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6284237 |
Methods of treatment using IL-6
IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other...
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6280975 |
IL-6 mutein and DNA encoding thereto
The present invention relates to a new IL-6 mutein, a DNA sequence coding for it, its use in therapy as well as a pharmaceutical composition comprising it. It is a potent IL-6 antagonist and can be...
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6277598 |
DNA molecule encoding interferon-gamma (IFN-λ) inducing factor (IGIF, IL-18) and DNA fragment thereof
A protein which induces the IFN-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on...
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6274708 |
Mouse interleukin-11 receptor
The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject...
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6274341 |
Cytostatic process increases the productivity of cultured cells
Provided by the invention are novel methods, vectors and cells for the recombinant production of desired gene products. In particular, the invention relates to increased production of desired gene...
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6268180 |
Recombinant human recombinant human interleukin-1α
The invention relates to the cloning of the human interleukin-1α gene, its engineering into suitable expression vectors, hosts transformed with such expression vectors, and production of...
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6238889 |
Molecular cloning and expression of the Pro8 isoform of human IL-3
The invention relates to nucleotide sequences encoding human interleukin-3 (hIL-3) as well as recombinant DNAs, expression cassettes, transformed host cells, and recombinant expression methods...
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6222027 |
Molecules expressed in hippocampus
The invention provides novel developmentally-regulated hippocampal genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The...
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6217857 |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines...
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6214584 |
Human Interferon-γinducing factor
A polypeptide which has a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The polypeptide strongly induces the IFN-γ production by immunocompetent...
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6207144 |
Polypeptides with interleukin-16 activity, process for the preparation and use thereof
A nucleic acid which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein in the region coding for the said polypeptide the said...
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6200805 |
Materials and methods for screening human interleukin-4 antagonists/agonists
Stably-transformed human cell lines containing a reporter gene operatively linked to an IL-4-responsive element are provided. In some embodiments a human Fc ε RII IL-4-responsive element is used....
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6159463 |
Lymphocyte chemoattractant factor
Purified DNA encoding LCF and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an LCF-CD4 interaction and screening...
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6156301 |
Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant...
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6153409 |
Process for continuous optimized protein production in insect larvae
The present invention provides for a recombinant insect larvae and a process of manufacturing proteins utilizing insect larvae that allows for the selection of individual larvae for harvest at the...
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6132991 |
Human interleukin-3 (IL-3) variant fusion proteins
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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6074639 |
Ex vivo expansion of hematopoietic cells using interleukin-3 (IL-3) variant fusion proteins
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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6066317 |
Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
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6063600 |
DNA encoding canine interleukin-1 receptor antagonist
Canine IL-1 receptor antagonist protein, DNAs, and expression vectors carrying DNA sequence encoding canine IL-1 receptor antagonist are disclosed.
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6060284 |
DNA encoding interleukin-B30
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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6060283 |
Genomic DNA encoding human interleukin-18 (IL-18, interferon-γ inducing factor)
Disclosed is a genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ by immunocompetent cells. The genomic DNA efficiently expresses the polypeptide with high...
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6057133 |
Multivariant human IL-3 fusion proteins and their recombinant production
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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6051217 |
Therapeutic uses of interleukin-3 (IL-3) multiple mutation polypeptides
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid...
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6046035 |
Polynucleotides encoding a cardiotrophin-like cytokine
The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC...
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6037149 |
DNA encoding human asthma associated factor 1
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1....
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6030812 |
Fusion proteins comprising multiply mutated interleukin-3 (IL-3) polypeptides and second growth factors
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins,...
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5997857 |
Co-administration of interleukin-3 mutants with colony stimulating factors
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with other colony stimulating factors (CSF), cytokines, lymphokines,...
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5994104 |
Interleukin-12 fusion protein
This invention relates to Interleukin-12 fusion proteins and nucleic acid constructs encoding them, and to the use of such fusion proteins and constructs in tumour therapy, especially therapy of...
