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5874561 |
DNA, host cell and vector encoding a protein with cytokine inhibitory activity
The present invention is directed to DNA, host cells and a vector encoding a protein with cytokine inhibitory activity, particularly IL-1 inhibitory activity. The protein encoded by the DNA of the...
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5874556 |
Hybrid genes for use in the production of T.sub.H -independent cytotoxic T cells
Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T-helper cells. The vectors are...
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5863769 |
DNA encoding interleukin-1 receptor antagonist (IL-1raβ)
IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides...
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5863528 |
Porcine cytokines
A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the...
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5856142 |
Method for the extraction of periplasmic proteins from prokaryotic microorganisms in the presence of arginine
The invention relates to a method for the extraction of recombinant periplasmic proteins wherein arginine is used as the extraction agent. In particular, the invention relates to a method for the...
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5856140 |
γ-chain humaninterleukin-2 receptor polypeptide and method of making
A polypeptide which specifically binds to the γ-chain of the human interleukin-2 receptor and selectively inhibits the binding of the γ-chain of human interleukin-2 receptor to the β-chain of...
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5854028 |
Compositions comprising IL-11 and methods of making and using IL-11
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
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5849283 |
Human interleukin-6 receptor antagonists
It is known that the ligands of the group of cytokines similar to Interleukin 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and...
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5847098 |
DNA encoding interleukin IL-1β mutant
A homogeneous interleukin 1β (IL-1β), its derivative having a modified amino acid sequence of IL-1β, a gene coding for said derivative, medical composition comprising said derivative as a...
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5833975 |
Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
Attenuated vaccinia or canarypox recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed...
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5831022 |
Purification of recombinant human IL-1α
A process for the production of essentially homogeneous soluble, stable, endotoxin free human recombinant interleukin-1α of enhanced specific activity is described. The process involves breaking...
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5817486 |
Recombinant human interleukin-3 (IL-3) multiple mutation polypeptides
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid...
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5792935 |
Agrobacterium tumefaciens transformation of Musa species
Methods are provided for transforming Musa plants. In particular, methods for wounding meristematic Musa plant tissue to facilitate access of Agrobacterium tumefaciens comprising...
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5789552 |
Interleukin-6 receptor antagonists
Disclosed are interleukin-6 receptor antagonists. These receptor antagonists are generated by mutating amino acid positions 31, 35, 118, 121, 175, 176 and/or 183 of human interleukin-6.
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5789539 |
Chemokine-like proteins and methods of use
The invention relates to novel chemokine-like proteins that include two or more newly discovered active domains from different chemokines. Active domains are regions of several contiguous amino...
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5776465 |
Recombinant mycobacterial vaccines
The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a...
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5772992 |
Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
The invention provides compositions comprising a human interleukin-3 (hIL-3) variant or mutant protein (mutein) and another colony stimulating factor, cytokine, lymphokine, interleukin, or...
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5773245 |
Methods for increasing secretion of overexpressed proteins
The present invention is directed to methods for increasing secretion of an overexpressed gene product present in a host cell, by inducing expression of chaperone proteins within the host cell.
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5766885 |
Potyvirus vectors for the expression of foreign genes
The present invention provides an expression vector adapted for expressing heterologous proteins in plants susceptible to a polyprotein-producing plant virus. The vector utilizes the unique ability...
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5759818 |
N-terminal CTP extended pharmaceutical peptides and proteins
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides at the aminoterminus to alter their clearance patterns. "Complete" CTP units have the amino acid...
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5756675 |
IL-1α derivatives
The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1α...
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5750172 |
Transgenic non human mammal milk
This invention relates to the production of recombinant proteins, such as coagulation factors VIII and IX, tissue plasminogen activator (TPA), urokinase, growth hormone, insulin, interferons,...
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5750376 |
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
A method for producing genetically modified neural cells comprises culturing cells derived from embryonic, juvenile, or adult mammalian neural tissue with one or more growth factors that induce...
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5738845 |
Human interferon τ proteins and methods of use
The present invention describes the production of interferon-τ proteins and polypeptides derived therefrom. The antiviral and anticellular proliferation properties of these proteins and...
