
The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms...
7217540 Polynucleotide encoding IL-1 zeta, TDZ.1 isoform polypeptide  
The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of...
7189813 PRO1338 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7186528 Method for preparing a physiologically active IL-18 polypeptide  
A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease.
7183108 Selection and uses of lactic acid bacteria strains modulating non-specific immunity  
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
7160861 Methods of inducing IL-10 production  
The invention provides a method of inducing IL-10 production.
7141651 Multiple cytokine protein complexes  
The invention relates to protein complexes and fusion proteins including at least two different cytokine molecules. The protein complexes and fusion proteins may further include a targeting moiety...
7141392 Latent fusion protein  
The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent...
7141390 Polynucleotide encoding human interleukin-17 receptor like molecule  
The application relates to a newly identified polynucleotide, polypeptide encoded by such polynucleotide, the use of such polynucleotide and polypeptide, as well as the production of such...
7122352 Polynucleotide encoding mammalian cytokine-like polypeptide-10  
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
7119191 Polynucleotide encoding mammalian cytokine-like polypeptide-10  
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto 10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
7115398 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host...
7109002 Viral interleukin-6  
The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and...
7105653 IL-2 selective agonists and antagonists  
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
RE39270 Process for continuous optimized protein production in insect larvae  
The present invention provides for a recombinant insect larvae and a process of manufacturing proteins utilizing insect larvae that allows for the selection of individual larvae for harvest at the...
7052686 Pegylated interleukin-10  
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The...
RE39015 DNA encoding interleukin-B30  
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
7005501 Purified mammalian cytokines; related reagents and methods  
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
6998476 Nucleic acids encoding antagonists of interleukin-15  
Disclosure herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
6955807 IL-2 selective agonists and antagonists  
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
6936440 Selecting ligand agonists and antagonists  
We have discovered that growth hormones from ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to...
6927043 Interleukin-2 mutein expressed from mammalian cells  
Glycosylated interleukin-2 muteins are described. A method of producing the muteins using mammalian cells is included. The muteins may be incorporated into pharmaceutical preparations useful for,...
6891086 Plastid transformation of Brassica  
A method is provided for transforming Brassica plants to express DNA sequences of interest from the plant cell plastid. The method allows the transformation of Brassica plant tissue with...
6884603 Nucleic acids encoding IL13 mutants  
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13...
6843987 Mammalian cytokines; receptors; related reagents and methods  
Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
6825334 Peptides of IL-2 and derivatives thereof and their use as therapeutic agents  
The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
6808902 Process for correction of a disulfide misfold in IL-1ra FC fusion molecules  
The present invention concerns a process by which a misfold in an Fc fusion molecule can be prevented or corrected. In one embodiment, the process comprises (a) preparing a pharmacologically active...
6753167 Preparation of heterologous proteins on oil bodies  
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
6686178 Cytokine zalpha11 ligand polynucleotides  
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the...
6680380 Nucleic acids encoding mammalian interleukin-1&zgr , related reagents and methods  
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided....
6664077 DNA encoding ACPL  
The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
6656462 Interleukin-1 muteins useful as vaccine adjuvants  
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example,...
6649375 Adenoviral vectors for enhanced gene expression  
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount...
6630576 Amino acid substitution mutants of interleukin 13  
This invention provides mutant hIL13 molecules include those made by substituting one or more of the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other...
6600020 Canine interleukin 18 polypeptide  
The present invention relates to canine interleukin 18 and an interleukin 18 production method.
6596853 DNA encoding peptides of IL-2  
The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of...
6583270 Interleukin-19  
The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are...
6569645 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
6562578 IL-17-like cytokine binding compounds and antibodies  
IL-17-like cytokines from mammals, reagents and diagnostic kits related thereto including purified proteins, specific antibodies, and nucleic acids are provided. Methods of using the reagents and...
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