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5989867 |
DNA encoding IL-10-like homologue; related reagents
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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5985614 |
Polynucleotides encoding interleukin-19
The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are...
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5972902 |
DNA encoding human IL-6 receptor antagonist and protein encoded thereby
The present invention relates to human interleukin-6 receptor antagonists which are incapable of binding to the receptor chain responsible for transduction of the signal associated with...
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5968735 |
Vector for the expression of therapy-relevant genes
A vector for expression of relevant therapeutic genes in mammalian cells which utilizes the mdr promoter, and optionally, the mdr enhancer, operably linked to the therapeutic gene.
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5965404 |
Method for introducing nucleic acids into higher eukaryotic cells
Process and medium for the transfection of higher eukaryotic cells with DNA/polycation complexes, wherein a medium is used which contains ethyleneglycol and/or glycerol. The medium may also contain...
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5962268 |
DNA encoding an immune cell cytokine
Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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5958400 |
Interleukin-6 splice variant
Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical...
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5955315 |
Nucleic acids encoding human interleukin-4
Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the...
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5951973 |
Use of interleukin-4 (IL-4) to treat rheumatoid arthritis
A method of treating rheumatoid arthritis comprising administering human Interleukin-4 (IL-4) to an individual afflicted with the disease. The IL-4 is administered with a pharmaceutically...
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5945310 |
DNA encoding members of the IL-1 family, IL-1 delta
IL-1 delta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1 delta peptides are...
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5939288 |
Plant secretory signal peptides and nectarins
Provided herein are signal peptides, and constructs and vectors having signal peptides, as well as methods of using signal peptides to deliver proteins into secretory material. The invention...
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5935569 |
Genetic anticancer vaccine
Genetic anticancer vaccine for stimulation of patient's immune system to eradicate cancer, particularly malignant melanoma. The objective of the invention is genetic modification of allogeneic...
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5935789 |
Autonomously replicating sequences, GAPDH gene and promoter derived from Hansenula polymorpha, expression vectors containing same and method for the selection of transformants
Autonomously replicating sequences(ARS), glyceraldehyde-3-phosphate dehydrogenase(GAPDH) gene and GAPDH promoter derived from Hansenula polymorpha DL-1(ATCC 26012); a vector for H. polymorpha which...
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5936066 |
Recombinant human interleukin-1α
The invention relates to the cloning of the human IL-1 gene, its engineering into suitable expression vectors, transformation of host organisms with such expression vectors and production of...
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5928917 |
Conjugate of non-protein chemical moiety and polypeptide having cellulose binding region
Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a β-1,4-glycan matrix such as...
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5922573 |
IL-1 receptor antagonists with enhanced inhibitory activity
DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells...
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5914106 |
Interleukin-6 receptor agonists
It is known that the ligands of the group of cytokines similar to Interleuk 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and...
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5914253 |
Recombinant production of murine interferon--γ (IFN-γ) inducing factor (IGIF, IL-18)
DNA encoding a murine protein capable of inducing the production of interferon-γ by immunocompetent cells is described. The native protein from mouse liver has a molecular weight of 19±5 kDa, a...
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5897990 |
Assays for measuring immunosuppressants by reporter gene expression
Quantitative reporter gene assays allowing for highly precise measurements of immunosuppressants in bodily fluids are provided, e.g., an IL-2 reporter gene assay for measuring blood levels of...
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5891680 |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
Fusion proteins, such as a bio active IL-12 polypeptide, which comprise at least two polypeptide monomers (chains of amino acids) joined through a heterologous polypeptide linker and which are...
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5891998 |
Interleukin-6 receptor agonists
Disclosed are interleukin-6 receptor agonists. These receptor agonists were enerated by mutating amino acid positions 175, 176, 177, 181, and/or 183 of human interleukin-6.
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5889190 |
Recombinant plant viral nucleic acids
The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic...
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