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5641868 |
Interlekin-6 compositions, and a production process thereof
The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid...
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5641657 |
DNA encoding an interleukin-6 splice variant
Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical...
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5641665 |
Plasmids suitable for IL-2 expression
The present invention relates to plasmids suitable for IL-2 expression, particularly, human IL-2 expression, and related methods.
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5637477 |
Recombinant protein production and insect cell culture and process
A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear...
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5635599 |
Fusion proteins comprising circularly permuted ligands
The present invention provides for circularly permuted ligands which possess specificity and binding affinity comparable to or greater than the specificity and binding affinity of the original...
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5633146 |
Method for producing recombinant proteins and host cells used therein
Novel genetically engineered yeast strains of genus Kluyveromyces lactis, their preparation, and the use thereof for producing recombinant proteins, are described.
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5633141 |
Human IL-8 receptor binding assay
The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a...
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5624823 |
DNA encoding procine interleukin-10
Purified DNA encoding porcine IL-10, porcine IL-10, and methods of inducing immunological tolerance and inhibiting graft versus host disease.
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5614185 |
Compositions containing reduced, microbially produced interleukin-2 (IL-2)
A process for recovering microbially produced IL-2 in a highly pure form from the cellular material of the microorganisms that produced it comprising: disrupting the-cell membranes of the...
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5610284 |
Method of purification of human BCDF
There are disclosed (i) a purification process for obtaining a human BCDF having the intramolecular disulfide linkage and the stereostructure of natural type human BCDF which comprises subjecting...
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5606023 |
Mutant tumor necrosis factor proteins
Mutant tumor necrosis factor proteins which retain full or near full capability to bind to a TNFR-p75 receptor while retaining only a limited capability to bind a TNFR-p55 receptor are provided....
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5602025 |
Non-tumorigenic cell lines for expression of genes
Non-tumorigenic cell lines capable of indefinite growth in serum-free media are disclosed. The cell lines are capable of expressing exogenously introduced genes, and may be derived from mouse...
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5602007 |
Recombinant DNA molecules
This invention provides a DNA sequence coding for a mammalian granulocyte macrophage colony stimulating factor (GM-CSF), a method of obtaining same, vectors and hosts harboring same. The sequence...
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RE35450 |
Soluble human interleukin-1 receptors, compositions and method of use
Soluble human Interleukin-1 receptor proteins (shuIL-1Rs) and methods of using shuIL-1Rs to suppress immune or inflamatory responses in a mammal.
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5599690 |
Control of norleucine incorporation into recombinant proteins
Norleucine incorporation into recombinant gene products may be inhibited by culturing the cells expressing the gene products in media comprising a high level of leucine and/or methionine, or by...
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5597900 |
Crystalline interleukin-4
A process for crystallizing recombinant human interleukin 4 (rhulL-4) from a solution containing a sulfate or citrate salt is described. The crystalline form is suitable for x-ray diffraction and...
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5591827 |
Interleukin-6 receptor antagonists
This invention provides a class of interleukin-6 (IL-6) muteins which act as IL-6 receptor antagonists, thereby inhibiting the normal function of naturally-occurring IL-6. These IL-6 receptor...
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5591427 |
Human Interleukin-3(Il-3) variants and their use to promote or antagonize IL-3-mediated processes
This invention relates to human IL-3 variants. The human IL-3 variants are used in pharmaceutical compositions, in methods for modulating proliferation, differentiation or functional activation of...
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5587300 |
Method to increase regulatory molecule production
The present invention provides a method to increase the production of a regulatory molecule, i.e., a molecule that regulates cell behavior, such as a cytokine or a protooncogene, in a population of...
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5587302 |
T cell growth factor
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports...
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5580755 |
Human pluripotent granulocyte colony-stimulating factor
Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of a mammalian (e.g., human) pluripotent granulocyte...
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5578710 |
Activation of recombinant proteins
A process for the activation of recombinant proteins which are present in at least a partially inactive form in which a protein is activated by known solubilization or/and renaturation techniques,...
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5574138 |
Epithelium-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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5565336 |
Carboxy terminal IL-6 muteins
This invention relates to a Carboxy Terminal IL-6 Mutein with enhanced biological activity. The invention comprises a mutein of IL-6 having increased activity wherein the mutein has an amino acid...
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5563046 |
Fusion polypeptides and proteins
The invention is directed to the use of IL-1-like fusion polypeptides to increase the solubility and activity of recombinant polypeptides. The invention includes a nucleic acid encoding a fusion...
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5556946 |
Interleukin-2/viral antigen protein chimers
Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence...