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5738849 |
Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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5736387 |
Envelope fusion vectors for use in gene delivery
The invention provides retroviral vectors which can be used for directing gene delivery to a specific sub-population of mammalian cells. The vectors comprise chimeric targeting proteins which...
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5730970 |
Pharmaceutical compositions comprising human interleukin-4 (IL-4)
A pharmaceutical composition comprising human Interleukin-4 (IL-4).
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5728552 |
DNA encoding a fusion protein comprising a viral antigen and lymphokine
Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence...
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5723755 |
Large scale production of human or animal proteins using plant bioreactors
The present invention relates to an expression vector for the large scale production of a human or animal protein, which comprises a DNA construct consisting of operatively linked DNA coding for a...
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5723309 |
Production of subunits of soluble T cell receptors by co-transfection
Soluble, single chain T cell receptors, nucleic acid sequences, particularly DNA sequences, encoding the soluble, single chain T cell receptor, expression vectors containing the DNA sequences, and...
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5723117 |
Use of interleukin-1 (IL-1) to inhibit development of hepatitis
A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and...
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5723118 |
Therapeutic agents which are antagonists or partial agonists of human interleukin 4
The invention relates to therapeutic agents which are antagonists or partial agonists of human interleukin 4, or contain these antagonists or partial agonists, to mutant hIL-4 proteins and to...
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5710251 |
Purification of bacterially expressed human interleukin-10
Disclosed is a method for purifying Interleukin-10 (IL-10). The method is comprised of subjecting an IL-10 containing solution to cation exchange chromatography, anion exchange chromatography,...
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5707616 |
Method for treating or preventing gastrointestinal disease with epithelium-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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5700913 |
Unglycosylated human interleukin-2 polypeptides
Recombinant human Interleukin-2 (IL-2) polypeptides are provided. The polypeptides are produced by expression of suitable nucleic acid molecules in transformed host cells such as E. coli.
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5700664 |
Mammalian cytokine, IL-11
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
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5695965 |
Neurospora expression system
Neurospora crassa transformations are employed for production of heterologous proteins, where DNA constructs are prepared using a foreign gene under transcriptional and translational regulatory...
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5696234 |
Muteins of mammalian cytokine interleukin-13
Methods for screening for partial agonists and for antagonists of mammalian cytokines. Particular positions of natural cytokines are identified as critical in providing these receptor mediated...
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5681723 |
Mutant interleukin 6 with improved biological activity over wild interleukin 6
The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6 of...
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5681936 |
Method of purification of recombinant human interleukin-5
Disclosed is a method for purifying Human interleukin-5 (IL-5) a single chromatographic step. After removing cells from a cell culture expressing human interleukin-5, IL-5 is purified by first...
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5677149 |
Interleukin-3 (IL-3) mutant polypeptides and their recombinant production
Disclosed are recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) having one to three amino acid substitutions in the core sequence (residues 15-125) of the native (133...
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5674486 |
Cancer immunotherapy with carrier cells
A novel method of tumor immunotherapy is described comprising the genetic modification of cells resulting in the secretion of cytokine gene products to stimulate a patient's immune response to...
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5658755 |
Method for extra-cellular expression of protein
Heterologous extra-cellular expression of recombinant proteins in soluble functional form is desirable because of the ease associated with purification of the secreted proteins and avoidance of the...
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5658761 |
Stromal cell lines from human bone marrow and their use
A human bone marrow stromal cell line, which is characterized in that the cells of the cell line, after irradiation which results in the growth being arrested, remain adherent, is suitable for use...
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5656266 |
Method of using interleukin-4
Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the...
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5652123 |
Protein having interleukin 13 activity, recombinant DNA coding for this protein, transformed cells and microorganisms
The subject of the present invention is a protein having cytokine type activity, or a precursor of this protein, which comprises the following amino acid sequence (a1): ##STR1## in which Xaa...
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5650554 |
Oil-body proteins as carriers of high-value peptides in plants
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
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5648072 |
Methods of inducing gamma interferon and stimulating blood cell populations using natural killer stimulatory factor
Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
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5648467 |
Natural killer cell stimulatory factor
A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a...
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5646010 |
Methods and compositions for expression of competent eukaryotic gene products
Heat-shock gene control elements from different eukaryotic cells are utilized to provide expression of competent gene products in the same or similar eukaryotic as well as in procaryotic host...
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