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5552304 |
CDNA Clones coding for human protein exhibiting a broad cellular activity spectrum (human interleukin-4)
Plasmid vectors are provided that carry cDNA clones coding for polypeptides exhibiting B-cell, T-cell and mast cell stimulatory activities, all of which are enhanced in the presence of other...
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5545537 |
Method of making cysteine depleted IL-6 muteins
Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51...
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5543141 |
Therapeutic methods using interleukin-3 (IL-3) human/murine hybrid polypeptides
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) in which segments of the polypeptide sequence of the human IL-3 polypeptide have been...
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5541088 |
Recombinant process of producing non-glycosylated B-cell defferentiation factor
A purified human B-cell differentiation factor (BCDF) which does not have a natural signal peptide attached to the N-terminal thereof, DNA encoding the BCDF, transformed cells containing such DNA,...
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5536657 |
Recombinant DNA encoding human receptor for interleukin-12
This invention relates to substantially pure Interleukin-12 receptor cDNAs and protein and uses therefore. The Interleukin-12 receptor is shown to be a member of the cytokine receptor superfamily...
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5530098 |
Human B-cell differentiation factor and process of producing said factor
A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the...
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5516512 |
N- and C-terminal truncation and deletion mutants of human interleukin-3
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus...
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5510462 |
IL-1βprotein precursor
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically,...
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5510472 |
Production of recombinant human interferon-beta2
Human interferon-beta 2<2unull>s and interferon-beta 2<2unull>s are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the...
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5501962 |
Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) in which segments of the polypeptide sequence of the human IL-3 polypeptide have been...
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5491076 |
Expression of foreign genes using a replicating polyprotein producing virus vector
The present invention provides an expression vector adapted for expressing heterologous proteins in plants susceptible to a polyprotein-producing plant virus. The vector utilizes the unique ability...
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5484887 |
Homogeneous interleukin 1
Interleukin 1 has been purified by use of various techniques including ion exchange chromatography and dye-ligand affinity chromatography. By these techniques, interleukin 1 has been purified to...
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5470730 |
Method for producing T.sub.H -independent cytotoxic T lymphocytes
The present invention relates to cytotoxic T lymphocytes (CTLs) which have been converted to a helper T cell independent phenotype by introducing a recombinant expression vector encoding IL-1...
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5464939 |
Highly purified protein, production and use thereof
A substantially pure non-glycosylated human interleukin-2 protein having a specific activity of not less than 10 4 U/mg is obtained by growing a transformant carrying a DNA having a base sequence...
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5463029 |
Purification of fusion proteins comprising GM-CSF and IL-3
A process for purifying a fusion protein comprising GM-CSF and IL-3 is disclosed.
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5457038 |
Natural killer stimulatory factor
A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a...
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5455330 |
Interleukin-1 antagonist and uses thereof
Medicaments that have prophylactic or therapeutic applications for the treatment of disease resulting from the production of cytokines, particularly IL-1, that effectively inhibit the biological...
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5437988 |
Expression and secretion of mature human beta interleukin-1 in Bacillus subtilis and means and methods for its achievement
A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences...
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5437986 |
Extraction of heterologous insoluble proteins from bacteria
An insoluble mammalian protein is extracted from transformed bacteria expressing the mammalian protein while avoiding irreversible insolubilization of bacterial host proteins by homogenizing the...
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5432082 |
Expression and secretion vector in yeasts, useful for preparing heterologous proteins
The invention provides an expression and secretion vector in yeasts which is useful for preparing heterologous proteins, comprising a synthetic oligonucleotide which directs the secretion of the...
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5427924 |
Gene regulation cassettes, expression vectors containing the same and microorganisms transformed with the same
The present invention relates to gene regulation cassettes useful for (1) detecting the specific mRNA sequences which best enhance the translation efficiency of mRNA into protein when a specific...
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5427927 |
Process for the enzymatic cleavage of recombinant proteins using IgA proteases
For the enzymatic cleavage of fusion proteins and for the isolation of deed components of these fusion proteins (1) a junction region, in which two components of the fusion protein are joined...
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5419899 |
Purified, reduced recombinant interleukin-2 compositions
A process for recovering microbially produced IL-2 in a highly pure form from the cellular material of the microorganisms that produced it comprising: disrupting the cell membranes of the...
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5417970 |
Drugs containing a glycosylated interleukin-2
An interleukin-2 preparation suitable for pharmaceutical purposes, consisting essentially of disialilated glycosylated interleukin-2, monosialilated glycosylated interleukin-2, or a mixture...
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